Impact of annular and supra-annular CoreValve deployment locations on aortic and coronary artery hemodynamics

Kandail, Harkamaljot S.; Trivedi, Setu; Shaikh, Armaan; Bajwa, Tanvir; O’Hair, Daniel; Jahangir, Arshad; LaDisa, John F.

doi:10.1016/j.jmbbm.2018.06.032

Cited by 47 publications

(34 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The idealized approach aims at the investigation of numerical methodologies, technical aspects and specific clinical questions, with simplified models of complex structures [23,24,33,34,[25][26][27][28][29][30][31][32]. The patient-specific approach is characterized by the segmentation and reconstruction of the anatomical geometry from computed tomography (CT) or magnetic resonance imaging [17,35,[44][45][46][47][48][49][50][51][52][53]36,[54][55][56][37][38][39][40][41][42][43]. This approach is more labor-intensive and time-consuming as compared to the first one but in favor of a more realistic representation of the clinical situation.…”

Section: Introductionmentioning

confidence: 99%

“…TAVR was also compared to the conventional surgical valve replacement with FSI simulations in terms of leaflet stresses and thromboresistance profile [59]. To the best of our knowledge, there are only two FSI works on the complete TAVR procedure [48,54]. In both studies, the deployment of the complete device, frame, leaflets, and skirt was performed.…”

Section: Introductionmentioning

confidence: 99%

“…However, the patient-specific domain was simplified by considering the aorta as a rigid part [54] or with a linear elastic material law [48]. In both cases, the native valve and calcification were neglected, and the boundary conditions applied to the fluid domain were not patient-specific, in particular idealized pressure curves [48] or from specific lumped-parameter models [54]. In this context, the aim of this work is the development of a robust framework to perform patient-specific FSI simulations of self-expandable transcatheter aortic valves.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

On the Modeling of Patient-Specific Transcatheter Aortic Valve Replacement: A Fluid–Structure Interaction Approach

Luraghi¹,

Migliavacca²,

García

et al. 2019

Cardiovasc Eng Tech

View full text Add to dashboard Cite

Purpose-Transcatheter aortic valve replacement (TAVR) is a minimally invasive treatment for high-risk patients with aortic diseases. Despite its increasing use, many influential factors are still to be understood and require continuous investigation. The best numerical approach capable of reproducing both the valves mechanics and the hemodynamics is the fluid-structure interaction (FSI) modeling. The aim of this work is the development of a patient-specific FSI methodology able to model the implantation phase as well as the valve working conditions during cardiac cycles. Methods-The patient-specific domain, which included the aortic root, native valve and calcifications, was reconstructed from CT images, while the CAD model of the device, metallic frame and pericardium, was drawn from literature data. Ventricular and aortic pressure waveforms, derived from the patient's data, were used as boundary conditions. The proposed method was applied to two real clinical cases, which presented different outcomes in terms of paravalvular leakage (PVL), the main complication after TAVR. Results-The results confirmed the clinical prognosis of mild and moderate PVL with coherent values of regurgitant volume and effective regurgitant orifice area. Moreover, the final release configuration of the device and the velocity field were compared with postoperative CT scans and Doppler traces showing a good qualitative and quantitative matching. Conclusion-In conclusion, the development of realistic and accurate FSI patient-specific models can be used as a support for clinical decisions before the implantation.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

On the Modeling of Patient-Specific Transcatheter Aortic Valve Replacement: A Fluid–Structure Interaction Approach

Luraghi¹,

Migliavacca²,

García

et al. 2019

Cardiovasc Eng Tech

View full text Add to dashboard Cite

show abstract

“…The SPH approach [29], however, cannot fully impose incompressibility, and prescribing boundary conditions is di cult. In addition, several studies have used cut-cell-like methods [30][31][32] to simulate valve FSI, but these studies also used linearly elastic leaflet models and have not yet been validated.…”

Section: Introductionmentioning

confidence: 99%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Lee¹,

Rygg²,

Kolahdouz³

et al. 2019

Preprint

View full text Add to dashboard Cite

Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid--structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.

show abstract

“…ALE and SPH methods are usually used to study blood flow within cardiovascular vessel and its interaction with rigid body movements such as mechanical valve [9]- [11]. However, the instability of adaptive remeshing algorithm, high calculation expense, and tedious definition process, limit their use for simulation of bio-prosthesis valve [12], which involves complex contact and FSI problem during transient calculation. IBM method was introduced by Peskin [13] in 1972, in which the compatibility requirement for the fluid and structure interfaces could be waived by translating the interaction between the two materials to penalty forces, and applied to the nodes near the interface.…”

Section: Introductionmentioning

confidence: 99%

Computational Modeling for Surgical Reconstruction of Aortic Valve by Using Autologous Pericardium

et al. 2020

View full text Add to dashboard Cite

The objective of this study was to evaluate the clinical effectiveness of surgical reconstruction of aortic valve using autologous pericardium, and the hemodynamic impact of matching the circumferential direction of the trimmed leaflet to inherent fiber orientation of the pericardium during surgery. A patient specific aortic valve model was built based on CTA data. The reconstructive surgery was carried out on the model following normal operating procedures. FSI simulation was performed to analyze the hemodynamic characteristics among the diseased model, normal model and three operative models with different misaligned angles between the circumferential direction of the substitute and inherent fiber orientation. The differences of EOA, velocity distribution, stress and strain on leaflets, and the valve deformation between the five models were compared and analyzed. The results showed that reconstructive surgery helps enlarge EOA, reduce abnormity of leaflet motion and blood ejection compared to diseased model. There was no significant difference between operative models with different misaligned angles in terms of leaflet motion and flow pattern, but as the misaligned angle increased, greater strain and deformation were observed on leaflets during the diastolic period. The present study demonstrated the instant clinical effectiveness of the reconstructive surgery of aortic valve by the improvement of EOA and flow pattern, and suggested that during the operation it may be unnecessary to match the circumferential direction of the substitute to inherent fiber orientation of the pericardium since the hemodynamic characteristics were insensitive to the fiber alignment, but the strain and deformation increment on the substitutes during diastolic period still raised concern about their durability.

show abstract

Impact of annular and supra-annular CoreValve deployment locations on aortic and coronary artery hemodynamics

Cited by 47 publications

References 44 publications

On the Modeling of Patient-Specific Transcatheter Aortic Valve Replacement: A Fluid–Structure Interaction Approach

On the Modeling of Patient-Specific Transcatheter Aortic Valve Replacement: A Fluid–Structure Interaction Approach

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Computational Modeling for Surgical Reconstruction of Aortic Valve by Using Autologous Pericardium

Contact Info

Product

Resources

About