2021
DOI: 10.7150/thno.46119
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Immunomodulation by systemic administration of human-induced pluripotent stem cell-derived mesenchymal stromal cells to enhance the therapeutic efficacy of cell-based therapy for treatment of myocardial infarction

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Cited by 41 publications
(31 citation statements)
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“…Therefore, inhibiting the early inflammatory response of tendon injury is beneficial to early healing. Recent studies reported that MSCs can elicit immunoregulatory responses by modulating the pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophage polarization, inducing regulatory T cells, and producing anti-inflammatory cytokines [ 38 , 39 ]. Considering exosomes are the main substances used by MSCs to exert their effectiveness, we hypothesized that exosomes would recapitulate the immunomodulatory effects of their parent cells.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, inhibiting the early inflammatory response of tendon injury is beneficial to early healing. Recent studies reported that MSCs can elicit immunoregulatory responses by modulating the pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophage polarization, inducing regulatory T cells, and producing anti-inflammatory cytokines [ 38 , 39 ]. Considering exosomes are the main substances used by MSCs to exert their effectiveness, we hypothesized that exosomes would recapitulate the immunomodulatory effects of their parent cells.…”
Section: Discussionmentioning
confidence: 99%
“…There is evidence that intravenous, intracoronary, or intramyocardial administration of MSCs can improve LV function in an MI model ( Bagno et al., 2018 ; Hu et al., 2016 ; Liao et al., 2019 ). Moreover, our previous study showed that pre-transplantation systemic intravenous administration of MSCs improved retention and therapeutic efficacy of intramyocardially transplanted exogenous cells ( Sun et al., 2021 ).…”
Section: Main Textmentioning
confidence: 99%
“…Recently, our group has investigated the immunomodulatory effect of human iPSC (hiPSC)-MSCs on improving the survival and therapeutic efficacy of cells following intramyocardial transplantation into a mouse model of MI ( Sun et al., 2021 ). Our results showed that pre-transplantation systemic administration of hiPSC-MSCs increased systemic regulatory T cell (Treg) activation, decreased the number of splenic natural killer (NK) cells and inflammation, enhanced survival of transplanted hiPSC-MSCs and hiPSC-cardiomyocytes following intramyocardial transplantation, and improved the therapeutic efficacy at 4 weeks post MI.…”
Section: Main Textmentioning
confidence: 99%
“…Human iMSCs were differentiated from human induced pluripotent stem cell (hiPSC) line IMR90-iPSCs (WiCell Research Institute, Madison, WI, USA) as previously described [6,18]. Briefly, hiPSCs were cultured in MSC differentiation medium which consists of 10% fetal bovine serum (FBS), 5 ng/mL basic fibroblast growth factor (bFGF; AF-100-18B, Peprotech), 5 ng/mL epidermal growth factor (EGF; AF-100-15, Peprotech) and 55 uM 2-mercaptoethanol (Gibco, 21985023).…”
Section: Preparation and Characterization Of Imscs And Umscsmentioning
confidence: 99%