Immunoreactive TSH cells in the pituitary of female middle-aged rats after treatment with estradiol or calcium

Sekulić, Milka; Lovren, Mirjana; Milošević, Verica

doi:10.1016/s0065-1281(98)80026-3

Cited by 12 publications

(18 citation statements)

References 14 publications

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“…TSH cells in middle-aged female rats from our experiments were mainly localised in the ventral or middle portion of the anterior pituitary gland (10). These cells adopted a variety of shapes (round, polyhedral or irregular) and had an intensely immunostained cytoplasm (Figure 1 e).…”

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 75%

“…In middle-aged female rats treated with EDP, the immunopositive TSH cells were pycnotic and darkly stained (Figure 1 f) (10). In the animal model of menopause we used, the volume and volume density of the TSH cells significantly decreased after treatment with EDP by 44% and 67%, respectively, in comparison with the control females (10).…”

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 92%

“…These cells adopted a variety of shapes (round, polyhedral or irregular) and had an intensely immunostained cytoplasm (Figure 1 e). Their volume density amounted to approximately 15% (10). Specifically, the number of TSH cells in middle-aged female rats per unit area (mm 2 ) was 110 (10), and their volume decreased with age (26).…”

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 98%

“…Simultaneously, alterations in some other hormone-producing cell populations were also found in ageing female rats and women (5,(9)(10)(11). Despite some risks (12), estradiol replacement represents the classical therapeutic approach in the prevention of health problems due to ovarian hormone deficiency (13,14).…”

Section: Starenje Kod žEnskog Pola Je Biološki Proces Tokom Kojeg Dolmentioning

confidence: 99%

“…Various animal models have been developed to define the space for problematising the multiple morphofunctional changes during menopause, as well as to solve the present controversies regarding the application of estradiol in humans. Our experimental work in the field implied the usage of intact middle-aged (14 months old) or ovariectomised adult (3 months old) Wistar female rats, for which the pituitary histological and hormone secreting studies had a central role (10,11,(15)(16)(17)(18). Herein, we aim to present the accumulated data regarding the various populations of anterior pituitary hormone-producing cells in our animal models of menopause and in related studies, as well as to elaborate the observed effects of synthetic estradiol application in these experimental studies.…”

Section: Starenje Kod žEnskog Pola Je Biološki Proces Tokom Kojeg Dolmentioning

confidence: 99%

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Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Milošević

Ajdžanović

2014

Serbian Journal of Experimental and Clinical Research

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Female ageing represents the biological process of structural and functional changes in endocrine cells and tissues, as well as in pituitary hormone-producing cells. In addition to the hypothalamic releasing hormones, estradiol plays a signifi cant role in the regulation SAŽETAK Starenje kod ženskog pola je biološki proces tokom kojeg dolazi do promena u strukturi i funkciji endokrinih ćelija i tkiva, a posebnu osetljivost ispoljavaju hipofi zne hormonprodukujuće ć elije. Pored oslobađajućih hormona hipotalamusa i estradiol ostvaruje zapaženu ulogu u regulaciji sinteze i sekrecije hipofi znih hormona, a još uvek se koristi u terapiji menopauzalnih tegoba. Efekti starenja ili ovarijektomije, kao i primene sintetskog estradiola pod tim okolnostima su ispitivani na hormon-produkujućim ć elijama hipofi ze ženki pacova srednjeg doba (animalni modeli menopauze) i to: gonadotropima (FSH i LH), tirotropima (TSH), somatotropima (GH), mamotropima (PRL) i kortikotropima (ACTH

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Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 75%

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 92%

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 98%

Section: Starenje Kod žEnskog Pola Je Biološki Proces Tokom Kojeg Dolmentioning

confidence: 99%

Section: Starenje Kod žEnskog Pola Je Biološki Proces Tokom Kojeg Dolmentioning

confidence: 99%

See 3 more Smart Citations

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Milošević

Ajdžanović

2014

Serbian Journal of Experimental and Clinical Research

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Immunohistochemical and Morphometric Study of Pituitary Pars Distalis Thyrotrophs of Male Viscacha (Lagostomus maximus maximus): Seasonal Variations and Effect of Melatonin and Castration

Filippa¹,

Mohamed²

2008

The Anatomical Record

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The physiology and behavior of viscacha vary along the year according to the modifications of environmental signals such as the photoperiod length, temperature, rainfall pattern, food composition, and social interactions. The pituitary pars distalis thyrotrophs (TSH cells) of male viscacha were immunohistochemically identified, and the morphometric parameters: percentage of immunopositive area (% IA), cell percentage in pars distalis (% PDC), number of cells per reference area (no. cells/RA), and major cellular and nuclear diameters were analyzed. Three different groups of adult male viscachas were used: (1) captured in their natural habitat during the year, (2) melatonin-administered, and (3) castrated. The thyrotrophs were localized in the ventromedial sector, mainly in the pars distalis cephalic extreme. They were oval or pyramidal in shape, and their immunostaining intensity was heterogeneous. The % IA, % PDC, and no. cells/RA exhibited a significant decrease in June-July (winter, gonadal regression period) in relation to February-March (summer-early autumn, reproductive period), and they were recovered in August-September (later winter-early spring, gonadal recovery period). No morphometric variations of TSH cells were observed in melatonin-treated animals, whereas a decrease of the % IA, % PDC, and no. cells/RA was observed in castrated animals in relation to the intact animals. Our results show TSH cell morphometric variations during the year in agreement with the animal's different physiological conditions during the reproductive cycle, and probably in response to the environmental signals changes. Melatonin does not have a direct effect on the TSH cells. However, castration modifies some thyrotroph morphometric parameters, reinforcing the hypothesis that androgens affect the cells activity.

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Immunoreactive TSH cells in juvenile and peripubertal rats after estradiol and human chorionic gonadotropin treatment

Sekulić¹,

Šošić‐Jurjević²,

Filipović³

et al. 2006

Acta Histochemica

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Immunoreactive TSH cells in the pituitary of female middle-aged rats after treatment with estradiol or calcium

Cited by 12 publications

References 14 publications

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Immunohistochemical and Morphometric Study of Pituitary Pars Distalis Thyrotrophs of Male Viscacha (Lagostomus maximus maximus): Seasonal Variations and Effect of Melatonin and Castration

Immunoreactive TSH cells in juvenile and peripubertal rats after estradiol and human chorionic gonadotropin treatment

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