Impact of benzodiazepines administration on selected biochemical parameters of albino Wistar rats (Rattus rattus)

Nzor, Joyce Nonubari; Uwakwe, A. A.; Onuoha, S.C.

doi:10.4103/epj.epj_26_17

Cited by 4 publications

(10 citation statements)

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“…To the best of our knowledge, studies on the effects of benzodiazepine poisoning on blood glucose level-especially in the pure form and without other drugs are scarce. Nzor et al explored Wistar rats and observed no significant decrease in serum glucose concentration at different concentrations of di-azepam and bromazepam [7], which contradicts the findings of the present study.…”

Section: Discussioncontrasting

confidence: 99%

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Hypoglycemia in Patients With Pure Benzodiazepine Poisoning

Goudarzi

Mousavi‐Roknabadi

Abdollahpour

et al. 2021

IJMTFM

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Background: Various studies investigated the effects of benzodiazepines on insulin and blood glucose levels and provided contradictory results. The present study aimed to evaluate the clinical effects of benzodiazepine poisoning on hypoglycemia. Methods: This retrospective cross-sectional study (from 22/June/2018 to 22/December/2018) was conducted on all medical records of adult patients with benzodiazepine poisoning who were referred to Ali-Asghar Hospital. The required data were collected using a data-gathering form and then analyzed. Results: In total, 61 patients were enrolled in this study. Furthermore, 19 (31.2%) patients developed hypoglycemia. Besides, 50 (82%) patients used benzodiazepine for a suicide attempt, i.e. higher in patients with hypoglycemia (P<0.0001). Multivariate logistic regression test data indicated that benzodiazepine consumption for suicide attempt (OR=47.978, P=0.001, 95%CI, 5.313-433.277), and the respiratory rate at the time of suicide (OR=0.549, P=0.023, 95%CI, 0.328-0.920) were predictive factors for hypoglycemia in patients with benzodiazepine poisoning. Conclusion: Our study data suggested that 31% of patients who were poisoned with benzodiazepines developed hypoglycemia. The suicidal use of drugs and respiratory rates were predictive factors for hypoglycemia in these patients.

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Section: Discussioncontrasting

confidence: 99%

“…The effect of benzodiazepines on insulin and blood glucose levels has been extensively studied and provided contradictory results [5][6][7][8]. To the best of our knowledge, no studies have investigated the effect of high-dose benzodiazepines or poisoning.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemia in Patients With Pure Benzodiazepine Poisoning

Goudarzi

Mousavi‐Roknabadi

Abdollahpour

et al. 2021

IJMTFM

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“…Oral diazepam treatment in rats had a signifi cant effect on the changes in the values of biochemical parameters in our study. In our study the concentration of total blood proteins of rats increased in treated group as well as in the study of Nzor et al [25] who treated rabbits with a dose of 0.0036 mg diazepam per 100 g body weight. In our study, the increase in triglycerides and cholesterol in blood of diazepam-treated rats compared to control group coincides with literature where photoperiodic rhythm of diazepam-treated rats was tested and leads to an increase in lipids and triglycerides [20].…”

Section: Discussionsupporting

confidence: 85%

“…Decreased erythrocyte and leukocyte parameters are indicative of the depressant effect of diazepam on hematopoiesis and immunity of diazepam-treated rats. Literature data indicate that treatment of rats with diazepam may on one hand increase [20,21], on the other hand decrease [22,23] or not affect the change in the values of hematological parameters of rat blood [24,25]. Different results in literature are present due to usage of different doses and timeline of diazepam administration in experimental protocols.…”

Section: Discussionmentioning

confidence: 99%

Effects of Diazepam on Hematological and Histological Parameters in Rats /in Vivoand Unbiased Stereological Investigation

et al. 2022

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Diazepam-based drugs are widely used today in human treatment. Diazepam may be a primary drug aimed at treating neurological diseases or an associated drug in the treatment of other diseases in the purpose of symptomatic therapy. The sedative effect of diazepam characterizes it as a drug that people usually use on their own and without a doctor’s supervision. Directly, but also through influencing the nervous system, diazepam disrupts proper functioning of all body organs. The purpose of this paper was to examine the effects of diazepam on blood and cytohistological parameters of rats in an in vivo experiment. Mallory-Azan and immunochistochemical staining methods BLX-CX and Survivin tissues of liver, kidney and spleen of rats were used to achieve the set goal. Cytometric analysis of rats detected cells in apoptosis and measurements of stereological parameters were made using a system according to Cavalier’s principle. Results of analysis of hematological and histological parameters indicate a detrimental effect of diazepam on blood parameters, as well as on structure and functioning of the liver, kidneys and spleen of rats. This paper is a foundation for further detailed scientific research with the aim of elucidating all harmful effects that diazepam has on all organs in the body of rats. This data could serve as a starting point for future studies in clinical pharmacology on therapeutic protocols for usage of diazepam-based sedatives.

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“…In spite of the significant effect of GABA on blood glucose, Nzor et al ., the study showed an insignificant effect of bromazepam and diazepam on blood glucose. [ 38 ] Furthermore, midazolam attenuates hyperglycemia-induced endothelial injury by inhibition of vascular endothelial growth factor (VEGF) in diabetic mice since; midazolam improves endothelial function indirectly through activation of endothelial GABA which counteracts oxidative stress-induced endothelial injury. [ 39 40 ]…”

Section: Methods and Search Strategymentioning

confidence: 99%