Impact of a premature menopause on cognitive function in later life

Ryan, Joanne; Scali, Jacqueline; Carrière, Isabelle; Amieva, Hélène; Rouaud, Olivier; Berr, Claudine; Ritchie, Karen; Ancelin, Marie-Laure

doi:10.1111/1471-0528.12828

Cited by 162 publications

(127 citation statements)

References 65 publications

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“…76 Many other trials also support that the age at the time of surgical or natural menopause plays a critical factor in brain health and cognitive function. [77][78][79][80][81] Premature Surgical Menopause menopause, often defined as menopause at less than 40 years of age, has been associated with a decline of global cognition. 79 A significant decrease in global cognition has been related to younger age at bilateral oophorectomy in several large-scale studies.…”

Section: Bone Loss Osteoporosis and Fracture Riskmentioning

confidence: 99%

“…[77][78][79][80][81] Premature Surgical Menopause menopause, often defined as menopause at less than 40 years of age, has been associated with a decline of global cognition. 79 A significant decrease in global cognition has been related to younger age at bilateral oophorectomy in several large-scale studies. 80,81 One report found a significant increase in Alzheimer disease and neuritic plaques in women who had undergone surgical versus natural menopause.…”

Section: Bone Loss Osteoporosis and Fracture Riskmentioning

confidence: 99%

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Surgical Menopause

Rodríguez

Shoupe

2015

Endocrinology and Metabolism Clinics of North America

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In addition to the common symptoms that occur after natural menopause, special considerations apply to women who have had their ovaries removed, particularly when oophorectomy occurs before age 45 years. Women with premenopausal oophorectomy have more severe and prolonged menopausal symptoms. Their risks of adverse mood, heart disease, excessive bone resorption, sexual dysfunction, and cognitive disorders are increased compared with the general population. Retention of the ovaries carries a survival benefit for women at low risk of ovarian malignancy. Women facing oophorectomy should understand the balance of risks and benefits in order to make an informed decision.

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Section: Bone Loss Osteoporosis and Fracture Riskmentioning

confidence: 99%

Section: Bone Loss Osteoporosis and Fracture Riskmentioning

confidence: 99%

Surgical Menopause

Rodríguez

Shoupe

2015

Endocrinology and Metabolism Clinics of North America

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“…A premature menopause, either because of a premature bilateral ovariectomy or a premature ovarian failure, was associated with worse verbal fluency and visual memory in later life and also with a 30% increased risk of decline in psychomotor speed and global cognitive function over 7 years [99]. Hormone replacement therapy at the time of premature menopause appeared only partly beneficial for later-life cognitive functioning, and Ryan et al warn that this should be considered as a part of risk/benefit ratio when deciding on ovariectomy in younger women [99].…”

Section: Cognitive Impairmentmentioning

confidence: 99%

“…Hormone replacement therapy at the time of premature menopause appeared only partly beneficial for later-life cognitive functioning, and Ryan et al warn that this should be considered as a part of risk/benefit ratio when deciding on ovariectomy in younger women [99].…”

Section: Cognitive Impairmentmentioning

confidence: 99%

Reproductive Aging: Perimenopause and Psychopathological Symptoms

Geršak¹,

Gersak²,

Turčin³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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The female reproductive axis essentially comprises of the hypothalamic-pituitaryovarian axis and the mullerian-derived structures. The reproductive axis ages to a nonfunctional state (menopause) much earlier than the other organ systems do, at a time when a woman is otherwise healthy. The basis of reproductive senescence in women is oocyte depletion in the ovary. Perimenopause is defined by menstrual cycle and endocrine changes, such as disturbed ovarian-pituitary-hypothalamic feedback relationships, inaccurate estrogen levels, and decreased progesterone levels. Many psychopathological changes can take place, but most commonly women experience mild cognitive impairment, anxiety, irritability, mood swings, and depression. Estrogens influence depression and depressive-like behavior through interactions with neurotropic factors and through an influence on the serotonergic system.

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“…In a French, population-based cohort study of 4868 women, both spontaneous and iatrogenic POI were associated with negative effects on cognitive function in later life including increased risk of poor verbal fluency and impaired visual memory. There was no clear evidence that use of HT reduced the risk of cognitive decline but HT use was self-reported at the age of at least 65 years and therefore recall bias may have affected the results [95]. …”

mentioning

confidence: 99%

Current Concepts in Premature Ovarian Insufficiency

Maclaran

Panay

2015

Womens Health (Lond Engl)

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Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Unfortunately, there are many deficiencies in our understanding of the condition as the underlying etiology and optimum management strategies are poorly understood. Improved awareness of POI and its long-term implications has led to increased research interest in recent years. Current research has allowed a greater understanding of the changing epidemiology in POI, genetic factors in its etiology and randomized controlled trials of hormone therapy are underway to provide evidence for treatment. This article reviews the latest literature on POI to summarize current understanding and future directions. Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences, affecting approximately one in 100 women by the age of 40 years [1]. Unfortunately, there are many deficiencies in our understanding of the condition as the underlying etiology and optimum management strategies are poorly understood. Furthermore, controversy exists surrounding the terminology and diagnostic criteria, all of which can have a significant impact on the patients' well-being.Improved awareness of POI and its longterm implications has led to increased research interest in recent years. Current research has allowed a greater understanding of the changing epidemiology in POI, genetic factors in its etiology and randomized controlled trials (RCTs) of hormone therapy (HT) are underway to provide evidence for treatment. Here we aim to review the latest literature on POI to summarize current understanding and future directions. TerminologyThere has been a long-standing lack of consensus over the nomenclature of the disorder, with a variety of other terms in use, such as primary ovarian insufficiency, premature ovarian failure, premature menopause and hypergonadotrophic hypogonadism. We use the term premature ovarian insufficiency as it encompasses both spontaneous POI and the increasing number of women who have suffered POI as a result of iatrogenic interventions. The term insufficiency, rather than failure, is thought to more accurately reflect the unpredictable nature of ovarian function in the disorder as intermittent ovarian function, resulting in ovulation and even pregnancy, can occur [2,3]. The use of the term 'premature' refers to the timeline rather than the etiology, that is, ovarian insufficiency which has occurred before 40 years of age from any cause. It is important to note, however, that the condition does not always develop by the same mechanism as the normal menopause, which is due to follicle depletion. For example, some women develop POI due to mutations in the follicle stimulating hormone (FSH) receptor -these women have follicles in the ovary that are unable to function. Another example is steroidogenic cell POI has traditionally been defined as the triad of amenorrhea, elevated gonadotrophins and estrogen deficiency occurring in women under the age...

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Impact of a premature menopause on cognitive function in later life

Cited by 162 publications

References 65 publications

Surgical Menopause

Surgical Menopause

Reproductive Aging: Perimenopause and Psychopathological Symptoms

Current Concepts in Premature Ovarian Insufficiency

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