2020
DOI: 10.3389/fcimb.2020.00241
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Immunoserological Diagnosis of Human Borrelioses: Current Knowledge and Perspectives

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Cited by 35 publications
(38 citation statements)
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References 107 publications
(173 reference statements)
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“…In fact, we found low rates of optical density for most seropositive horses. Moreover, the DNA detected in sampled horses may be related to infection by B. theileri since (i) bacteremia during B. burgdorferi infection is related as absent or brief (Chang et al, 2000 ; Maraspin et al, 2011 ; Talagrand-Reboul et al, 2020 ), (ii) the primers used here do not distinguish Borrelia species, and (iii) we found R. ( B .) microplus infesting horses.…”
Section: Discussionmentioning
confidence: 77%
“…In fact, we found low rates of optical density for most seropositive horses. Moreover, the DNA detected in sampled horses may be related to infection by B. theileri since (i) bacteremia during B. burgdorferi infection is related as absent or brief (Chang et al, 2000 ; Maraspin et al, 2011 ; Talagrand-Reboul et al, 2020 ), (ii) the primers used here do not distinguish Borrelia species, and (iii) we found R. ( B .) microplus infesting horses.…”
Section: Discussionmentioning
confidence: 77%
“…The predictive value of the serological test depends on the sensitivity and specificity of the test and on the prevalence; a positive serology in a patient who do not present with any objective lesions suggestive of Lyme disease has a predictive value close to zero [ 20 ]. The most frequent limitations and pitfalls of serology are cross-reactions, false IgM positivity, a seronegative window period at the early time of the infection, and serologic scars with a suspicion of reinfection [ 21 ].…”
Section: Discussionmentioning
confidence: 99%
“…This is due to cross-reactivity among Borrelia spp., including LBRF, Lyme disease and other spirochetes (e.g. Treponema pallidum) [30] as well as the fact that serology is not helpful to diagnose acute infection due to the time to seroconversion. Culture of Borrelia spp.…”
Section: Diagnosticsmentioning
confidence: 99%