2024
DOI: 10.1002/jbm.a.37671
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Impact of formulation on solid oxygen‐entrapping materials to overcome tumor hypoxia

Megan K. McGovern,
Emily Witt,
Ashley C. Rhodes
et al.

Abstract: Tumor hypoxia, resulting from rapid tumor growth and aberrant vascular proliferation, exacerbates tumor aggressiveness and resistance to treatments like radiation and chemotherapy. To increase tumor oxygenation, we developed solid oxygen gas‐entrapping materials (O2‐GeMs), which were modeled after clinical brachytherapy implants, for direct tumor implantation. The objective of this study was to investigate the impact different formulations of solid O2‐GeMs have on the entrapment and delivery of oxygen. Using a… Show more

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