Immunomodulation by Propionibacteria

Roszkowski, W.; Roszkowski, K.; Ko, H.L.; Beuth, J.; Jeljaszewicz, J.

doi:10.1016/s0934-8840(11)80686-9

Cited by 36 publications

(18 citation statements)

References 35 publications

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“…It is well-documented that cutaneous propionibacteria are potent immunomodulators, since they have been tested in several assays both in humans and rodents used as animal models [162]. Administration of cutaneous propionibacteria (P.…”

Section: Probiotic Properties For Human Applicationmentioning

confidence: 99%

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Zárate¹

2012

Probiotic in Animals

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Section: Probiotic Properties For Human Applicationmentioning

confidence: 99%

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Zárate¹

2012

Probiotic in Animals

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“…Extensive research exists on the modulation of the immune system by bacteria or their products and has shown that P. acnes is one of the most potent adjuvants (Roszkowski et al. 1990).…”

Section: Virulence and Immunological Propertiesmentioning

confidence: 99%

“…Extensive research exists on the modulation of the immune system by bacteria or their products and has shown that P. acnes is one of the most potent adjuvants (Roszkowski et al 1990). Pretreatment with heat-killed cells of P. acnes has been shown to provide protection against infection and anti-tumour activity in a variety of animal models (Eady and Ingham 1994).…”

Section: Virulence and Immunological Propertiesmentioning

confidence: 99%

Propionibacterium acnes

and

Lambert

2006

Lett Appl Microbiol

143

102

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Propionibacterium acnes, a common skin organism, is most notably recognized for its role in acne vulgaris. It also causes postoperative and device‐related infections and has been associated with a number of other conditions such as sarcoidosis and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO), although its precise role as a causative agent remains to be determined. Propionibacterium acnes produces a number of virulence factors and is well known for its inflammatory and immunomodulatory properties. Recent publication of the P. acnes genome should provide further insights into the pathogenic capabilities of the organism and potentially lead to the development of new therapies.

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“…Apart from its involvement in the pathogenesis of acne vulgaris [3] P. acnes is associated with synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) [9], and infections of the central nervous system, endocardium, joints, eyes, bone marrow and articular discs after surgical procedures [10]. Roszkowski et al studied the modulation of the immune system by propionibacteria and showed that P. acnes is one of the most potent adjuvants [11]. It was shown that pretreatment with heat-killed cells of P. acnes provides protection against infection and anti-tumor activity in animal models [12].…”

Section: Discussionmentioning

confidence: 99%

The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells.

Michalak-Stoma

Tabarkiewicz²,

Olender³

et al. 2009

Folia Histochem Cytobiol.

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Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. It has a proinflammatory activity and takes part in immune reactions modulating the Th1/Th2 cellular response. The exposure of dendritic cells (DCs) to whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation from immature DCs into antigen-presenting mature DCs. The aim of the study was to evaluate the capability of P. acnes to induce the maturation of DCs. We stimulated monocyte derived dendritic cells (Mo-DCs) from acne patients with various concetrations of heat-killed P. acnes (10 6 -10 8 bacteria/ml) cultured from acne lesions. The results showed an increase in CD80+/CD86+/DR+ and CD83+/CD1a+/DR+ cells percentage depending on the concetration of P. acnes. The expression of CD83 and CD80 (shown as the mean fluorescence intensity -MFI) increased with higher concetrations of P. acnes. There were also significant correlations between MFI of CD83, CD80, CD86 and concetration of P. acnes. The study showed that P. acnes in the concetration of 10 8 bacteria/ml is most effective in the induction of Mo-DCs maturation. Futher studies concerning the influence on the function of T cells are needed. Short communicationto whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation of immature DCs into antigen-presenting mature DCs. DCs maturation is a process where major histocompatibility complex (MHC) class I or II and costimulatory molecules (e.g. CD80 and CD86) are upregulated and at the same time specific markers like CD83 and p55 are expressed [5].The aim of the study was to evaluate the capability of P. acnes to induce the maturation of autologous DCs. Patients and methods

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Immunomodulation by Propionibacteria

Cited by 36 publications

References 35 publications

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Propionibacterium acnes

The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells.

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