Immunosenescence: Implications for response to infection and vaccination in older people

Pera, Alejandra; Campos, Carmen; López, Nelson; Hassouneh, Fakhri; Alonso, Corona; Tarazona, Raquel; Solana, Rafael

doi:10.1016/j.maturitas.2015.05.004

Cited by 319 publications

(244 citation statements)

References 63 publications

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“…29 NK cells are defined by the expression of CD56 (or N-CAM) and CD16, receptor for the Fc region of IgG (Fc-R-III). 62 The major compartment of peripheral blood NK cells is CD56dimCD16C (90%) while CD56brightCD16¡NK cells represent less than 10% of peripheral blood NK cells. Both these subsets have a high immunoregulatory capability due to cytokine and chemokine production in response to stimulation.…”

Section: B-cells Responsementioning

confidence: 99%

“…Both these subsets have a high immunoregulatory capability due to cytokine and chemokine production in response to stimulation. 62 There is a third compartment of dysfunctional NK cells, CD56¡CD16C, also found in a small percentage in peripheral blood of healthy individuals, which is expanded in HIV and in hepatitis C virus infections. 62 Changes in NK cells subset of elderly are associated with: a) increased numbers of NK in healthy elderly individuals, b) reduced frequencies of CD56bright NK cells and increase of CD56dimCD16C NK cells.…”

Section: B-cells Responsementioning

confidence: 99%

“…62 There is a third compartment of dysfunctional NK cells, CD56¡CD16C, also found in a small percentage in peripheral blood of healthy individuals, which is expanded in HIV and in hepatitis C virus infections. 62 Changes in NK cells subset of elderly are associated with: a) increased numbers of NK in healthy elderly individuals, b) reduced frequencies of CD56bright NK cells and increase of CD56dimCD16C NK cells. 29,62 These changes drive to a reduction of cytotoxicity-activating receptors and a major susceptibility to infections, also mediated by the reduced ability to respond after stimulation.…”

Section: B-cells Responsementioning

confidence: 99%

“…62 Changes in NK cells subset of elderly are associated with: a) increased numbers of NK in healthy elderly individuals, b) reduced frequencies of CD56bright NK cells and increase of CD56dimCD16C NK cells. 29,62 These changes drive to a reduction of cytotoxicity-activating receptors and a major susceptibility to infections, also mediated by the reduced ability to respond after stimulation. 29,62 In HIV infection NK cells are supposed to have a central role in the complex net of interactions between immune and adaptive responses, as well reported in Scully and Alter's recent paper.…”

Section: B-cells Responsementioning

confidence: 99%

“…29,62 These changes drive to a reduction of cytotoxicity-activating receptors and a major susceptibility to infections, also mediated by the reduced ability to respond after stimulation. 29,62 In HIV infection NK cells are supposed to have a central role in the complex net of interactions between immune and adaptive responses, as well reported in Scully and Alter's recent paper. 63 …”

Section: B-cells Responsementioning

confidence: 99%

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Immunosenescence and hurdles in the clinical management of older HIV-patients

2017

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People living with HIV (PLWH) who are treated with effective highly active antiretroviral therapy (HAART) have a similar life expectancy to the general population. Moreover, an increasing proportion of new HIV diagnoses are made in people older than 50 y. The number of older HIVinfected patients is thus constantly growing and it is expected that by 2030 around 70% of PLWH will be more than 50 y old. On the other hand, HIV infection itself is responsible for accelerated immunosenescence, a progressive decline of immune system function in both the adaptive and the innate arm, which impairs the ability of an individual to respond to infections and to give rise to long-term immunity; furthermore, older patients tend to have a worse immunological response to HAART.In this review we focus on the pathogenesis of HIV-induced immunosenescence and on the clinical management of older HIV-infected patients.

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Section: B-cells Responsementioning

confidence: 99%

Section: B-cells Responsementioning

confidence: 99%

Section: B-cells Responsementioning

confidence: 99%

Section: B-cells Responsementioning

confidence: 99%

Section: B-cells Responsementioning

confidence: 99%

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Immunosenescence and hurdles in the clinical management of older HIV-patients

2017

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Research progress on immune aging and its mechanisms affecting geriatric diseases

Zheng

2019

Aging Medicine

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Immunosenescence , also known as immune aging, refers to the degeneration, compensation, and reconstruction of the immune system with aging. Immune aging is an important factor in the increased susceptibility of the elderly to infectious diseases, malignant tumors, and a variety of chronic diseases and has long been a hotspot in geriatrics and immunology research. In this paper, the characteristics and progression of immune aging are briefly reviewed for clinicians' reference.

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Molecular and biological hallmarks of ageing

Aunan

Watson

Hagland

et al. 2016

British Journal of Surgery

244

149

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Background: Ageing is the inevitable time-dependent decline in physiological organ function that eventually leads to death. Age is a major risk factor for many of the most common medical conditions, such as cardiovascular disease, cancer, diabetes and Alzheimer's disease. This study reviews currently known hallmarks of ageing and their clinical implications.Methods: A literature search of PubMed/MEDLINE was conducted covering the last decade. Results: Average life expectancy has increased dramatically over the past century and is estimated to increase even further. Maximum longevity, however, appears unchanged, suggesting a universal limitation to the human organism. Understanding the underlying molecular processes of ageing and health decline may suggest interventions that, if used at an early age, can prevent, delay, alleviate or even reverse age-related diseases. Hallmarks of ageing can be grouped into three main categories. The primary hallmarks cause damage to cellular functions: genomic instability, telomere attrition, epigenetic alterations and loss of proteostasis. These are followed by antagonistic responses to such damage: deregulated nutrient sensing, altered mitochondrial function and cellular senescence. Finally, integrative hallmarks are possible culprits of the clinical phenotype (stem cell exhaustion and altered intercellular communication), which ultimately contribute to the clinical effects of ageing as seen in physiological loss of reserve, organ decline and reduced function. Conclusion:The sum of these molecular hallmarks produces the clinical picture of the elderly surgical patient: frailty, sarcopenia, anaemia, poor nutrition and a blunted immune response system. Improved understanding of the ageing processes may give rise to new biomarkers of risk or prognosis, novel treatment targets and translational approaches across disciplines that may improve outcomes.

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Immunosenescence: Implications for response to infection and vaccination in older people

Cited by 319 publications

References 63 publications

Immunosenescence and hurdles in the clinical management of older HIV-patients

Immunosenescence and hurdles in the clinical management of older HIV-patients

Research progress on immune aging and its mechanisms affecting geriatric diseases

Molecular and biological hallmarks of ageing

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