Impact of estimation versus direct measurement of predonation glomerular filtration rate on the eligibility of potential living kidney donors

Gaillard, F.; Courbebaisse, Marie; Kamar, Nassim; Rostaing, Lionel; Jacquemont, Lola; Hourmant, Maryvonne; Bello, Arnaud Del; Couzi, Lionel; Merville, Pierre; Malvezzi, Paolo; Janbon, Bénédicte; Moulin, Anne‐Marie; Maillard, Nicolas; Dubourg, Laurence; Lemoine, Sandrine; Garrouste, Cyril; Pottel, Hans; Legendre, Christophe; Delanaye, Pierre; Mariat, Christophe

doi:10.1016/j.kint.2018.11.029

Cited by 35 publications

(33 citation statements)

References 24 publications

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“…The European Kidney Function Consortium (EKFC), a new working group under the umbrella of the ERA-EDTA, has taken the initiative to pool and structure data on mGFR, plasma/serum creatinine, age, sex, height and weight of Europeans and non-black North Americans aged ≥18 years. Data were obtained from 11 cohorts ( Supplementary data , Table S1 ) used in ongoing or published cross-sectional and longitudinal studies in France [ 7 , 8 , 23 , 24 ], the UK [ 7–9 , 25 ], Germany [ 7–9 , 26 ], Norway [ 7 , 8 , 27 ], Sweden [ 4 , 6 , 9 , 28 , 29 ] and the USA [ 7 , 8 , 30 , 31 ]. We classified the individual cohorts according to the clinical setting: (i) patients with high prior likelihood of CKD (labelled ‘CKD cohorts’; n = 5) and (ii) patients with low prior likelihood of CKD (labelled ‘community cohorts’; n = 6).…”

Section: Methodsmentioning

confidence: 99%

Prospects for improved glomerular filtration rate estimation based on creatinine—results from a transnational multicentre study

Björk

Nyman

Courbebaisse

et al. 2020

Clinical Kidney Journal

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Abstract Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved. Methods In a cross-sectional analysis covering the years 2003–17, CKD-EPI was validated against measured GFR (mGFR; using various tracer methods) in patients with high likelihood of chronic kidney disease (CKD; five CKD cohorts, n = 8365) and in patients with low likelihood of CKD (six community cohorts, n = 6759). Comparisons were made with the Lund–Malmö revised equation (LMR) and the Full Age Spectrum equation. Results 7In patients aged 18–39 years old, CKD-EPI overestimated GFR with 5.0–16 mL/min/1.73 m2 in median in both cohort types at mGFR levels <120 mL/min/1.73 m2. LMR had greater accuracy than CKD-EPI in the CKD cohorts (P30, the percentage of estimated GFR within 30% of mGFR, 83.5% versus 76.6%). CKD-EPI was generally the most accurate equation in the community cohorts, but all three equations reached P30 above the Kidney Disease Outcomes Quality Initiative benchmark of 90%. Conclusions None of the evaluated equations made optimal use of available data. Prospects for improved GFR estimation procedures based on creatinine exist, particularly in young adults and in settings where patients with suspected or manifest CKD are investigated.

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Section: Methodsmentioning

confidence: 99%

Prospects for improved glomerular filtration rate estimation based on creatinine—results from a transnational multicentre study

Björk

Nyman

Courbebaisse

et al. 2020

Clinical Kidney Journal

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“…Donors were also stratified according to sex, ethnicity, and age below or above 60 years, which is the cut off between standard or extended criteria used in deceased donor organ donation [17]. Mean eGFR was compared using the CKD-EPI equations between groups, as this is recommended in view of the eligibility of potential living donors [18]. The decline in kidney function was analysed between different points of the 60 months follow up and donation.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Donors’ Demographic Characteristics in Renal Function Post-Living Kidney Donation. Analysis of a UK Single Centre Cohort

Bellini

Charalampidis

Stratigos

et al. 2019

JCM

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Introduction: There is a great need to increase the organ donor pool, particularly for living donors. This study analyses the difference in post-living donation kidney function according to pre-donation characteristics of age, genetic relationship with the recipient, sex, ethnicity, and Body Mass Index (BMI). Methods: Retrospective single centre analysis of the trajectory of estimated Glomerular Filtration Rate (eGFR) post-living kidney donation, as a measure of kidney function. Mean eGFR of the different groups was compared at 6 months and during the 60 months follow up. Results: Mean age was 46 ± 13 years, 57% were female, and 60% Caucasian. Mean BMI was 27 ± 5 kg/m2, with more than a quarter of the cohort having a BMI > 30 (26%), and the majority of the donors genetically related to their recipients (56%). The higher decline rate in eGFR was at 6 months after donation, with female sex, non-Caucasian ethnicity, and age lower than 60 years being independently associated with higher recovery in kidney function (p < 0.05). In the 60 months follow up, older age, genetic relationship with the recipient, and male sex led to higher percentual difference in eGFR post-donation. Conclusion: In this study, with a high proportion of high BMI living kidney donors, female sex, age lower than 60 years, and non-genetic relationship with recipient were persistently associated with higher increase in post-donation kidney function. Ethnicity and BMI, per se, should not be a barrier to increasing the living donor kidney pool.

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“…Against this background of uncertainty, Gaillard and colleagues (in this issue) 7 have carried out a retrospective cohort study of potential living kidney donors from 7 transplant centers in France (n ¼ 2733; mean age 51 years; mean mGFR ¼ 96 ml/min per 1.73 m 2 ; 62% female; ancestry unknown) in which both eGFR (calculated by various equations, including the Modification of Diet in Renal Disease, CKD-EPI creatinine, the revised Lund-Malmö, and the Full Age Spectrum) and mGFR (calculated by a variety of reference methods) were assessed (not simultaneously). No cystatin C measurements were undertaken.…”

Section: See Clinical Investigation On Page 896mentioning

confidence: 99%

Evaluation of living donors: quo vadis for GFR criteria?

Glassock

2019

Kidney International

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Impact of estimation versus direct measurement of predonation glomerular filtration rate on the eligibility of potential living kidney donors

Cited by 35 publications

References 24 publications

Prospects for improved glomerular filtration rate estimation based on creatinine—results from a transnational multicentre study

Prospects for improved glomerular filtration rate estimation based on creatinine—results from a transnational multicentre study

The Effect of Donors’ Demographic Characteristics in Renal Function Post-Living Kidney Donation. Analysis of a UK Single Centre Cohort

Evaluation of living donors: quo vadis for GFR criteria?

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