Immunomodulatory effects of herbal formula of astragalus polysaccharide (APS) and polysaccharopeptide (PSP) in mice with lung cancer

Zhou, Xing; Liu, Zijing; Long, Tingting; Zhou, Lijng; Bao, Yixi

doi:10.1016/j.ijbiomac.2017.08.054

Cited by 50 publications

(35 citation statements)

References 27 publications

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“…Its China Food and Drug Administration number is Z20026868. Active compounds of KAI include astragalus polysaccharides, astragalosides, ginsenosides, ginseng polysaccharide and oxymatfine [12], and various studies have shown that KAI possesses multiply pharmacological effects: (1)inducing tumor cell apoptosis [13,14]; (2)inhibiting tumor cell proliferation, invasion and metastasis [15,16]; (3)increasing the sensitivity of chemotherapy drugs and reducing adverse events caused by chemotherapy [17][18][19]; (4)improving the body's immune function [20][21][22]. In the clinic, Fan et al found that KAI has obtained good curative effect, could ultimately prolong the survival and improve the quality of life, and mainly used in the treatment of multi-cancers, including liver, lung, colorectal cancer, etc.…”

Section: Introductionmentioning

confidence: 99%

“…[23]. In terms of animal experiments, Zhou et al found that herbal formula astragalus polysaccharide and polysaccharopeptide could show immunomodulatory effects and anti-tumor activity in mice with lung cancer [24]. Meanwhile, the results of Xie et al showed that Ginsenoside Rg3 could obviously inhibit the volume and weight of tumor in xenografts model, and the mechanism of Ginsenoside Rg3 anti-tumor effects may be related with inhibiting PI3K/Akt signaling pathways [25].…”

Section: Introductionmentioning

confidence: 99%

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Kangai Injection Combined with Platinum-based Chemotherapy for the Treatment of Stage III/IV Non-Small Cell Lung Cancer: A Meta-analysis and Systematic Review of 35 Randomized Controlled Trials

Li¹,

Ji²,

Zhang³

et al. 2019

J. Cancer

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Objective: In an effort to inform evidence-based guidelines for clinical practice, we performed a meta-analysis to systematically evaluate the safety and efficacy of Kangai injection (KAI) plus platinum-based chemotherapy for stage III/IV non-small cell lung cancer (NSCLC). Methods: Randomized controlled trials (RCTs) comparing KAI plus platinum-based chemotherapy (experimental group) to chemotherapy alone (control group) were electronically retrieved from the Cochrane Library, PubMed, EMbase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Biological Medicine (CBM) Database, Wanfang Database, and the VIP Database for Chinese Technical Periodicals. RCTs published from the date of inception to July 5, 2018, were included. All trials were assessed for methodological quality in accordance with the Cochrane Reviewer's Handbook for Systematic Reviews of Intervention. Meta-analysis was performed using RevMan5.3 Software and Comprehensive Meta-Analysis (CMA) 2.0. Results: The final analysis included 35 RCTs involving 2,618 patients. Our meta-analysis revealed that KAI combined with platinum-based chemotherapy was associated with significantly greater objective response rate (ORR) (RR=1.36, 95% CI: 1.25-1.49, P<0.00001) and disease control rate (DCR) (RR=1.14, 95% CI: 1.09-1.18, P<0.00001), improvements in quality of life (QOL) (RR=1.75, 95% CI: 1.59-1.93, P<0.00001), and decreases in the incidence of gastrointestinal reactions (RR=0.64, 95% CI: 0.54-0.77, P<0.00001), leukocytopenia (RR=0.54, 95% CI: 0.46-0.63, P<0.00001) and thrombocytopenia (RR=0.52, 95% CI: 0.36-0.76, P=0.0007) when compared with chemotherapy alone. In addition, combined treatment was associated with greater regulation of tumor immune function, as indicated by increases in the proportion of NK, CD3 + , and CD4 + cells (MD=2.27, 95% CI: 1.18-3.36, P<0.0001; MD=12.86, 95% CI: 11.64-14.08, P<0.00001; and MD=5.48, 95% CI: 2.68-8.28, P=0.0001) and decreases in the percentage of CD8 + cells (MD=-2.37, 95% CI from-4.51 to-0.23, P=0.03). Conclusions: From the available evidence, our results indicate that KAI plus platinum-based chemotherapy could be more effective in improving clinical efficacy, decreasing the incidence of adverse reactions and regulating the tumor immune function than chemotherapy alone in the treatment of stage

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kangai Injection Combined with Platinum-based Chemotherapy for the Treatment of Stage III/IV Non-Small Cell Lung Cancer: A Meta-analysis and Systematic Review of 35 Randomized Controlled Trials

Li¹,

Ji²,

Zhang³

et al. 2019

J. Cancer

View full text Add to dashboard Cite

show abstract

“…As shown in Figure , group P3 gave the highest hematological parameter, followed by P2 and P1, indicating a dose dependent manner. Additionally, group P3 restored WBC, RBC, and platelets to normal levels and showed no differences to group P. These results suggested that LMP could help to improve the chemotherapy‐induced immunity reduction and immunity decline (Zhou, Liu, Long, Zhou, & Bao, ).…”

