Impact of Common Polymorphisms in Candidate Genes for Insulin Resistance and Obesity on Weight Loss of Morbidly Obese Subjects after Laparoscopic Adjustable Gastric Banding and Hypocaloric Diet

Sesti, Giorgio; Perego, Lucia; Cardellini, Marina; Andreozzi, Francesco; Ricasoli, Cristina; Vedani, Paola; Guzzi, Valeria; Marchi, Monica; Paganelli, Michele; Ferla, Gianfranco; Pontiroli, Antonio E.; Hribal, Marta Letizia; Folli, Franco

doi:10.1210/jc.2005-0404

Cited by 38 publications

(40 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ECW (l) did not change but the increase of ECW/ICW ratio was statistically significant. Moreover, we observed that a significant proportion of patients (15%) had a relatively modest weight loss, similar to previous reported data, 21 and 5% of patients did not lose weight ( Figure 2). A comparable variability in body composition changes after LAGB was also a characteristic of our study.…”

Section: Discussionsupporting

confidence: 92%

“…To date, the relationship between À174G4C IL6 polymorphism and obesity has been investigated by several comparably small studies with inconsistent results. [16][17][18]21,[46][47][48] 54,55 Our data contribute to defining the C(À) carriers as risk subjects because, although they have a lower FM (%) and trunk FM (%), and higher LM (kg), ratio LM/FM, BCM (kg) and RMR, they show a significantly higher risk for cardiovascular diseases at baseline. With regard to fluid distribution, C(À) carriers showed a higher content of TBW (l) and ECW/ICW ratio than C( þ ) carriers.…”

Section: Discussionmentioning

confidence: 75%

“…Sesti et al 21 reported that À174G4C IL-6 polymorphism is associated with increased weight loss in morbidly obese subjects at 6 months follow-up after LAGB. Poitou et al (2005) 19 showed a relationship between À174G4C IL-6 polymorphism and circulating product in morbidly obese subjects, during weight loss after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…20 Previous data demonstrated that genetic factors, such as À174G4C IL-6 polymorphism, which have an important role in the regulation of body weight (BW), may account for differences in the therapeutic response to LAGB. 21 Because of several, but not really exhaustive, data regarding the relevance of IL-6 on body composition and adipose tissue homeostasis regulation, we investigated the role of À174G4C IL-6 polymorphism on the efficacy of weight loss, body composition and fluid distribution changes in obese subjects, evaluated by dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA), at 6 months follow-up after LAGB surgery.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

et al. 2011

View full text Add to dashboard Cite

Background: There is growing evidence that interleukin-6 (IL-6) is linked to the regulation of fat mass (FM). Our previous data define the common À174G4C IL-6 polymorphism as a marker for 'vulnerable' individuals at risk of age-and obesity-related diseases. An association between À174G4C IL-6 polymorphism and weight loss after bariatric surgery has been demonstrated. Objective: We investigated the impact of À174G4C IL-6 polymorphism on weight loss, body composition, fluid distribution and cardiometabolic changes in obese subjects, after laparoscopic adjustable gastric banding (LAGB) surgery. Design and Outcome measures: A total of 40 obese subjects were studied at baseline and at 6 months follow-up after LAGB surgery. Cardiometabolic and genetic assessment of À174G4C IL-6 polymorphism, anthropometric, body composition and fluid distribution analysis were performed. Results: After LAGB surgery, significant reductions in weight (D% ¼ À11.66±7.78, Po0.001), body mass index (Po0.001), total and trunk FM (kg, %) (D% of total FM ¼ À22.22 ± 12.15, Po0.01), bone mineral density (T-score) (Po0.001), resting metabolic rate (RMR) (Po0.01), and total body water and intracellular water (TBW, ICW) (Po0.05) were observed. At baseline, C(À) carriers of IL-6 polymorphism had a significantly higher RMR (Po0.05), free FM (kg), but less total and trunk FM (%), higher body cell mass (BCM), content of TBW (L) and ECW (extracellular water)/ICW ratio compared with C( þ ) carriers (Po0.001). After LAGB, C( þ ) carriers had a significantly stronger reduction of total FM (kg), but lower bone density, compared with C(À) carriers (Po0.05). Conclusions: Beyond the relationship between À174G4C IL-6 polymorphism and body composition, this study provides first evidence about the association of IL-6 variant with fluid distribution, at baseline, and FM and bone density loss in obese subjects at 6 months follow-up after LAGB surgery. LAGB was less effective if the subjects were carrying risk genotypes, C(À) carriers, for obesity, suggesting a role of genetic variations on bariatric surgery outcomes.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Patients homozygous for the C allele had increases in IL-6 levels post-surgery, whereas G carriers had decreases. In an alternate study of weight loss following gastric banding surgery, homozygous carriers of the G allele lost significantly more weight than GC or CC subjects (Sesti et al, 2005). This suggests that GG carriers may respond more favorably to gastric surgery interventions (that is, better decreases in both body weight and inflammation).…”

Section: Diet-gene Interactions and Adipokines C Stryjecki And Dm Mutchmentioning

confidence: 99%

Fatty acid–gene interactions, adipokines and obesity

Stryjecki

Mutch

2011

Eur J Clin Nutr

View full text Add to dashboard Cite

It is now recognized that the low-grade inflammation observed with obesity is associated with the development of a wide range of downstream complications. As such, there is considerable interest in elucidating the regulatory mechanisms underlying the production of inflammatory molecules to improve the prevention and treatment of obesity and its co-morbidities. White adipose tissue is no longer considered a passive reservoir for storing lipids, but rather an important organ influencing energy metabolism, insulin sensitivity and inflammation by the secretion of proteins, commonly referred to as adipokines. Dysregulation of several adipokines, such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and adiponectin, contributes to the low-grade inflammation that is a hallmark of obesity. Evidence now suggests that fatty acids represent a class of molecules that can modulate adipokine production, thereby influencing inflammatory status. Although the precise molecular mechanisms by which dietary fats regulate adipokine production remain unclear, recent findings indicate that diet-gene interactions may have an important role in the transcriptional and secretory regulation of adipokines. Single-nucleotide polymorphisms in the genes encoding TNF-a, IL-6 and adiponectin can modify circulating levels of these adipokines and, subsequently, obesity-related phenotypes. This genetic variation can also alter the influence of dietary fatty acids on adipokine production. Therefore, the current review will show that it is paramount to consider both genetic information and dietary fat intake to unravel the interindividual variability in inflammatory response observed in intervention protocols targeting obesity.

show abstract

Association of Morbid Obesity With FTO and INSIG2 Allelic Variants

Chu

Erdman²,

Susek³

et al. 2008

Arch Surg

View full text Add to dashboard Cite

show abstract

Impact of Common Polymorphisms in Candidate Genes for Insulin Resistance and Obesity on Weight Loss of Morbidly Obese Subjects after Laparoscopic Adjustable Gastric Banding and Hypocaloric Diet

Abstract: These data demonstrate that genetic factors, which play an important role in the regulation of body weight, may account for differences in the therapeutic response to LAGB.

Cited by 38 publications

References 38 publications

Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

Fatty acid–gene interactions, adipokines and obesity

Association of Morbid Obesity With FTO and INSIG2 Allelic Variants

Contact Info

Product

Resources

About