Impact of human papillomavirus coinfections on the risk of high-grade squamous intraepithelial lesion and cervical cancer

Carrillo-García, Adela; Ponce-de-León-Rosales, Sergio; Cantú-de-León, David; Fragoso-Ontiveros, Verónica; Martínez-Ramírez, Imelda; Orozco-Colín, Asunción; Mohar, Alejandro; Lizano, Marcela

doi:10.1016/j.ygyno.2014.06.018

Cited by 40 publications

(36 citation statements)

References 30 publications

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“…Some reports have proposed that HR‐HPV co‐infections increase the risk to develop high‐grade lesions [Carrillo‐Garcia et al, ]. Although only low‐grade lesions were detected in the study population, both single and multiple HPV infections had a higher prevalence in samples with LSIL, P = 0.001 and P = 0.010, respectively.…”

Section: Discussionmentioning

confidence: 79%

Prevalence of sexually transmitted pathogens associated with HPV infection in cervical samples in a Mexican population

et al. 2015

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Cervical cancer development has been mainly associated with persistent human papillomavirus (HPV) infections. However, HPV infection is unlikely to be sufficient to cause cervical cancer, and the contribution of other sexually transmitted infections (STIs) could be the determining factor for cervical lesion-progression. The aim of this study was to estimate the prevalence of STIs associated with HPV-positivity in 201 cervical samples from patients who underwent annual routine gynecological exams. The overall prevalence of STIs was 57.7%, and the most frequent infection was Ureaplasma spp (UP) (39.8%), followed by Gardnerella vaginalis (GV) (25.9%), α-HPV (18.4%), Chlamydia trachomatis (CT) (1.5%), and Mycoplasma genitalium (MG) (0.5%). The highest prevalence rate of multiple non-HPV infections was observed for the age-range 31-40; for papillomavirus infection, the age-range was 21-30. In normal cervical samples, HPV16 was the most prevalent genotype (24.3%), followed by genotypes 58 (13.5%) and 52 (10.8%). Intriguingly, HPV18 was not detected in the study population, and genotypes 52 and 58 were found exclusively in samples with abnormal cytology. Papillomavirus infection with oncogenic types was significantly associated with GV (P = 0.025) and strongly associated with multiple non-HPV pathogens (P = 0.002). The following variables correlated significantly with cytological diagnosis of low-grade squamous intraepithelial lesion (LSIL): GV (P = 0.028), multiple non-HPV infections (P = 0.001), and high-risk HPV positivity (P = 0.001). Epidemiological data from this study will contribute to the molecular detection of sexually transmitted pathogens from screening programs to identify those women who are at risk for developing cervical lesions.

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Section: Discussionmentioning

confidence: 79%

Prevalence of sexually transmitted pathogens associated with HPV infection in cervical samples in a Mexican population

et al. 2015

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“…A study in Italy showed that in patients with cervical intraepithelial neoplasia the most common co-infections were HPV 16–18 and 51–52, and also co-infections of three genotypes, such as HPV 16–51-52 [38]. In Mexico City, the co-infection of HPV 16 and 68 increases the risk of high-grade lesions and cervical cancer [39]. Our data showed that HPV 16, a genotype with high clinical relevance, co-infects with all genotypes tested, but the most common co-infection was HPV 51–52 (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…The first row of Mexico corresponds to our results. HPV 16, 51, and 52 genotypes were commonly reportedCountry/PopulationHPV genotypes with high prevalenceFrequent co-infectionsRef.Mexico / Mexico City 51, 52, 16, and 33 a 51–52, 16–52, 16–51, and 16-33 a -16, 18, and 6816–68[39]Brazil / Goiânia16, 51, 31, 52, and 1816–18[20]Kingdom of Bahrain52, 16, 31, and 5116–52, 16–31, 16–45, 16–56, and 18–52[19]Italy16, 31, 51, 52, and 616–18, 51–52, 16–51-52, and 31–35-56[38] a Our results …”

Section: Discussionmentioning

confidence: 99%

High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population

et al. 2017

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BackgroundHuman papillomavirus (HPV) is associated with the genesis of cervical carcinoma. The co-infection among HPV genotypes is frequent, but the clinical significance is controversial; in Mexico, the prevalence and pattern of co-infection differ depending on the geographic area of study. We analyzed the mono- and co-infection prevalence of multiple HPV genotypes, as well as preferential interactions among them in a Mexico City sample population.MethodsThis study was designed as a retrospective cohort study. Cervical cytology samples from 1163 women and 166 urethral scraping samples of men were analyzed between 2010 and 2012. The detection of HPV infection was performed using the hybrid capture and the genotyping was by PCR (HPV 6, 11, 16, 18, 30, 31, 33, 35, 45, 51, and 52).Results36% of women were HPV-positive and the most prevalent genotypes were HPV 51, 52, 16, and 33 (42, 38, 37, and 34%, respectively). The prevalence of co-infection was higher (75.37%) than mono-infection in women HPV positives. All genotypes were co-infected with HPV 16, but the co-infection with 51–52 genotypes was the most frequent combination in all cases.ConclusionThe co-infection was very common; each HPV genotype showed different preferences for co-infection with other genotypes, HPV 51–52 co-infection was the most frequent. The HPV 16, 33, 51 and 52 were the most prevalent and are a public health concern to the Mexican population.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3519-7) contains supplementary material, which is available to authorized users.

