Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats

Toxicologic evaluation of chronic feeding of glyphosate-resistant transgenic soybean GTS40-3-2 meal to rats

“…A large number of feeding studies on rodents use standard response variables and are designed to determine whether feeds containing GM crops are substantially equivalent to non-transgenic control feeds in nutrition and composition. Many GM crops have undergone studies that aim to detect adverse effects, including soybeans (Appenzeller et al, 2008;Chukwudebe et al, 2012;Sissener et al, 2009;Wang et al, 2013), tomatoes (Noteborn et al, 1995), cottonseed (Dryzga et al, 2007), rice (Kroghsbo et al, 2008), and maize grain (He et al, 2008(He et al, , 2009Zhu, 2013). The results showed that one or more GM genes were inserted into the plants' genomes without adverse effects.…”

Humoral and cellular immune responses in mice after airway administration ofBacillus thuringiensisCry1Ab and MON810cry1Ab-transgenic maize

“…pest insect resistance, to the recipient plant (reviews in Traavik and Lim Li, 2007). As many GM crops bring new proteins into the food and feed chains, concerns have been raised about potential adverse effects in terms of toxicity (Hammond et al, 2013, Domingo andGine Bordonaba, 2011), impaired nutrition value (EFSA, 2008) and undesirable immune responses (Finamore et al, 2008, Kroghsbo et al, 2008, Adel-Patient et al, 2011, EFSA, 2010, Taylor and Hefle, 2001, Bernstein et al, 2003. In predisposed individuals, immunogenic proteins (i.e.…”

“…The same authors emphasized that the immune responses after intranasal exposure were unique, and suggested that binding of the lectin motifs of Cry proteins to the lectin binding receptors in nasal-associated lymphoid tissue (NALT) might contribute to that (Takata et al, 2000). The immunological potential of airway exposure to Cry1Ab-containing feed debris was directly illustrated, although unintended, when control fed and Cry1Ab-containing rice fed rats kept in the same room all developed Cry1Ab specific antibodies (Kroghsbo et al, 2008). In humans, Cry1Ab specific antibodies have been detected after occupational inhalation of Bt-based insecticidal sprayings (Bernstein et al, 1999, Doekes et al, 2004.…”

Introduction of Genetically Modified Organisms (GMOs) -Health Risks and Benefits for Animals and Citizens of Republic of Macedonia

“…Pusztai and Bardoc (2006), and Ewen and Pusztai, (1999), in the diet of rats as GM foods they used GM potatoes and established excessive growth of the lining of the stomach, pre-cancerous condition, toxic reactions in multiple organ systems and abnormalities in the cells and the structure of the small intestine. Kroghsbo et al (2008), in the diet of rats as GM foods they used GM Bt rice and established that even low levels of contamination of conventional crops with GM Bt toxin can be harmful to the health of animals. Researchers Diels, et al (2011), in this analysis included 94 publications selected through objective criteria, where it was determined that during existence of financial or professional conflict of interest, which were associated with the results of the analysis, genetically modified products are presented subjectively in a positive light.…”