IMP3 combined with CD44s, a novel predictor for prognosis of patients with hepatocellular carcinoma

Zhou, Tianjun; Wu, Xiaofeng; Zhou, Bo; Xu, Zhenchao; Qin, Jianjie; Liang, Hao; Lv, Ling; Gao, Yun; Deng, Lei; Yin, Jie; Li, Guoqiang

doi:10.1007/s00432-014-1639-x

Cited by 38 publications

(23 citation statements)

References 32 publications

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“…The 53 studies involved 8,937 patients with different cancer types, including 6 studies of RCC,8,25–29 6 lung cancer,9,30–34 4 oral cancer,10,35–37 4 urothelial carcinoma,38–41 4 ovarian cancer,16,17,42,43 3 hepatocellular carcinoma (HCC),44–46 4 colorectal cancer,12,47–49 3 prostate cancer,14,15,50 3 pancreatic cancer,51–53 2 gastric cancer,11,54 2 intrahepatic cholangiocarcinoma (ICC),55,56 and one study each of tongue cancer,57 thyroid carcinoma,58 sacral chordoma,59 pilocytic astrocytoma and pilomyxoid astrocytoma (PA/PMA),60 neuroblastoma,61 meningioma,62 melanoma,63 breast cancer,64 giant cell tumor,65 bile duct carcinoma,66 esophageal carcinoma,67 and cervical cancer 13. A total of 25 studies involved Caucasians and 28 involved Asians.…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

Chen¹,

Xie²,

Li³

et al. 2017

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BackgroundAccumulated studies have investigated the prognostic role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in various cancers, but inconsistent and controversial results were obtained. Therefore, we performed a systematic review and meta-analysis to investigate the potential value of IMP3 in the prognostic prediction of human solid tumors.Materials and methodsA systematic literature search in the electronic databases PubMed, Embase, Web of Science, and Cochrane library (updated to April 2016) was conducted to identify eligible studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for survival outcomes were calculated and gathered using STATA 12.0 software.ResultsA total of 53 studies containing 8,937 patients with solid tumors were included in this meta-analysis. High IMP3 expression was significantly associated with worse overall survival (OS) of solid tumors (HR =2.08, 95% CI: 1.80–2.42, P<0.001). Similar results were observed in cancer-specific survival (CSS), disease-free survival (DFS), recurrence-free survival (RFS), progression-free survival (PFS), and metastasis-free survival (MFS). Further subgroup analysis stratified by tumor type showed that elevated IMP3 expression was associated with poor OS in renal cell carcinoma (RCC), lung cancer, oral cancer, urothelial carcinoma, hepatocellular carcinoma (HCC), colorectal cancer, pancreatic cancer, gastric cancer, and intrahepatic cholangiocarcinoma (ICC).ConclusionThe current evidence suggests that high IMP3 expression is associated with poor prognosis in most solid tumors. IMP3 is a potential valuable prognostic factor and might serve as a promising biomarker to guide clinical decisions in human solid tumors.

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Section: Resultsmentioning

confidence: 99%

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

Chen¹,

Xie²,

Li³

et al. 2017

OTT

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“…IMP3 expression was first observed in PDACs (Gress et al 1996) and was associated with up to 97% of invasive tumors (Yantiss et al 2005). Its expression has been reported in most tumors of the hepato-biliary system, including HCCs (Jeng et al 2008;Hu et al 2014), intrahepatic cholangiocarcinoma (Chen et al 2013b), gallbladder carcinomas (Shi et al 2013), and bile duct carcinomas , where it correlates with poor prognosis and invasiveness (Jeng et al 2008). IMP3 expression in HCC mouse models as well as primary human HCC was observed to be highest in CD133 + /CD49f + cells, which display CSC/tumor-initiating cell (TIC) properties (Chen et al 2013a), and has been proposed to enhance HCC cell migration and invasiveness by promoting the expression of HMGA2.…”

Section: Regulation Of Imp Expressionmentioning

confidence: 99%

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

et al. 2016

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IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization, translation, and stability. Three mammalian IMP paralogs (IMP1–3) have been identified that are expressed in most organs during embryogenesis, where they are believed to play an important role in cell migration, metabolism, and stem cell renewal. Whereas some IMP2 expression is retained in several adult mouse organs, IMP1 and IMP3 are either absent or expressed at very low levels in most tissues after birth. However, all three paralogs can be re-expressed upon malignant transformation and are found in a broad range of cancer types where their expression often correlates with poor prognosis. IMPs appear to resume their physiological functions in malignant cells, which not only contribute to tumor progression but participate in the establishment and maintenance of tumor cell hierarchies. This review summarizes our current understanding of the functions of IMPs during normal development and focuses on a series of recent observations that have provided new insight into how their physiological functions enable IMPs to play a potentially key role in cancer stem cell maintenance and tumor growth.

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“…It is well known that CD44 is one of the cell adhesion molecules which closely related cell surface glycoproteins involved in cell–cell interactions. Upregulation of CD44 expression promoted hepatocellular carcinoma and breast cancer cells migrating and invading . CD44 has also been recognized as a cancer stem cells marker in several types of cancer and associated with targeting treatment‐resistant .…”

Section: Discussionmentioning

confidence: 99%

Overexpression of c‐fos promotes cell invasion and migration via CD44 pathway in oral squamous cell carcinoma

Dong

Ye²,

Zhang

et al. 2014

J Oral Pathology Medicine

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BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most deadly malignant tumors with high invasive potential and frequently cervical lymph node metastasis. AP-1 plays a critical role in tumor invasion and metastasis, but there are few reports on the role of c-Fos in OSCC carcinogenesis and metastasis. METHODS: Investigate c-Fos expression in clinical samples from 58 primary patients with OSCC by immunohistochemistry. c-Fos knockdown stable cell lines were established by lentiviral infection and transwell cell invasion assay to detect the effects of c-Fos knockdown on tumor cell invasion. RESULTS: Nuclear and cytoplasmic c-Fos protein were both overexpression in cancerous tissues compared with adjacent non-malignant epithelia (nuclear: P < 0.001, cytoplasmic: P = 0.005). Higher level nuclear c-Fos expression was found in the tumor samples of patients with lymph node metastasis than those without lymph node metastasis (4.85 ± 1.43 vs. 3.61 ± 1.28, P = 0.002). Higher level of c-Fos expression was also found in tumor invasive front margin than tumor center and high nuclear expression of c-Fos indicated poor survival. Knockdown of c-Fos greatly suppressed tumor cell proliferation and invasion and downregulated CD44 and CyclinD1 expression in HN6 and SCC9 cells. However, CyclinD3, c-myc, and Erk1/2 were found no changes to c-Fos depletion. CONCLUSIONS: c-Fos promoted cell invasion and migration via CD44 pathway in OSCC. c-Fos could be used as a potential therapeutic target gene and an additional marker for evaluation of lymph node metastasis.J Oral Pathol Med (2015) 44: 353-360

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IMP3 combined with CD44s, a novel predictor for prognosis of patients with hepatocellular carcinoma

Abstract: Our findings suggest that IMP3 facilitates HCC aggressiveness through regulating CD44s expression, and IMP3 combined with CD44s can be as a new predictor for unfavorable prognosis in HCC patients.

Cited by 38 publications

References 32 publications

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

Overexpression of c‐fos promotes cell invasion and migration via CD44 pathway in oral squamous cell carcinoma

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