Section: Resultsmentioning

confidence: 89%

Optimization of Maca polysaccharide extraction process and its chemo‐protective effects on cyclophosphamide‐induced mice

Wang

Huang

et al. 2018

J Food Process Engineering

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In this study, the extraction process of Maca polysaccharide (LMP) was deeply studied and its chemo‐protective effects on Cyclophosphamide (Cy)‐induced mice were evaluated. By single factor investigation and response surface methodology optimization, it was found that the liquid‐to‐solid ratio, extraction time, and extraction temperature were the main factors which affected the extraction yield of LMP. The optimum extraction process was obtained by Box–Behnken design combined with response surface methodology. It was found that, at the condition of liquid‐to‐solid ratio of 30:1; extraction time of 2.3 hr; and extraction temperature of 90°C, the yield of the LMP could reach 46.56%. Furthermore, by oral administration of LMP, the cyclophosphamide‐induced mice showed the proliferation of lymphocyte and the phagocytic capacity of macrophages’ enhancements. The number of white blood cell, red blood cell, and platelets in the peripheral blood were up‐regulated; the spleen total superoxide dismutase, Catalase, and Glutathione‐peroxidase activities were enhanced, while the Serum malondialdehyde and Triacylglycerols content was reduced. Therefore, our work provided an effective way for extraction of LMP and demonstrated the chemo‐protective effects of LMP on the animal level. Practical application Natural polysaccharides from functional food sources are widely accepted for their bioactive activities. As extraction conditions significantly affected the quality and yield of polysaccharides, the effective extraction process for polysaccharides should be systematically investigated. In the current work, the optimum conditions for polysaccharides extraction from Maca (Lepidium meyenii Walp.) (LMP) were obtained using liquid‐to‐solid ratio of 30:1 for 2.3 hr at 90°C. The Mass characterization and Monosaccharide Composition of LMP were also determined. Furthermore, the extracted LMP exhibited well Chemo‐protective activities on Cyclophosphamide‐induced mice. Therefore, our work showed the potential applications of Maca polysaccharides as the easily accessible source of natural immunopotentiating agents in function food and pharmaceutical industry.

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“…aPS is primarily composed of α-1,4-(1,6)-glucan, rhamnus-galacturonic acid polysaccharide i, arabic-galactopolysaccharide and arabic-galactoprotein polysaccharide (42). aPS has been demonstrated to display therapeutic effects in multiple diseases, including a variety of tumor diseases, such as hepatocellular carcinoma and lung carcinoma (28)(29)(30)(31)(32)(33)43). However, there are only a few studies that have reported the effect of aPS on breast cancer, and these studies primarily focused on the effects of aPS on the proliferation and immune regulation of breast cancer cells (30,44).…”

Section: Discussionmentioning

confidence: 99%

Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway

Yang

Sun

et al. 2020

Mol Med Report

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epithelial-mesenchymal transition (eMT) serves an important role in tumor migration and invasion. Astragalus polysaccharide (aPS), which is the main component of the traditional chinese medicine Astragalus membranaceus, has been identified to display an antitumor effect. However, the effects and mechanisms of aPS during breast cancer migration and invasion are not completely understood. The present study investigated whether aPS inhibited breast cancer migration and invasion by modulating the eMT pathway. an MTT assay and a Ki67 immunofluorescence staining assay demonstrated that aPS inhibited the proliferation of breast cancer cells. The results of the wound healing and Transwell Matrigel invasion assays suggested that aPS decreased the migration and invasion of breast cancer cells. The western blotting and immunofluorescence analyses further demonstrated that aPS had a regulatory effect on eMT-related molecules. aPS decreased the expression levels of Snail and vimentin, but increased e-cadherin expression. aPS also downregulated Wnt1, β-catenin and downstream target expression. additionally, the present results suggested that aPS decreased the proliferation, and eMT-mediated migration and invasion of cells by inhibiting the Wnt/β-catenin signaling pathway. The present study suggested that aPS may serve as a promising therapeutic agent for breast cancer.

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Immunomodulatory effects of herbal formula of astragalus polysaccharide (APS) and polysaccharopeptide (PSP) in mice with lung cancer

Cited by 50 publications

References 27 publications

Kangai Injection Combined with Platinum-based Chemotherapy for the Treatment of Stage III/IV Non-Small Cell Lung Cancer: A Meta-analysis and Systematic Review of 35 Randomized Controlled Trials

Kangai Injection Combined with Platinum-based Chemotherapy for the Treatment of Stage III/IV Non-Small Cell Lung Cancer: A Meta-analysis and Systematic Review of 35 Randomized Controlled Trials

Optimization of Maca polysaccharide extraction process and its chemo‐protective effects on cyclophosphamide‐induced mice

Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway

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