“…A study involving in 24 cases with brain metastasis indicated that the patients who underwent comprehensive treatment, such as radiotherapy and chemotherapy, had significantly prolonged survival ( Sun et al, 2020 ). Moreover, much literature has confirmed that immunotherapy and systemic therapy have a significant effect on prolonging the life of patients with metastatic or recurrent cervical cancer ( Lima et al, 2021 , Mountzios et al, 2013 ). Therefore, considering the propensity for disseminated disease, combining multiple therapies, especially systematic treatment, might be a better choice for cervical cancer patients with SEM in good physical condition to prolong survival.…”