Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma

Swanson, Hollie I.; Choi, Eunyoung; Helton, W. Brian; Gairola, C. Gary; Valentino, Joseph

doi:10.1016/j.oooo.2013.10.012

Cited by 21 publications

(16 citation statements)

References 34 publications

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“…Oral squamous cell carcinomas (OSCC) is the sixth most prevalent cancer worldwide [104]. In in vitro studies, kaempferol displayed antiproliferative effect on pharynx (FaDu) and oral cavity carcinoma (PCI-13) [105], human esophageal squamous carcinoma (Eca-109), and human tongue squamous carcinoma (SCC4, SCC-1483, SCC-25, SCC-QLL1) cells, prevented clone formation and cell migration and invasion, and induced substantial apoptosis [104,106,107,108]. Kaempferol also caused cell cycle arrest at G0/G1 phase and downregulated Bcl-2, MMP-2, c-Jun, and hexokinase-2 expression.…”

Section: Anticancer Properties Of Kaempferolmentioning

confidence: 99%

Kaempferol: A Key Emphasis to Its Anticancer Potential

et al. 2019

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A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.

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Section: Anticancer Properties Of Kaempferolmentioning

confidence: 99%

Kaempferol: A Key Emphasis to Its Anticancer Potential

et al. 2019

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“…Moreover, it suppresses invasion and metastasis and downregulates the c‐Met/p38 signaling pathway (Dang et al, ; Nepal et al, 2013). Kaempferol additionally reduces the viability, tumor growth, and tumor size in different human cancer cell lines including pharynx (FaDu cell line), metastatic lymph node (PCI‐15B cell line), oral cavity carcinoma (PCI‐13 cell line), and explanted FaDu cells (Swanson, Choi, Helton, Gairola, & Valentino, ). Other studies verified the preventive role of kaempferol against renal cell carcinoma (RCC) lines (786‐O and 769‐P cells) through multiple mechanisms such as inhibition of cell growth, induction of apoptotic cell death and cell cycle arrest, upregulation of p21 and downregulation of cyclin B1 expressions, inhibition of activation of EGFR/p38 signaling pathways, and activation of PARP cleavages (Song et al, ).…”

Section: Health Perspectivesmentioning

confidence: 99%

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Imran

Rauf

Shah

et al. 2018

Phytotherapy Research

268

154

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Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2). Accordingly, the aim of the present review is to collect information pertaining to the effective role of kaempferol against various degenerative disorders, summarize the antioxidant, anti-inflammatory, anticancer, antidiabetic, and antiaging effects of kaempferol and to review the progress of recent research and available data on kaempferol as a protective and chemotherapeutic agent against several ailments.

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“…1 In recent years, more and more studies have reported that apigenin possesses a wide range of biological activities, including anti-allergic, anti-microbial, anti-inflammatory, anti-viral, and anti-tumor functions. 3,4 Apigenin showed outstanding anticancer effect on various cancers such as breast cancer, 5 prostate cancer, 6 head and neck squamous cell carcinoma, 7 and so on. Compared with other flavonoids with similar structure, apigenin has low intrinsic toxicity and differential effects in normal versus cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

et al. 2015

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Apigenin, abundantly present in fruits and vegetables, is recognized as a flavonoid with anti-inflammatory, antioxidant and anticancer properties. In this study, we first investigated the anti-neoplastic effects of apigenin on papillary thyroid carcinoma (PTC) cell line BCPAP cells. Our results show that apigenin inhibited the viability of BCPAP cells in a dose-dependent manner. A large body of evidence demonstrates that autophagy contributes to cell death in certain contexts. In the present study, autophagy was induced by apigenin treatment in BCPAP cells, as evidenced by Beclin-1 accumulation, conversion of LC3 protein, p62 degradation as well as the significantly increased formation of acidic vesicular organelles (AVOs) compared to the control group. 3-MA, an autophagy inhibitor, rescued the cells from apigenin-induced cell death. Notably, apigenin enhanced production of reactive oxygen species (ROS), and subsequent induction of significant DNA damage as monitored by the TUNEL assay. In addition, apigenin treatment caused a significant accumulation of cells in the G2/M phase via down-regulation of Cdc25C expression. Our findings reveal that apigenin inhibits papillary thyroid cancer cell viability by the stimulation of reactive oxygen species (ROS) production, induction of DNA damage, leading to G2/M cell cycle arrest followed by autophagic cell death. Thus, our results provide new insights into the molecular mechanisms underlying apigenin-mediated autophagic cell death and suggest apigenin as a potential chemotherapeutic agent which is able to fight against papillary thyroid cancer.

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Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma

Cited by 21 publications

References 34 publications

Kaempferol: A Key Emphasis to Its Anticancer Potential

Kaempferol: A Key Emphasis to Its Anticancer Potential

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

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