2008
DOI: 10.4062/biomolther.2008.16.4.351
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Immunosuppressive Effect of Prodigiosin on Murine Splenocyte and Macrophages

Abstract: -Prodigiosin was isolated from marine bacteria Hahella chejuensis which has been recently discovered from Marado, Cheju Island, Republic of Korea. Immunosuppressive properties have been reported for prodigiosin members such as undecylprodigiosin, metacycloprodigiosin, prodigiosin, and its synthetic analogue PNU156804 (PNU). However, the effect of this agent on the function of macrophage and splenocyte has not been characterized in detail. In the present study, we examined the effects of prodigiosin for its abi… Show more

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Cited by 8 publications
(3 citation statements)
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“…, not by preventing IL-2Rα induction but rather by preventing activation of AP-1 and NF-κB. Prodigiosin was also synergistically active when administered with cyclosporine A, each working through different pathways to suppress T-cell activation [ 124 ], while another study found it inhibited macrophage and NK killer cell activities and splenocyte proliferation [ 125 ]..…”
Section: Immunomodulatory Activities Of Prodigiosin and Violaceinmentioning
confidence: 99%
“…, not by preventing IL-2Rα induction but rather by preventing activation of AP-1 and NF-κB. Prodigiosin was also synergistically active when administered with cyclosporine A, each working through different pathways to suppress T-cell activation [ 124 ], while another study found it inhibited macrophage and NK killer cell activities and splenocyte proliferation [ 125 ]..…”
Section: Immunomodulatory Activities Of Prodigiosin and Violaceinmentioning
confidence: 99%
“…The antimalarial activity of PG is mainly reflected in its terminal disinfection on Trypanosoma cruzi, Trypanosoma brucei, Aedes aegypti, and Anopheles stephensi [11,12]. In terms of immunosuppressive activity, Huh et al [13] found that PG alters the function of macrophages and NK cells, as well as the proliferative capacity of splenocytes in mice. Due to the diverse biological activities and high commercial value of PG, there has been an increasing focus on improving its production.…”
Section: Introductionmentioning
confidence: 99%
“…Serratia marcescens [1] can produce prodigiosin (PG), a secondary metabolite, with potential use as a growth inhibitor for many types of cancer cells [2,3]. PG (characterized by a linear tripyrrolic scaffold with the A and B pyrrolic rings connected directly in a bipyrrole unit, and the B and C rings joined in a dipyrrin) has a number of additional important uses as an: immunosuppressive [4], antifungal [5], antibacterial [6], antimalarial [7], and antialgal [8]. PG may even serve as a dye [9].…”
Section: Introductionmentioning
confidence: 99%