Impact of ischemic time on post-infarction left ventricular function in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Ng, Sunanto; Ottervanger, Jan Paul; Hof, Arnoud W J van ‘t; Boer, Menko‐Jan de; Reiffers, S.; Dambrink, Jan‐Henk E.; Hoorntje, Jan C.A.; Gosselink, A T Marcel; Suryapranata, Harry

doi:10.1016/j.ijcard.2011.09.082

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Short-and long-term outcomes in patients with acute myocardial infarction (AMI) are closely related to the time of reperfusion (1)(2)(3)(4). The risk of mortality is likely to increase by 7.5% for each 30-minute delay in treatment (2).…”

Section: Introductionmentioning

confidence: 99%

The impact of the Type D Personality pattern on prehospital delay in patients suffering from acute myocardial infarction

Zhang

Pan

et al. 2020

J Thorac Dis

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Background: The Type D Personality (TDP) has been specifically linked to acute myocardial infarction (AMI). However, the impact on prehospital delay of AMI patients is unclear. The aim of this study was to assess the relationship between TDP and pre-hospital delay time (PHT) in a Chinese population. Methods: A total of 256 AMI patients (47 women and 209 men) were taken from the Multicenter Delay in Patients Experiencing AMI in Shanghai (MEDEA FAR-EAST) study. Sociodemographic and psychobehavioral characteristics were assessed by bedside interviews and questionnaires. TDP was evaluated according to the Type D Personality Scale (DS14) subdivided in social inhibition (SI) and negative affectivity (NA). Based on a significant interaction analysis of TDP and sex on PHT, all analyses were stratified by sex.Results: PHT of female patients with TDP were substantially shorter compared to non-TDP female patients (108 vs. 281 min, P=0.029). In male patients, no effect of TDT on PHT was found. Spearman correlation analysis suggests that NA was negatively correlated with PHT (r=−0.358, P=0.014). Further age-adjusted logistic regression analyses showed that female patients with TDP were generally less likely to prehospital delay compared with non-TDP patients (OR =0.28; 95% CI, 0.08-0.98) and had a lower risk of PHT >360 minutes (OR =0.10; 95% CI, 0.01-0.91). However, statistical significance disappeared after adjustment for psychological factors (anxiety, depression, suboptimal wellbeing, cardiac denial and stress event). Conclusions: TDP is associated with less prehospital delay in female patients during AMI-an effect which may be particularly mediated by NA.

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Section: Introductionmentioning

confidence: 99%

The impact of the Type D Personality pattern on prehospital delay in patients suffering from acute myocardial infarction

Zhang

Pan

et al. 2020

J Thorac Dis

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“…Key words: risk factors; prehospital delay; myocardial infarction I n individuals with acute myocardial infarction (AMI), longer ischemic time results in poor short-and long-term outcomes, specifically larger infarct size, higher rate of ischemic cardiomyopathy, and greater mortality. [1][2][3][4][5][6] Older adults are at greater risk of delays in revascularization after experiencing an AMI than younger individuals. [7][8][9][10] Many efforts to improve outcomes after AMI have targeted in-hospital treatment delays ("door-to-balloon time" strategies), but total ischemic time also notably includes the prehospital period from the onset of symptoms to presentation to a healthcare setting.…”

mentioning

confidence: 99%

“…In individuals with acute myocardial infarction (AMI), longer ischemic time results in poor short‐ and long‐term outcomes, specifically larger infarct size, higher rate of ischemic cardiomyopathy, and greater mortality . Older adults are at greater risk of delays in revascularization after experiencing an AMI than younger individuals .…”

mentioning

confidence: 99%

Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study

Ouellet

Geda

Murphy

et al. 2017

J American Geriatrics Society

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Background/Objectives Timely administration of anti-ischemic therapies improves outcomes in patients with acute myocardial infarction (AMI). Prior literature on delays in AMI care has largely focused on in-hospital delay (“door-to-balloon” time). Our objective was to identify factors associated with pre-hospital delay in a contemporary, national cohort of older AMI patients. Design Cross-sectional analysis from SILVER-AMI (ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction), an observational study of older patients hospitalized for AMI. Setting 94 U.S. academic and community hospitals. Participants 2500 patients aged 75 or older hospitalized for AMI. Measurements Pre-hospital delay was defined as symptom duration ≥ 6 hours before hospital presentation and was obtained by patient/caregiver report during AMI hospitalization. Potential predictors of delay from the following domains (demographics, clinical presentation, comorbid conditions, function, and social support) were obtained through in-person assessment during the index hospitalization and medical record abstraction. Results Non-white race, atypical symptoms, and heart failure (HF) were significantly associated with delay (adjusted OR 1.54, p=0.002 for non-white race; adjusted OR 1.41, p=0.001 for atypical symptoms; adjusted OR 1.35, p=0.006 for HF). Conclusion In contrast with younger AMI populations, female sex and diabetes were not associated with delay in this older cohort. However, factors from multiple different domains (non-white race, atypical symptoms, and HF) were significantly associated with delay. These results can be used to tailor future public health efforts to encourage early presentation for older AMI patients.

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“…Our main study revealed that 80% of patients still had inadequate platelet inhibition despite adjunctive antiplatelet therapy and fibrinolytic therapy [8]. Since our patients were pre-treated with clopidogrel, the expected proportion of Reperfusion inhibits ischemic progression and limits infarct size [15,16]. Although fibrinolysis aims to achieve reperfusion, TIMI flow is a surrogate of myocardial recovery and survival [17].…”

Section: Discussionmentioning

confidence: 94%

Effects of Baseline Platelet Reactivity on Thrombolysis in Myocardial Infarction Flow and Ischemic Time in Fibrinolysis-treated ST Elevation Myocardial Infarction Patients

P¹,

Yang²,

Q³

et al. 2018

J Thrombo Cir

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Objective: Thrombolysis in Myocardial Infarction (TIMI) flow in ST-Elevation Myocardial Infarction (STEMI) is a prognostic predictor that is directly influenced by duration of culprit artery occlusion; ischemic time. It is unknown whether platelet reactivity measured by P2Y12 reaction unit (PRU) is affected by ischemic time or predictive of TIMI flow. Our objectives were to examine the effect of baseline PRU on TIMI flow and on ischemic time. Methods: Between May 2014 and August 2016, the study included 144 patients between four sites undergoing percutaneous coronary intervention (PCI) within 24 hours of tenecteplase, aspirin and clopidogrel for STEMI. The VerifyNow ® Assay measured baseline PRU prior to angiography. Ischemic time was defined as the duration between index symptom onset and tenecteplase administration. Kruskal-Wallis H test was conducted because the assumption of normality was violated to test differences in baseline PRU based on TIMI flow and based on time intervals prior to PCI. Results: Median ischemic time was 172 minutes (IQR 115-285). Baseline PRU did not differ based on TIMI flow grade {χ 2 (3)=3.00, p=0.39}. Baseline PRU was not affected based on ischemic time {χ 2 (3)=1.50, p=0.68)}. Conclusion: Platelet reactivity measured by PRU is not associated with TIMI flow or ischemic time. Future research is warranted to examine the association between baseline PRU and prognosis.

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Impact of ischemic time on post-infarction left ventricular function in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Cited by 6 publications

References 28 publications

The impact of the Type D Personality pattern on prehospital delay in patients suffering from acute myocardial infarction

The impact of the Type D Personality pattern on prehospital delay in patients suffering from acute myocardial infarction

Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study

Effects of Baseline Platelet Reactivity on Thrombolysis in Myocardial Infarction Flow and Ischemic Time in Fibrinolysis-treated ST Elevation Myocardial Infarction Patients

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