Immunomodulators use in a treatment of lower urogenital tract infections in women

Abstract

Relevance. Women’ immune system indexes are dependent on cyclic hormonal influences. They decrease in the ovulation and in luteal phase of the menstrual cycle forming a “window of vulnerability” when there is an increased risk of infection with pathogenic and opportunistic microorganisms. Infected tissues inflammatory reaction in its turn aggravates these disorders. For these reasons, one should not only use empirical regimens of antimicrobial therapy covering wide spectrum of pathogens, but also to consider the possibility and need of a comprehensive approach with use of adjuvant treatment methods (detoxification, immunomodulatory, supportive therapy). Aim. To determine immunological changes in the body of women with lower genital tract infectious and inflammatory diseases and to justify a role of immunomodulators in increasing of treatment and relapse prevention efficacy. Materials and methods. In order to write this review domestic and foreign publications were searched in Russian and international search systems (PubMed, eLIBRARY, etc.) for the last 2-22 years. The review included articles from peer-reviewed literature. Results. Due to its immunomodulatory, anti-inflammatory and detoxifying effects azoximer bromide contributes to an increase in treatment efficacy: elimination of pathogenic flora increases by 30%, clinical manifestations resolution occurs 2 times faster, a relapse risk reduces. Conclusion. To activate anti-infective immunity a comprehensive treatment with immunomodulators use is advisable.