Immunotherapy with Wasp Venom is Accompanied by Wide-ranging Immune Responses That Need Further Exploration

Brasch, Jochen; Maidusch, Tzanka

doi:10.2340/00015555-0690

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…In treated patients, VIT leads to a variety of specific immunological changes still being determined. It is unknown, however, which parameter shifts might indicate therapeutic success [26, 27]. The level of specific IgG 4 primarily reflects exposure, and is not recommended in routine assessment [28].…”

Section: Discussionmentioning

confidence: 99%

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Cichocka‐Jarosz¹,

Diwakar²,

Brzyski³

et al. 2011

aoms

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IntroductionVenom immunotherapy (VIT) practice is the definitive treatment for patients with potentially fatal allergic reactions to Hymenoptera stings. The aim is assesing compliance of VIT practice in Poland with the current European Academy of Allergy and Clinical Immunology (EAACI) guidance.Material and methodsA multicentre study was carried out using a structured questionnaire which was sent by post to all VIT practitioners in Poland. Some questionnaire items were altered, in comparison to original version by adding additional answer options or alowing multiple answer option. The response rate was 100%. The obtained results were compared with the published EAACI guidelines.ResultsTwenty-six Polish centres took part in the survey. SSIgE and skin prick tests (SPT) are together used as the first line of investigation, whereas confirmatory intradermal tests (IDT) are applied in half of centres. Only a few centres measure baseline serum tryptase levels. The ultra-rush protocol is preferred. Antihistamine pre-medication is routinely practiced. A target dose equal to 100 µg is used in most centres. A 6-week interval between booster doses is the most frequent. Five years is considered as an optimal VIT duration. Before the VIT completion, SSIgE is evaluated in fifty percent of centres, whereas sting challenge is considered by half of responders.ConclusionsThere are some differences between current practice in Poland and the EAACI recommendations, indicating areas requiring better compliance. Comparision between Poland and the United Kingdom revealed that health service organization and health care funding may play a major role in the provision of allergy services. This may affect the extent to which international guidance may be applied in individual countries. It is worth considering conducting the same survey in other European countries.

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Section: Discussionmentioning

confidence: 99%

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Cichocka‐Jarosz¹,

Diwakar²,

Brzyski³

et al. 2011

aoms

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show abstract

“… 107,108 Nevertheless, monitoring the thresholds of skin reactivity, total serum IgE, specific IgE, specific IgG and specific IgG4 in patients that completed VIT showed that no severe reactions upon field stings were observed when VIT induced changes in at least 3 of these parameters. 109 …”

Section: Allergen-specific Immunotherapy and Monitoring Of Venom Hypementioning

confidence: 99%

Allergen-specific immunotherapy of Hymenoptera venom allergy – also a matter of diagnosis

Schiener

Graessel

Ollert

et al. 2017

Human Vaccines & Immunotherapeutics

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Stings of hymenoptera can induce IgE-mediated hypersensitivity reactions in venom-allergic patients, ranging from local up to severe systemic reactions and even fatal anaphylaxis. Allergic patients' quality of life can be mainly improved by altering their immune response to tolerate the venoms by injecting increasing venom doses over years. This venom-specific immunotherapy is highly effective and well tolerated. However, component-resolved information about the venoms has increased in the last years. This knowledge is not only able to improve diagnostics as basis for an accurate therapy, but was additionally used to create tools which enable the analysis of therapeutic venom extracts on a molecular level. Therefore, during the last decade the detailed knowledge of the allergen composition of hymenoptera venoms has substantially improved diagnosis and therapy of venom allergy. This review focuses on state of the art diagnostic and therapeutic options as well as on novel directions trying to improve therapy.

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“…Several studies have demonstrated that immunotherapy for vespid allergy with venom extracts is clinically effective and improve the quality of life and allergic symptoms. This improvement is correlated to a significant decrease of total IgE levels, and increase in specific IgG and IgG4 levels [119]. However, severe and life-threatening anaphylactic side effects may be induced after the administration of crude allergen extracts [120].…”

Section: Insect Sting Allergymentioning

confidence: 99%

From Molecular Cloning to Vaccine Development for Allergic Diseases

Cantillo¹,

Puerta²

2013

An Integrated View of the Molecular Recognition and Toxinology - From Analytical Procedures to Biomedical Applications

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Immunotherapy with Wasp Venom is Accompanied by Wide-ranging Immune Responses That Need Further Exploration

Cited by 4 publications

References 12 publications

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Allergen-specific immunotherapy of Hymenoptera venom allergy – also a matter of diagnosis

From Molecular Cloning to Vaccine Development for Allergic Diseases

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