Impact of Adding Mean Apparent Diffusion Coefficient (ADCmean) Measurements to O-RADS MRI Scoring For Adnexal Lesions Characterization: A Combined O-RADS MRI/ADCmean Approach

Elshetry, Al Shaimaa Fathi; Hamed, Enas Mahmoud; Frere, Reem Abdel Fattah; Zaid, Nesma Adel

doi:10.1016/j.acra.2022.07.019

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…Our data are in agreement with the results of recently published studies that reported a sensitivity of the O-RADS MRI score between 85.6% and 93.5% and a specificity between 84.6% and 97.5% [5,9,[22][23][24][25][26][27][28][29].…”

Section: Discussionsupporting

confidence: 93%

“…In a prospective study, Elshetry et al analysed 116 adnexal lesions. They reported optimal thresholds to predict malignant adnexal lesions O-RADS MRI score > 3 and ADC mean value ≤ 1.08 × 10 3 mm 2 /s obtaining a reduction of false positives, a significant increase in the specificity (97.1%, p = 0.005), PPV (95.4%, p = 0.002) and PLR (33.1, p < 0.0001), and nonsignificant change in the AUC (0.953, p = 0.252) and sensitivity (93.3%, p = 0.467) [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Impact of DWI and ADC values in Ovarian-Adnexal Reporting and Data System (O-RADS) MRI score

et al. 2023

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Purpose Introduce DWI and quantitative ADC evaluation in O-RADS MRI system and observe how diagnostic performance changes. Assess its validity and reproducibility between readers with different experience in female pelvic imaging. Finally, evaluate any correlation between ADC value and histotype in malignant lesions. Materials and Methods In total, 173 patients with 213 indeterminate adnexal masses (AMs) on ultrasound were subjected to MRI examination, from which 140 patients with 172 AMs were included in the final analysis. Standardised MRI sequences were used, including DWI and DCE sequences. Two readers, blinded to histopathological data, retrospectively classified AMs according to the O-RADS MRI scoring system. A quantitative analysis method was applied by placing a ROI on the ADC maps obtained from single-exponential DWI sequences. AMs considered benign (O-RADS MRI score 2) were excluded from the ADC analysis. Results Excellent inter-reader agreement was found in the classification of lesions according to the O-RADS MRI score (K = 0.936; 95% CI). Two ROC curves were created to determine the optimal cut-off value for the ADC variable between O-RADS MRI categories 3–4 and 4–5, respectively, 1.411 × 10–3 mm2/sec and 0.849 × 10–3 mm2/sec. Based on these ADC values, 3/45 and 22/62 AMs were upgraded, respectively, to score 4 and 5, while 4/62 AMs were downgraded to score 3. ADC values correlated significantly with the ovarian carcinoma histotype (p value < 0.001). Conclusion Our study demonstrates the prognostic potential of DWI and ADC values in the O-RADS MRI classification for better radiological standardisation and characterisation of AMs.

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