Immunophenotypic Evaluation of DNA Mismatch Repair Markers in 2 Cases of Synchronous Histomorphologically Distinct Gastric Adenocarcinomas With Gastrointestinal Stromal Tumors of the Proximal Small Bowel

Athanassiou, Evangelos; Vamvakopoulou, Dimitra; Zacharoulis, Dimitrios; Paroutoglou, George; Sioutopoulou, Despina; Tepetes, Konstantinos; Nomikos, Iakovos N.; Vamvakopoulos, Nicholas C.

doi:10.1097/pai.0b013e3181ca8fbd

Applied Immunohistochemistry &Amp; Molecular Morphology

2010

DOI: 10.1097/pai.0b013e3181ca8fbd

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Immunophenotypic Evaluation of DNA Mismatch Repair Markers in 2 Cases of Synchronous Histomorphologically Distinct Gastric Adenocarcinomas With Gastrointestinal Stromal Tumors of the Proximal Small Bowel

Evangelos Athanassiou¹,

Dimitra Vamvakopoulou²,

Dimitrios Zacharoulis

et al.

Abstract: Good and bad prognosis for disease-free survival of patients based on reduced and elevated combined MMR phenotypic expression of the 2 histomorphologically distinct GADCs, could be explained by disease-associated emergence of genomic MMR alterations in the tumor. The impact of synchronous GISTs with common intermediate MMR phenotypes on patient survival is rather incidental and secondary to predominating GADCs.

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2019

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Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Waidhauser¹,

Bornemann²,

Trepel

et al. 2019

WJG

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BACKGROUND In recent years, increasing evidence of second neoplasms associated with gastrointestinal stromal tumors (GIST) has been found. Numerous case reports, mostly retrospective studies and a few reviews, have been published. To our knowledge, however, no systematic review or meta-analysis of the existing data has been performed so far. AIM To prepare a compilation, as complete as possible, of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency, localization, and types of GIST-associated neoplasms. METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary, synchronous, coincident/tumor, neoplasm, and relevant publications were selected by two independent authors. RESULTS Initially, 3042 publications were found. After deletion of duplicates, 1631 remained, and 130 papers were selected; 22 of these were original studies with a minimum of 20 patients, and 108 were case reports. In the 22 selected studies, comprising a total number of 12050 patients, an overall rate of GIST-associated neoplasias of 20% could be calculated. Most second neoplasias were found in the gastrointestinal tract (32%) and in the male and female urogenital tract (30%). The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias. CONCLUSION In this first systematic review, we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias. The question whether there is an underlying causal association will need further investigation. Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging.

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Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Waidhauser¹,

Bornemann²,

Trepel

et al. 2019

WJG

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show abstract

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Immunophenotypic Evaluation of DNA Mismatch Repair Markers in 2 Cases of Synchronous Histomorphologically Distinct Gastric Adenocarcinomas With Gastrointestinal Stromal Tumors of the Proximal Small Bowel

Cited by 1 publication

References 15 publications

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

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