Immunomodulatory activity of methanol leaf extracts of Cameroonian medicinal plants

Djafoua, Yves Marcel; Mouokeu, Raymond Simplice; Tume, Christopher; Kamtchueng, Monique Odette; Kuiaté, Jules-Roger

doi:10.1515/jcim-2014-0023

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…Many attempts are being made to find safe immunoenhancing agents that reduce myelosuppression and enhance the immune response. For example, some plant extracts are known for their specific biological properties, which when administered to Cyimmunosuppressed animals are able to increase the immune response (22)(23)(24). Polysaccharides of different origins have also been described as protectors against myelosuppression and immunosuppression caused by Cy (25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

et al. 2021

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Myelosuppression is the major dose-limiting toxicity of cancer chemotherapy. There have been many attempts to find new strategies that reduce myelosuppression. The dietary supplementation with lactic acid bacteria (LAB) improved respiratory innate immune response and the resistance against respiratory pathogens in immunosupressed hosts. Although LAB viability is an important factor in achieving optimal protective effects, non-viable LAB are capable of stimulating immunity. In this work, we studied the ability of oral preventive administration of viable and non-viable Lactobacillus rhamnosus CRL1505 or L. plantarum CRL1506 (Lr05, Lr05NV, Lp06V or Lp06NV, respectively) to minimize myelosuppressive and immunosuppressive effects derived from chemotherapy. Cyclophosphamide (Cy) impaired steady-state myelopoiesis in lactobacilli-treated and untreated control mice. Lr05V, Lr05NV and Lp06V treatments were the most effective to induce the early recovery of bone marrow (BM) tissue architecture, leukocytes, myeloid, pool mitotic and post-mitotic, peroxidase positive, and Gr-1Low/High cells in BM. We selected the CRL1505 strain for being the one capable of maintaining its myelopoiesis-enhancing properties in its non-viable form. Although the CRL1505 treatments do not modify the Cy ability to induce apoptosis, both increased the incorporation of BrdU in BM cells. Consequently, Lr05NV and Lr05V treatments were able to promote early recovery of LSK cells (Lin-Sca-1+c-Kit+ cells), multipotent progenitors (Lin-Sca-1+c-Kit+CD34+ cells), and myeloid cells (Gr-1+Ly6G+Ly6C- cells) with respect to the untreated Cy control. In addition, these treatments were able to increase the frequency of IL17A-producing innate lymphoid cells in the intestinal lamina propria (IL-17A+RORγt+CD4-NKp46+ cells) after Cy injection. These results were correlated with an increase in the IL-17A serum levels, a GM-CSF high expression and a CXCL12 lower expression in BM. Therefore, both Lr05V and Lr05NV treatments are able to activate beneficially the IL-17A/GM-CSF axis and accelerate the recovery of Cy-induced immunosuppression by increasing BM myeloid precursors. We demonstrated for the first time the beneficial effect of CRL1505 strain on myelopoiesis affected by a chemotherapeutic drug. Furthermore, Lr05NV could be a good and safe resource for reducing chemotherapy-induced leukopenia. The results are a starting point for future research and open up broad prospects for future applications of the immunobiotics.

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Section: Discussionmentioning

confidence: 99%

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

et al. 2021

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“…The Methanolic leaf extract of Moringa oleifera shows an immunostimulatory effect on both the cell-mediated and humoral immune systems in the Wistar albino rats 6 . The methanolic leaf extracts of Cameroonian medicinal plants possess immunomodulatory activity 7 .The ethanolic extract of Sonerila tinnevelliensis showed a stimulatory effect on both humoral and cellular immune functions in animal models 8 . Caesalpinia sappan shows the nonspecific immunomodulatory effect on murine peritoneal macrophages 9 .…”

Section: Ijpsr (2018) Volume 9 Issue 4 (Research Article)mentioning

confidence: 99%

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2018

IJPSR

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Objective: To determine the immunomodulatory activity of leaves of Rumex vesicarius Linn. and Symplocos racemosa Roxb. Methods: The ethyl acetate and ethanolic extract of Rumex Vesicarius Linn. and ethanolic and N-hexane extract of Symplocos racemosa Roxb. were administered orally at the dosage level of 200 mg/kg/day and 400 mg/kg/day each according to the body weight of Rat. The assessments of immunomodulatory activity were carried out by using Carbon Clearance Test and Delayed Type Hypersensitivity Test. Result: Oral administration of all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. significantly (P < 0.0001) showed an increase in phagocytic activity and DTH response in Rat at an experimental dose. The study also comprises the acute toxicity study and preliminary phytochemical screening. Conclusion:The study demonstrate that all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. shows the significant immunomodulatory effect on both humoral as well as cell-mediated immunity.

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“…Terminalia chebulaand Adenocarpus mannii are known for their immunomodulation properties [16,17], Thea assamica in the treatment of impetigo [18], Ocimum gratissimum in the treatment of acne [19], Drechslera rostata and Polygala molluginifolia for their antitumor activities [20,21]. Medicinal plants including Ageratum conyzoides, Celosia trigyna, Centella asiatica, Brassica nigra, Racunculus oreophytus, Azadiracha indica, Ficus exasperate, Senna hirsuta, Morus alba, Artocarpus heterophyllus have all been reported for their ethnomedicinal use in various ethnic groups [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Plant active products and emerging interventions in water potabilisation: disinfection and multi-drug resistant pathogen treatment

et al. 2021

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Background This review aims at establishing the emerging applications of phytobiotics in water treatment and disinfection. Results Statistical analysis of data obtained revealed that the use of plant product in water treatment needs more research attention. A major observation is that plants possess multifaceted components and can be sustainably developed into products for water treatment. The seed (24.53%), flower (20.75), leaf (16.98%) and fruit (11.32%) biomasses are preferred against bulb (3.77%), resin (1.89%), bark (1.89%) and tuber (1.89%). The observation suggests that novel applications of plant in water treatment need further exploration since vast and broader antimicrobial activities (63.63%) is reported than water treatment application (36.37%). Conclusions This review has revealed the existing knowledge gaps in exploration of plant resources for water treatment and product development. Chemical complexity of some plant extracts, lack of standardisation, slow working rate, poor water solubility, extraction and purification complexities are limitations that need to be overcome for industrial adoption of phytochemicals in water treatment. The field of phytobiotics should engage modern methodologies such as proteomics, genomics, and metabolomics to minimise challenges confronting phytobiotic standardisation. The knowledge disseminated awaits novel application for plant product development in water treatment.

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Immunomodulatory activity of methanol leaf extracts of Cameroonian medicinal plants

Abstract: These results suggest that the A. mannii, C. melanantha, O. gratissimum, A. intrusa and C. chinensis methanol extracts possess immunomodulatory activity. This constitutes additional data on the well-known biological properties of these plants.

Cited by 9 publications

References 30 publications

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

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Plant active products and emerging interventions in water potabilisation: disinfection and multi-drug resistant pathogen treatment

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