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“…We assessed the statistical significance between the two groups with the Fisher's exact test (two-tailed P-value ¼ 0.0324).HPV infection is a definite human carcinogen, but only few of the HPV infected population develop cancer, suggesting that other risk factors may play a promoting role. Other STIs can be significant in the carcinogenic pathway of HPV, increasing the risk of cancer and cervical intraepithelial neoplasia caused by HPV [Carrillo-Garc ıa et al, 2014;Magaña-Contreras et al, 2015;Liu et al, 2016].…”

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confidence: 99%

Ureaplasma parvum as a possible enhancer agent of HPV‐induced cervical intraepithelial neoplasia: Preliminary results

Drago

Herzum

Ciccarese

et al. 2016

Journal of Medical Virology

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We read with interest the paper recently published on your journal by Magaña-Contreras et al. [2015] examining the prevalence and the role of sexually transmitted pathogens associated with Human papillomavirus (HPV) infection in cervical samples. However, since the authors were unable to differentiate Ureaplasma parvum (UP) from Ureaplasma urealyticum (UU) in their study, we would like to supplement their observations with the data we collected about HPV-UP co-infection.In a series of 46 asymptomatic patients, who gave written informed consent, examined at the Dermatology Department of the University of Genoa, as part of a screening program on sexually transmitted infections (STIs), we have collected cervical samples, testing them for HPV and UP infection. A cytological evaluation of the samples was also performed.To collect the samples we used the ThinPrep liquidbased cytology preparation system and polymerase chain reaction (PCR) to detect HPV types 6, 11, 16, 18, 31, 33, 35, 39, 40, 42, 43, 44, 45, 51, 52, 53, 58; liquidbased cytology slides were examined by a cytologist at the Galliera Hospital. Furthermore, we collected a second cervical swab that was analyzed with a multiplex-PCR for DNA detection of seven sexually transmitted bacterial pathogens, including UP.Overall, HPV infection was detected in 31 patients, 11 of them had high-risk HPV (HR-HPV). UU infection was detected in three patients: one of them had normal cytology, HPV infection, and no UP infection, two had CIN1 and UP-HPV co-infection.Chlamydia trachomatis (CT) infection was detected in three patients: one of them had normal cytology and UP-HPV co-infection, two had CIN1 and UP-HPV co-infection.Twenty-one patients were positive for UP: three of them (14%) were negative for HPV and eighteen (86%) were co-infected by UP and HPV. Of the 18 patients with UP and HPV co-infection only 2 (11%) had normal cytology whereas 16 (89%) had abnormal cytology, showing cervical intraepithelial neoplasia of grade 1 (CIN1) ( Table I).As a control group, we selected seven age-matched patients that had HPV infection but were negative for UP infection: four of them (57%) had normal cytology whereas three (43%) had abnormal cytology (CIN1).The age-matched control group was selected among the 25 UP negative patients. Excluding the 7 patients mentioned above, forming the control group, of the remaining 18, 12 were HPV negative and with normal cytology, 4 were HPV positive with a normal cytology, and 2 were HPV positive with CIN 1.Sixteen (89%) of the co-infected patients had CIN1 lesions while only 43% of the patients without UP co-infection had CIN1 lesions. We assessed the statistical significance between the two groups with the Fisher's exact test (two-tailed P-value ¼ 0.0324).HPV infection is a definite human carcinogen, but only few of the HPV infected population develop cancer, suggesting that other risk factors may play a promoting role. Other STIs can be significant in the carcinogenic pathway of HPV, increasing the risk of cancer and cervical intraepithelia...

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Impact of human papillomavirus coinfections on the risk of high-grade squamous intraepithelial lesion and cervical cancer

Cited by 40 publications

References 30 publications

Prevalence of sexually transmitted pathogens associated with HPV infection in cervical samples in a Mexican population

Prevalence of sexually transmitted pathogens associated with HPV infection in cervical samples in a Mexican population

High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population

Ureaplasma parvum as a possible enhancer agent of HPV‐induced cervical intraepithelial neoplasia: Preliminary results

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