Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

Mudgal, Jayesh; Mudgal, Piya Paul; Kinra, Manas; Raval, Ritu

doi:10.1111/sji.12749

Cited by 26 publications

(14 citation statements)

References 33 publications

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“…It has been confirmed that COS administration by intraperitoneal injection and intragastric administration significantly improved the phagocytic function of mouse peritoneal macrophages, increased the index of immune organs such as thymus and spleen, stimulated lymphocytes to secrete IL-2 cytokines, and enhanced the activity of NK cells [21,22]. COS stimulated the secretion of other cytokines by activating macrophages, to then produce a cascade reaction [23].…”

Section: Introductionmentioning

confidence: 83%

The role of Chito-oligosaccharide in regulating ovarian germ stem cells function and restoring ovarian function in chemotherapy mice

Huang

Zhu

et al. 2021

Reprod Biol Endocrinol

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In recent years, the discovery of ovarian germ stem cells (OGSCs) has provided a new research direction for the treatment of female infertility. The ovarian microenvironment affects the proliferation and differentiation of OGSCs, and immune cells and related cytokines are important components of the microenvironment. However, whether improving the ovarian microenvironment can regulate the proliferation of OGSCs and remodel ovarian function has not been reported. In this study, we chelated chito-oligosaccharide (COS) with fluorescein isothiocyanate (FITC) to track the distribution of COS in the body. COS was given to mice through the best route of administration, and the changes in ovarian and immune function were detected using assays of organ index, follicle counting, serum estrogen (E2) and anti-Mullerian hormone (AMH) levels, and the expression of IL-2 and TNF-α in the ovaries. We found that COS significantly increased the organ index of the ovary and immune organs, reduced the rate of follicular atresia, increased the levels of E2 and AMH hormones, and increased the protein expression of IL-2 and TNF-α in the ovary. Then, COS and OGSCs were co-cultured to observe the combination of COS and OGSCs, and measure the survival rate of OGSCs. With increasing time, the fluorescence intensity of cells gradually increased, and the cytokines IL-2 and TNF-α significantly promoted the proliferation of OGSCs. In conclusion, COS could significantly improve the ovarian and immune function of chemotherapy model mice, and improve the survival rate of OGSCs, which provided a preliminary blueprint for further exploring the mechanism of COS in protecting ovarian function.

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Section: Introductionmentioning

confidence: 83%

The role of Chito-oligosaccharide in regulating ovarian germ stem cells function and restoring ovarian function in chemotherapy mice

Huang

Zhu

et al. 2021

Reprod Biol Endocrinol

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“…It has been reported that chitosan-based nanosystems could significantly increase the secretion of IFN-γ by Th1 cells and stimulate the cell-mediated immunity. Compared to chitosan oligosaccharides, the chitosan nanoparticles showed an enhanced immunomodulatory effect (1.2–1.5-fold), indicating the immunomodulatory effect could be tuned by aggregation of nanoparticles [ 211 ]. Wardani et al [ 212 ] also applied chitosan nanoparticles to animal models and concluded that these nanoparticles could effectively stimulate immune responses and have a therapeutic potential for immunotherapy.…”

Section: Chitosan-based Nanomedicinesmentioning

confidence: 99%

Polysaccharide-based nanomedicines for cancer immunotherapy: A review

Zeng

Xiang

Sheng

et al. 2021

Bioactive Materials

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Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target) efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects. Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as they could interact with immune system to stimulate an enhanced immune response. Their structures offer versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics.

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“…A very recent study, done on chitosan-based NPs and oligosaccharides in cyclosporin treated mice, found the NPs to be superior to chitosan itself in terms of their immunomodulatory abilities, which was attributed to the unique characteristics and biological activities of the NPs. The authors argue that physiochemical properties of NPs, per se, influence their interaction with immune cells to induce both desirable effects and unavoidable, undesirable nanotoxicity [96].…”

Section: Leukocyte Function In Hemostasis and The Mechanisms Involmentioning

confidence: 99%

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Harpe

Kondiah

Choonara

et al. 2019

Cells

249

143

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Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions including cancer and human immunodeficiency virus (HIV), yet still hold the potential to improve drug delivery to elusive target sites. Even though most nanoparticles will encounter blood at a certain stage of their transport through the body, the interactions between nanoparticles and blood cells is still poorly understood and the importance of evaluating nanoparticle hemocompatibility is vastly understated. In contrast to most review articles that look at the interference of nanoparticles with the intricate coagulation cascade, this review will explore nanoparticle hemocompatibility from a cellular angle. The most important functions of the three cellular components of blood, namely erythrocytes, platelets and leukocytes, in hemostasis are highlighted. The potential deleterious effects that nanoparticles can have on these cells are discussed and insight is provided into some of the complex mechanisms involved in nanoparticle–blood cell interactions. Throughout the review, emphasis is placed on the importance of undertaking thorough, all-inclusive hemocompatibility studies on newly engineered nanoparticles to facilitate their translation into clinical application.

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Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

Cited by 26 publications

References 33 publications

The role of Chito-oligosaccharide in regulating ovarian germ stem cells function and restoring ovarian function in chemotherapy mice

The role of Chito-oligosaccharide in regulating ovarian germ stem cells function and restoring ovarian function in chemotherapy mice

Polysaccharide-based nanomedicines for cancer immunotherapy: A review

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

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