Impact of changes in bladder and rectal filling volume on organ motion and dose distribution of the bladder in radiotherapy for urinary bladder cancer

Fokdal, Lars; Honoré, Henriette; Høyer, Morten; Meldgaard, Peter; Fode, Kirsten; Maase, Hans von der

doi:10.1016/j.ijrobp.2003.10.039

Cited by 105 publications

(93 citation statements)

References 24 publications

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“…This motion is the principal source of inaccuracy in bladder radiotherapy (RT), with changes to the bladder volume shown to be closely related to displacement of the target volume (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Bladder Motion for Clinical Radiotherapy Practice Using Cine–Magnetic Resonance Imaging

McBain¹,

Khoo²,

Buckley³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Introductionmentioning

confidence: 99%

Assessment of Bladder Motion for Clinical Radiotherapy Practice Using Cine–Magnetic Resonance Imaging

McBain¹,

Khoo²,

Buckley³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Consequently, this results in large volumes of normal tissues included in the high dose region. Detailed studies on bladder filling and interfractional movement of the bladder have enabled us to implement an anisotropic margin [9,10]. To safely reduce the margins, individualized margins based on image-guided strategies have been explored [11].…”

mentioning

confidence: 99%

The normal tissue sparing obtained with simultaneous treatment of pelvic lymph nodes and bladder using intensity-modulated radiotherapy

et al. 2009

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“…Cranial movement was greater than caudal movement. Also, Fokdal et al (10) found that bladder movement was most pronounced in the CC direction. Filling volumes of the bladder and rectum had a large impact on bladder movement.…”

Section: Discussionmentioning

confidence: 96%

“…This margin accounts for factors such as daily setup error and variation in the position of the tumor bed based upon bladder and rectal filling (10,11).…”

Section: Introductionmentioning

confidence: 99%

Lipiodol as a Fiducial Marker for Image-Guided Radiation Therapy for Bladder Cancer

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To evaluate Lipiodol as a liquid, radio-opaque fiducial marker for image--guided radiation therapy (IGRT) for bladder cancer. Materials and Methods:Between 2011 and 2012, 5 clinical T2a-T3b N0 M0 stage II-III bladder cancer patients were treated with maximal transurethral resection of a bladder tumor (TURBT) and image-guided radiation therapy (IGRT) to 64.8 Gy in 36 fractions ± concurrent weekly cisplatin-based or gemcitabine chemotherapy. Ten to 15mL Lipiodol, using 0.5mL per injection, was injected into bladder submucosa circumferentially around the entire periphery of the tumor bed immediately following maximal TURBT.The authors looked at inter-observer variability regarding the size and location of the tumor bed (CTV boost ) on computed tomography scans with versus without Lipiodol.Results: Median follow-up was 18 months. Lipiodol was visible on every orthogonal two-dimensional kV portal image throughout the entire, 7-week course of IGRT. There was a trend towards improved inter-observer agreement on the CTV boost with Lipiodol (p = 0.06). In 2 of 5 patients, the tumor bed based upon Lipiodol extended outside a planning target volume that would have been treated with a radiation boost based upon a cystoscopy report and an enhanced computed tomography (CT) scan for staging. There was no toxicity attributable to Lipiodol. Conclusions: Lipiodol constitutes a safe and effective fiducial marker that an urologist can use to demarcate a tumor bed immediately following maximal TURBT. Lipiodol decreases inter-observer variability in the definition of the extent and location of a tumor bed on a treatment planning CT scan for a radiation boost.

show abstract

Impact of changes in bladder and rectal filling volume on organ motion and dose distribution of the bladder in radiotherapy for urinary bladder cancer

Cited by 105 publications

References 24 publications

Assessment of Bladder Motion for Clinical Radiotherapy Practice Using Cine–Magnetic Resonance Imaging

Assessment of Bladder Motion for Clinical Radiotherapy Practice Using Cine–Magnetic Resonance Imaging

The normal tissue sparing obtained with simultaneous treatment of pelvic lymph nodes and bladder using intensity-modulated radiotherapy

Lipiodol as a Fiducial Marker for Image-Guided Radiation Therapy for Bladder Cancer

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