The objective: to determine groups at high risk of developing tuberculosis (TB) among adult population of Kaluga Oblast.Subjects and Methods: data from Federal Statistical Surveillance Forms no. 8, 33, 12, 36, and 37 for 2015-2021, Rosstat data on the population of Kaluga Oblast. Pearson's chi-square test (χ2) was used for data analysis.Results. Among adult population, 8 groups facing the high risk of developing tuberculosis have been identified: HIV-positive individuals, people exposes to tuberculosis patients with a positive result of sputum testing, drug users, inmates staying in institutions of the Federal Penitentiary Service, individuals not screened for ≥ 2 years, homeless, migrants, and persons with alcohol addiction.According to results of analysis of factors that had a negative impact on the course of respiratory tuberculosis, the highest risk of developing a severe course was registered only in groups at advanced risk of tuberculosis: HIV-positive individuals, drug users, persons with alcohol addiction, homeless, individuals not screened for ≥ 2 years, and people exposes to tuberculosis patients with a positive result of sputum testing.