Immunomodulators for conjunctivitis

Pacharn, Punchama; Vichyanond, Pakit

doi:10.1097/aci.0b013e328364d86a

Cited by 28 publications

(20 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both are wellknown sources of cytokine production and resident immune cells. 98,[127][128][129] As described in Section III, numerous proteases, immunoglobulins, and cytokines have been found in tear fluid of patients with KC, which could reflect changes in lacrimal gland and conjunctiva. The conjunctiva can suffer from severe immune dysregulation with detrimental effects on the ocular surface, as has been shown in diseases such as allergic conjunctivitis.…”

Section: Discussionmentioning

confidence: 98%

Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review

et al. 2015

View full text Add to dashboard Cite

“…Its certified role as a drug which prevents the release of mediators that would normally attract inflammatory cells, recommends it as therapy for asthma , allergic conjunctivitis (Pacharn and Vichyanond 2013), mastocytosis (Horan et al 1990), dermographic uritcaria (Zuberbier et al 2001) or ulcerative colitis (Raithel et al 2007). Several recent papers described other less known functions of disodium cromolyn, not related to its main function.…”

Section: Discussionmentioning

confidence: 99%

The Hidden Side of Disodium Cromolyn: from Mast Cell Stabilizer to an Angiogenic Factor and Antitumor Agent

Cimpean

Raica

2016

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

Scattered data suggested that disodium cromolyn, well known as a mast cell stabilizer shows some effects on tumor cells and tumor-associated newly formed vascular networks. Most of these studies used tumor cell lines assessed by in vitro studies. Nor disodium cromolyn effects on melanoma cell lines were studied yet, neither its influence on recruited tumor blood vessels or angiogenic growth factors expression. We designed here a study regarding disodium cromolyn effects on A375 melanoma tumor cells implanted on chick embryo chorioallantoic membrane (CAM) and on blood vessels recruited by the experimental melanoma in the absence of mast cells, knowing that within CAM, the existence of mast cells are not certified yet. We also assessed the role of disodium cromolyn on the expression of several angiogenic growth factors. Disodium cromoglycate differentially acts on tumor cells and blood vessels. Extensive necrotic areas of experimental melanoma together with an increased number of peritumor blood vessels were observed in treated specimens as compared with untreated tumors. Disodium cromolyn inhibited VEGF and PDGF-BB expression, and had no effects on EG VEGF expression between treated and non treated specimens in a mast cells free microenvironment. Our results sustain the direct antitumor effects of sodium cromolyn and suggest the involvement of several growth factors in the recruitment of tumor vessels by A375 melanoma tumor cells. The expression of growth factors is differentially influenced by sodium cromolyn treatment.

show abstract

“…A combination of these agents is often needed to relieve symptoms, and a trial of different agents may be warranted. For severe or unresponsive cases, topical corticosteroids, immunotherapy, and immunomodulators (cyclosporine A and tacrolimus) may be considered [77]. Vasoconstrictors and antihistamine-decongestants are discouraged as overuse causes rebound hyperemia [78].…”

Section: Atopic Keratoconjunctivitismentioning

confidence: 99%

An Update on Neonatal and Pediatric Conjunctivitis

Andalibi

Haidara

Bor

et al. 2015

Curr Ophthalmol Rep

View full text Add to dashboard Cite

Conjunctivitis is among the most common ophthalmic conditions found in neonatal and pediatric patients. It has a wide range of clinical presentations and outcomes, ranging from self-limiting hyperemia to blindness and life-threatening systemic illness. This review explores the epidemiology, etiology, and diagnosis of conjunctivitis in the neonatal and pediatric population. In addition, it explores recent trends in transmission across different populations and evidence-based approaches that clinicians may use in treating neonatal and pediatric conjunctivitis.

show abstract

Immunomodulators for conjunctivitis

Abstract: Several immunomodulatory options are currently available for treatment of allergic conjunctivitis. These therapeutic availabilities bring about a better therapeutic outcome for patients with allergic conjunctivitis, particularly those on the severe end of the spectrum.

Cited by 28 publications

References 85 publications

Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review

Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review

The Hidden Side of Disodium Cromolyn: from Mast Cell Stabilizer to an Angiogenic Factor and Antitumor Agent

An Update on Neonatal and Pediatric Conjunctivitis

Contact Info

Product

Resources

About