Impact of lung‐function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes

Lee, Hwa Mu; Zhao, Yanglu; Liu, Michael A.; Yanez, David; Carnethon, Mercedes R.; Barr, R. Graham; Wong, Nathan D.

doi:10.1002/clc.22985

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…High concentration of PAPP-A was also demonstrated to be associated with increased number of miscarriages and fetal loss ( 24 , 25 ). Studies have also reported that women who experienced pregnancy loss were at higher risk for cardiovascular diseases and diabetes ( 10 , 14 , 26 , 27 ), which have been associated with reduced lung function ( 28 ). Moreover, decreased lung function have been linked to increased levels of markers for inflammation ( 29 ), and increasing evidence indicates that chronic inflammatory and immune responses play key roles in the pathogenesis of different forms of lung conditions, including COPD ( 15 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Association between pregnancy and pregnancy loss with COPD in Chinese women: The China Kadoorie Biobank study

Hee

Oswald

Gongye

et al. 2022

Front. Public Health

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BackgroundChronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by airflow blockage. Pregnancy and pregnancy loss may be related to an elevated risk of COPD, although studies have yet to report on this association. Hence, this study aims to investigate the association between pregnancy and pregnancy loss with the risk of COPD among Chinese women.MethodsData on 302,510 female participants from the China Kadoorie Biobank were utilized for this study. Multivariable logistic regression, stratified by sociodemographic and lifestyle factors, was employed to obtain the odds ratio (ORs) and 95% confidence intervals (CIs) for the association between pregnancy and pregnancy loss with COPD.ResultsPregnancy loss was significantly associated with increased risk of COPD (OR 1.19, 95% CI 1.13–1.25), specifically, spontaneous (OR 1.19, 95% CI 1.11–1.29) and induced abortion (OR 1.18, 95% CI 1.12–1.25). Stillbirth, however, was not significantly associated with the risk of COPD (OR 1.09, 95% CI 0.99–1.20). Increasing number of pregnancy losses was associated with increasing risk of COPD (one pregnancy loss: OR 1.14, 95% CI 1.07–1.21, two or more pregnancy loss: OR 1.25, 95% CI 1.17–1.32, and each additional pregnancy loss: OR 1.06, 95% CI 1.03–1.09). A single pregnancy was significantly associated with reduced risk of COPD (OR 0.75, 95% CI 0.59–0.97), although each additional pregnancy was significantly associated with increased risk of COPD (OR 1.03, 95% CI 1.01–1.04).ConclusionPregnancy loss, in particular, spontaneous and induced abortions are associated with increased risk of COPD among Chinese women. A single pregnancy, however, demonstrated protective effects.

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Section: Discussionmentioning

confidence: 99%

Association between pregnancy and pregnancy loss with COPD in Chinese women: The China Kadoorie Biobank study

Hee

Oswald

Gongye

et al. 2022

Front. Public Health

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“…As described, the MS defines the presence of three or more components, which are related to each other for the development of various pathologies especially cardiovascular and hepatic (Katsiki, Perez-Martinez, Anagnostis, Mikhailidis, & Karagiannis, 2018;Lee et al al., 2018). The component with the highest prevalence found in the evaluated workers was the abdominal adipose tissue, in this sense, the literature states that the tissue participates in the release of different substances favoring the appearance of a proinflammatory state, insulin resistance or endothelial damage.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome and Its Components in Workers of a High-Level Educational Institution, Cartagena-Colombia

Castaño¹,

Avila²,

Tapia³

et al. 2018

GJHS

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To determine the prevalence of metabolic syndrome, components and their relationship in workers of a higher education institution of Cartagena-Colombia. An analytical cross-sectional study was carried out, with a probabilistic sample of 162 workers in a higher education institution. Sociodemographic data were recorded, physical examination including abdominal circumference, blood pressure, height, weight, as well as clinical tests of lipid laboratory (total cholesterol, HDL cholesterol and triglycerides) and fasting glycemia determined by colorimetric and enzymatic methods. The parameters established by the American Heart Association-AHA were used to identify metabolic syndrome. A prevalence of metabolic syndrome of 11.1% was estimated. The most frequent components among individuals with metabolic syndrome were: increase in abdominal circumference (83.3%), hypertriglyceridemia (66.7%) and low levels of HDL-c (50.0%). The elevation of the abdominal perimeter was the most frequent component. No statistical evidence of association between any of the components of the syndrome was found. These evidences suggest to improve the life habits of the workers evaluated, in terms of their nutrition and physical activity.

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“…Moreover, since the Framingham study found an inverse relationship between forced vital capacity (FVC) and cardiovascular diseases in 1983 [ 8 ], several studies consistently showed an association between hypertension and impaired pulmonary function [ 9 , 10 ]. Some studies even revealed that the coexistence of hypertension and reduced lung function was associated with a higher mortality rate [ 11 , 12 ]. Although the pathologic mechanism is not entirely investigated, chronic systemic and pulmonary inflammation is being regarded as the main mechanism.…”

Section: Introductionmentioning

confidence: 99%

Hypertension Is Associated with Increased Risk of Diabetic Lung

Lee

Kwon

Lee

et al. 2020

IJERPH

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Lung function is often impaired in diabetic patients, especially in a restrictive pattern, which has recently been described as the diabetic lung. Since hypertension (HTN) is common in diabetic patients, our study investigated whether HTN acts as an aggravating factor in diabetic lung. Within the cross-sectional study from the 6th Korean National Health and Nutrition Examination Survey (KNHANES), fasting plasma glucose (FPG), blood pressure (BP), pulmonary function, and laboratory data were examined in 4644 subjects aged between 40 and 79 years. A multivariate regression model was used to investigate the relationship between BP, FPG, and pulmonary function. Lung function was significantly reduced in the HTN (p = 0.001), impaired fasting glucose (IFG) (p < 0.001), and diabetes mellitus (DM) (p < 0.001) groups. Next, a multivariate logistic regression model was used to derive the odds ratio (OR) of reduced lung function based on the presence of IFG, DM, and HTN. The OR of reduced forced vital capacity (FVCp < 80%) was 3.30 (p < 0.001) in the HTN-DM group and 2.30 (p < 0.001) in the normal BP-DM group, when compared with the normal BP-normal FPG group. The combination of HTN and DM had the strongest negative effect on FVC. The results presented in this study indicate that diabetes and hypertension have a synergistic association with impaired lung function.

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Impact of lung‐function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes

Abstract: FEV and FVC are inversely related to CVD in older adults with and without MetS, but not DM (except for CHF); however, their value in incremental risk prediction beyond standard risk factors is limited mainly to metabolically healthier persons.

Cited by 6 publications

References 34 publications

Association between pregnancy and pregnancy loss with COPD in Chinese women: The China Kadoorie Biobank study

Association between pregnancy and pregnancy loss with COPD in Chinese women: The China Kadoorie Biobank study

Prevalence of Metabolic Syndrome and Its Components in Workers of a High-Level Educational Institution, Cartagena-Colombia

Hypertension Is Associated with Increased Risk of Diabetic Lung

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