Impact of blood urea nitrogen for long-term risk stratification in patients with coronary artery disease undergoing percutaneous coronary intervention

Kawabe, Masayuki; Sato, Akira; Hoshi, Tomoya; Sakai, Shunsuke; Hiraya, Daigo; Watabe, Hiroaki; Kakefuda, Yuki; Ishibashi, Mayu; Asaoka, Daisuke; Takeyasu, Noriyuki; Aonuma, Kazutaka

doi:10.1016/j.ijchv.2014.06.002

Cited by 8 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood urea is also a central biomarker in seriously ill patients who do not have acute heart failure 38 . It may show hemodynamic deterioration as well as neurohormonal activation of the sympathetic nervous system, renin‐angiotensin‐aldosterone system, and secretion of arginine vasopressin 39 . Despite the longstanding recognition of renal insufficiency as a risk factor for CVDs, particularly coronary artery disease, in our study, blood/serum creatinine did not emerge as a significant predictor.…”

Section: Discussioncontrasting

confidence: 73%

Risk assessment for mortality in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention: A retrospective cohort study

Oraii,

Shafeghat,

Ashraf

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

Background and AimsPrimary percutaneous coronary intervention (PCI) is the treatment of choice in ST‐elevation myocardial infarction (STEMI) patients. This study aims to evaluate predictors of in‐hospital and long‐term mortality among patients with STEMI undergoing primary PCI.MethodsIn this registry‐based study, we retrospectively analyzed patients with STEMI undergoing primary PCI enrolled in the primary angioplasty registry of Sina Hospital. Independent predictors of in‐hospital and long‐term mortality were determined using multivariate logistic regression and Cox regression analyses, respectively.ResultsA total of 1123 consecutive patients with STEMI were entered into the study. The mean age was 59.37 ± 12.15 years old, and women constituted 17.1% of the study population. The in‐hospital mortality rate was 5.0%. Multivariate analyses revealed that older age (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.02–1.10), lower ejection fraction (OR: 0.97, 95% CI: 0.92–0.99), lower mean arterial pressure (OR: 0.95, 95% CI: 0.93–0.98), and higher white blood cells (OR: 1.17, 95% CI: 1.06–1.29) as independent risk predictors for in‐hospital mortality. Also, 875 patients were followed for a median time of 21.8 months. Multivariate Cox regression demonstrated older age (hazard ratio [HR] = 1.04, 95% CI: 1.02–1.06), lower mean arterial pressure (HR = 0.98, 95% CI: 0.97–1.00), and higher blood urea (HR = 1.01, 95% CI: 1.00–1.02) as independent predictors of long‐term mortality.ConclusionWe found that older age and lower mean arterial pressure were significantly associated with the increased risk of in‐hospital and long‐term mortality in STEMI patients undergoing primary PCI. Our results indicate a necessity for more precise care and monitoring during hospitalization for such high‐risk patients.

show abstract

Section: Discussioncontrasting

confidence: 73%

Risk assessment for mortality in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention: A retrospective cohort study

Oraii,

Shafeghat,

Ashraf

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…The results showed that there is a significant correlation between liver and kidney function tests with some hemodynamic indices, but there is no significant relationship between these tests with mortality rate of the patients. Kawabe et al [20] showed that there is a relationship between BUN levels and mortality rate [21]; also, Kearney et al [21] showed that there is a direct correlation between high serum creatinine and mortality in heart failure patients [22]. These findings were not parallel with our results that might be due to the size of selected sample and severity of liver and kidney lesions.…”

Section: Discussioncontrasting

confidence: 68%

The Association between Hemodynamic Parameters and Para Clinical Findings with Mortality in Heart Failure

