2016
DOI: 10.3390/ijms17071158
|View full text |Cite
|
Sign up to set email alerts
|

Immunomodulation Induced by Stem Cell Mobilization and Harvesting in Healthy Donors: Increased Systemic Osteopontin Levels after Treatment with Granulocyte Colony-Stimulating Factor

Abstract: Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe graft versus host disease is similar for patients receiving peripheral blood and bone marrow allografts, even though the blood grafts contain more T cells, indicating mobilization-related immunoregulatory effects. The regulatory phosphoprotein osteopontin was quantified in plasma samples from… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 65 publications
0
2
0
Order By: Relevance
“…These patients had decreased serum NT‐proBNP levels and increased left ventricular ejection fraction (LVEF) 6 months after autologous CD34+ cells infusion 5 . One possible linkage of G‐CSF mobilization and serum NT‐proBNT might lie in the phosphoprotein osteopontin (OPN), which is increased in healthy G‐CSF mobilized donors' plasma 24 . Kwee et al 25 identified several miRNAs that link OPN and NT‐proBNT, two prognostic biomarkers in patients with non‐ST elevated acute coronary syndrome (NSTE‐ACS).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These patients had decreased serum NT‐proBNP levels and increased left ventricular ejection fraction (LVEF) 6 months after autologous CD34+ cells infusion 5 . One possible linkage of G‐CSF mobilization and serum NT‐proBNT might lie in the phosphoprotein osteopontin (OPN), which is increased in healthy G‐CSF mobilized donors' plasma 24 . Kwee et al 25 identified several miRNAs that link OPN and NT‐proBNT, two prognostic biomarkers in patients with non‐ST elevated acute coronary syndrome (NSTE‐ACS).…”
Section: Discussionmentioning
confidence: 99%
“…5 One possible linkage of G-CSF mobilization and serum NT-proBNT might lie in the phosphoprotein osteopontin (OPN), which is increased in healthy G-CSF mobilized donors' plasma. 24 Kwee et al 25 identified several miRNAs that link OPN and NT-proBNT, two prognostic biomarkers in patients with non-ST elevated acute coronary syndrome (NSTE-ACS). Although none of our donors demonstrated any cardiac signs and symptoms, the molecular pathways linking both biomarkers via miRNAs certainly point to possible interactions.…”
Section: Discussionmentioning
confidence: 99%