2018
DOI: 10.1016/j.acthis.2018.03.009
|View full text |Cite
|
Sign up to set email alerts
|

Immunomorphometric variations of sustentacular cells of the male viscacha adrenal medulla during the annual reproductive cycle. Effects of androgens and melatonin

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
7
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
(7 citation statements)
references
References 59 publications
0
7
0
Order By: Relevance
“…In addition, our earlier findings indicated that PILE possesses anti-hyperglycemic activity ( 17 ). PILE mainly exerts this activity by four mechanisms: i) Acting as free radical scavengers in peroxidation and preventing the expression of oxidative stress-related proteins ( 12 , 18 , 30 ); ii) improving liver carbohydrate metabolism ( 31 ); iii) improving glucose uptake through mediators of the insulin signaling pathway ( 23 ); and iv) possessing α-glucosidase inhibitory effects, which can delay the breakdown of starch into glucose, increasing glucose uptake from the circulation, lowering blood glucose levels ( 32 ). Since a previous study reported that treatment with PILE preserved liver function by restoring AST, ALT and ALP levels in the mouse sera ( 17 ), the role of PILE treatment on hyperglycemia-induced liver damage was investigated in the present study.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, our earlier findings indicated that PILE possesses anti-hyperglycemic activity ( 17 ). PILE mainly exerts this activity by four mechanisms: i) Acting as free radical scavengers in peroxidation and preventing the expression of oxidative stress-related proteins ( 12 , 18 , 30 ); ii) improving liver carbohydrate metabolism ( 31 ); iii) improving glucose uptake through mediators of the insulin signaling pathway ( 23 ); and iv) possessing α-glucosidase inhibitory effects, which can delay the breakdown of starch into glucose, increasing glucose uptake from the circulation, lowering blood glucose levels ( 32 ). Since a previous study reported that treatment with PILE preserved liver function by restoring AST, ALT and ALP levels in the mouse sera ( 17 ), the role of PILE treatment on hyperglycemia-induced liver damage was investigated in the present study.…”
Section: Discussionmentioning
confidence: 99%
“…The threshold parameters remained consistent for all images. The % IA for each group was calculated by dividing the sum of the IA by the sum of the area of each microscopic field multiplied by 100 (23).…”
Section: Induction Of Diabetes In Experimental Animalsmentioning
confidence: 99%
“…4,24 They are supposed to represent support elements, but also participate in the modulation of the activity of the adrenal medulla, probably through paracrine effects. 9 In human medicine a higher number of sustentacular cells in malignant pheochromocytomas has been described, 23 but not in others. 4,24 There are limitations to this study to be mentioned.…”
Section: Discussionmentioning
confidence: 99%
“…After 9 weeks of melatonin administration, all animals were sacrificed and the adrenal glands were excised. This experimental design has already been used in previous experiments for this species (Gallol & Mohamed, 2018; Rosales, Busolini, Mohamed, & Filippa, 2016).…”
Section: Methodsmentioning
confidence: 99%
“…After 6 weeks, all animals were sacrificed and the adrenal glands were excised. This time length has been used in previous castration experiments conducted in this species (Filippa, Godoy, Perez, & Mohamed, 2014; Gallol & Mohamed, 2018), and it is similar to the castration time length in which major histological changes could be observed in the adrenal gland of other rodents (Benmouloud et al, 2014; Hall & Korenchevsky, 1938). Gonadal activity in the control group was assessed through histological examination of testes.…”
Section: Methodsmentioning
confidence: 99%