Amin¹

2017

JLPRR

View full text Add to dashboard Cite

The study subjects consisted of 120 patients who underwent right heart catheterization in our institution between March 2010 to April 2014. The results showed that there is a significant correlation between mortality and hemodynamic and paraclinical findings. With regards to the importance of heart failure as one of the most serious factors of mortality, finding the correlation between hemodynamic and paraclinical findings with mortality and morbidity of the patients can be helpful in application of therapeutic approaches. In the present study, we showed that there is a significant correlation between some hemodynamic and paraclinical findings with each other and with mortality that can be used as indices for mortality and morbidity of heart failure patients. But, more studies are needed for finding the correlation between hemodynamic and paraclinical patients with mortality and morbidity of heart failure patients. between referring time and heart graft was 87.09 ±80.05 days and the interval with the patient's mortality was 79.5±61.93 days. Keywords: Hemodynamic and paraclinical findingsHemodynamic and paraclinical findings of the patients are shown in (Tables 1-4). The correlation between hemodynamic parameters and paraclinical findingsThe results showed that there is a significant correlation between HR and paraclinical indices including Ca ,PH , CKMB, ALT, T4, and ESR, also, there is a significant correlation between hemodynamic findings (such as CO,CI,SBP and…) and some paraclinical findings (Table 5). The correlation between laboratory findings with heart transplantationThe results showed that there is a direct correlation between heart graft and hemodynamic and paraclinical findings including CKMB, PP, Aorta Sat, TSH, FT4, FT3 and BS and also there was no significant correlation between heart graft and other evaluating findings. Correlation between hemodynamic findings and paraclinical findings with morbidity During this study, the correlation of hemodynamic and paraclinical findings with mortality was evaluated. 39 patients (32.5%) were available from 120 patients. The results showed that the most frequent referring after 1 month was for 19 patients and the least referring after 12 months was 1 case. Also, there was a significant correlation between mortality and some hemodynamic and paraclinical findings (Table 6). Correlation between hemodynamic and paraclinical findings with mortalityThe results showed that there is a significant correlation between mortality and hemodynamic and paraclinical findings include CKMB, PP, Aorta Sat, CRP, HCo3, Pco2, PH and TIBC DiscussionIn the present study, 120 patients including 80 men (66.67%) and 40 women (33.33%) with mean age of 38.28±15.60 and mean height of 172±10 and mean weight of 70.85±16.19 were included to evaluate the correlation between measured indices in catheterization of right heart and paraclinical findings with mortality and morbidity of patients with chronic heart failure. patients (14.9%) went under heart graft and 15 patients (12.4%) died. ...

show abstract

“…12 Blood urea nitrogen also predicted future adverse events among subjects with acute coronary syndrome and stable coronary artery disease undergoing percutaneous coronary intervention, while GFR was not. 17 The elevations of blood urea nitrogen may be due to systemic hypoperfusion or pre-renal disturbance rather than intrinsic renal dysfunction. 12 The increased urea nitrogen on admission of acute myocardial infarction is an indicator of the reduction in kidney perfusion due to lower cardiac output associated with abrupt myocardial ischemia.…”

Section: Resultsmentioning

confidence: 99%

Blood Urea Nitrogen, Creatinine and Urea Nitrogen-to-creatinine Ratio as Predictors of In-Hospital Adverse Cardiac Events in Acute Myocardial Infarction

Hartopo¹,

Puspitawati²,

Arso³

et al. 2019

JCDR

View full text Add to dashboard Cite

Background: Kidney dysfunction affects cardiovascular outcome in patients with acute myocardial infarction. Creatinine, urea nitrogen and urea nitrogen-to-creatinine ratio (UCR) are kidney biomarkers routinely measured in patients with acute myocardial infarction. Their implication in acute myocardial infarction has not been validated. Aims: The study aims to investigate the association between urea nitrogen, creatinine and UCR and in-hospital adverse cardiac events in patients with acute myocardial infarction. Methodology: The study design was cohort. Subjects were patients with acute myocardial infarction. Blood urea nitrogen and creatinine were measured on admission. The UCR was calculated as ratio of urea nitrogen to creatinine. The observation was performed during hospitalization in ICCU to detect the adverse cardiac events, i.e. death, acute heart failure, cardiogenic shock, reinfarction and rescucitated ventricular arrhytmia. The ROC curve was designed to determine the cutoff point of high urea nitrogen, creatinine and UCR. The bivariate and multivariable analysis were performed to establish the independent predictors of adverse cardiac events. A p value < 0.05 was a limit of statistics significance. Results: The subjects of this research were 424 patients. Among them, 96 subjects (22.6 %) developed in-hospital adverse cardiac events. Subjects with adverse cardiac events had significantly higher level of urea nitrogen, creatinine and UCR. The bivariate analysis showed that high urea nitrogen, high creatinine and high UCR were associated with adverse cardiac events. The multivariable analysis showed only high urea nitrogen as an independent predictor for adverse cardiac events (adjusted OR 3.14 (95 % CI:1.37-7.19, p value 0.007)). Conclusion: High urea nitrogen, creatinine and UCR were associated with increased in-hospital adverse cardiac events. Only high urea nitrogen was an independent predictor for in-hospital adverse cardiac events in patients with acute myocardial infarction.

show abstract

Impact of blood urea nitrogen for long-term risk stratification in patients with coronary artery disease undergoing percutaneous coronary intervention

Cited by 8 publications

References 23 publications

Risk assessment for mortality in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention: A retrospective cohort study

Risk assessment for mortality in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention: A retrospective cohort study

The Association between Hemodynamic Parameters and Para Clinical Findings with Mortality in Heart Failure

Blood Urea Nitrogen, Creatinine and Urea Nitrogen-to-creatinine Ratio as Predictors of In-Hospital Adverse Cardiac Events in Acute Myocardial Infarction

Contact Info

Product

Resources

About