Impact of cervical lymph node dissection on serum TG and the course of disease in TG-positive, radioactive iodine whole body scan-negative recurrent/persistent papillary thyroid cancer

Abstract

In the management of papillary thyroid cancer (PTC), surgery is indicated for locoregional recurrent/persistent disease. In this study, we examined the effect of such surgery on serum TG and the course of the disease in 21 patients with PTC (mean age 38.5 yr), who after the initial surgery and radioactive iodine (RAI) ablation developed high TG (>10 ng/ml) and negative 123I whole body scan (DxWBS). All patients had neck persistent/recurrent PTC that was confirmed by ultrasound-guided fine needle aspiration. Prior to neck re-exploration, radiological studies (chest X-rays, CT scan of the chest, and fluoro-18-deoxyglucose positron emission tomography [FDG-PET]) showed no evidence of distant metastases. TG autoantibodies were negative in 19 patients. Second surgery consisted of unilateral (13 patients) or bilateral (8 patients) modified neck dissection. The mean+/-SE TG prior to neck re-exploration was 184.8+/-79.0 ng/ml and declined after surgery to 127.5+/-59.0 ng/ml (p=0.25). The corresponding TSH values were 150.6+/-23.0 and 143.4+/-20.0 mU/l, respectively (p=0.34). After a mean follow-up of 20.7+/-3 months, TG increased to 168+/-68.0 ng/ml. This increase, however, was NS (p=0.67). The corresponding TSH values were 143.4+/-20.0 and 132.0+/-22.0 mU/l (p=0.27). Following second surgery, only 4 patients achieved remission, the other 17 patients received one or more of the following therapies; RAI (10 patients), third surgery (5 patients), and/or external radiation (7 patients). Thirteen patients continued to have persistent disease and 4 patients showed progressive course of their disease (distant metastases or grossly palpable neck disease). In conclusion, second surgery for recurrent/persistent PTC leads to remission in only a minority of cases but the course of the disease tends to be stable in most cases.

Radioguided Occult Lesion Localization in Patients With Locally Recurrent Papillary Thyroid Carcinoma: How We Do It?

“…The localisation by direct injection of radioactive substance into the lesion is advantageous, but not all lesions are suitable for this procedure due to their anatomic localisations. This problem can be eliminated with pre-operative neck mapping (6). Currently, high resolution USG is being used as a primary technique for the search of regional recurrences of PTC (16,17).…”

“…Micrometastases and residual tumoral tissues must be removed surgically. It has also been demonstrated that the remission of thyroglobulin (Tg) levels after surgery is very frequent (5,6). The treatment continues with radioactive iodine (RAI) ablation.…”

Serum Oncofetal Fibronectin (onfFN) mRNA in Differentiated Thyroid Carcinoma (DTC): Large Overlap between Disease-Free and Metastatic Patients

“…Moreover, the clinical significance of minimally detectable Tg levels is unclear, especially if only detected following TSH stimulation (Cooper et al,2009). Seventy per cent of patients with positive Tg and negative diagnostic total body scan remained disease free during 8 years of follow-up (Alzahrani et al, 2002). In addition, benign sources of Tg secretion have been proposed (Zanotti-Fregonara et al, 2010).…”

Influence of thyroid-stimulating hormone on 18F-fluorodeoxyglucose and 99mTc-methoxyisobutylisonitrile uptake in human poorly differentiated thyroid cancer cells in vitro

“…The GLUT1 1 3 isobutylisonitrile (MIBI) is clinically used [6,7], and its usefulness has been recently revaluated [8,9]. However, the use of 18 F-fl uorodeoxyglucose positron emission tomography ( 18 F-FDG-PET) in thyroid cancer is increasing, because of its superior spatial resolution as compared with SPECT [10][11][12][13][14][15][16][17].…”