Impact of nucleic acid testing for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus on the safety of blood supply in Italy: a 6‐year survey

Velati, Claudio; Romanò, Luisa; Fomiatti, L.; Baruffi, Lorella; Zanetti, Alessandro

doi:10.1111/j.1537-2995.2008.01813.x

Cited by 83 publications

(79 citation statements)

References 40 publications

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“…This is in the range of prevalence of OBI estimated in Italy in previous studies (0.013-0.006%) (Dettori et al, 2009;Velati et al, 2008) and in other European Countries, such as Greece (0.0002%) and Poland (0.084%) (Brojer et al, 2006;Katsoulidou et al, 2009).…”

Section: Discussionsupporting

confidence: 62%

“…The prevalence of OBI in blood donors has been reported in some European Countries such as Poland, Germany, and France (Brojer et al, 2006;Katsoulidou et al, 2009;Levast et al, 2010), while in others, such Italy, recent data are limited (Velati et al, 2008;Dettori et al, 2009). This information is critical in order to set up optimized transfusion services.…”

Section: Introductionmentioning

confidence: 99%

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Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

et al. 2012

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

et al. 2012

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“…Birçok ülkede olduğu gibi ülkemizde de transfüzyonla bulaşan infeksiyonlardan korunmada önemli gelişmeler olmuştur. Hepatit B aşısının yaygınlaşması, kan vericilerin ayrıntılı sorgulanması, seçilen vericilerden hazırlanan kan ürünlerinin ileri moleküler yöntemlerle taranması bu geliş-mede önemli rol oynamıştır (15,21,22) . HBV infeksiyonu gelişiminde perinatal bulaş da önemli bir yer tutmaktadır.…”

Section: Introductionunclassified

Frequency of Hepatitis B, Hepatitis C and HIV (Human Immunodeficiency Virus) in Thalassemia Major Patients Having Multiple Transfusion

Şahin¹,

Yıldırmak²,

Bulut³

2018

Ankem Derg

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ÖZET Talasemi majörlü hastalar yaşamları boyunca çok sayıda kan transfüzyonuna ihtiyaç duyarlar bu nedenle transfüzyonla bulaşan hastalıklar açısından risk altındadırlar. Bu çalışma, çocuk hematoloji kliniğimizde takip edilen talasemi majörlü hastalarda transfüzyon ile bulaşan hepatit B (HBV), hepatit C (HCV) ve insan immün yetmezlik virüsü (HIV) infeksiyonlarının SUMMARY Frequency of Hepatitis B, Hepatitis C and HIV (Human Immunodeficiency Virus) in Thalassemia Major Patients Having Multiple Transfusion Thalassemia major patients need many blood transfusions throughout their lives. Hence, they are at risk for transfusion-transmitted diseases. This study was conducted to determine the frequency of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) infections in thalassemia major patients in our pediatric hematology clinic and to investigate the clinical and demographic characteristics of positive patients.In

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“…With the implementation of enhanced sensitive serological tests and nucleic acid tests (NAT), the risk has reduced. In developed countries, it was as low as below 1:1 million for HCV in the last decade (2)(3)(4). Therefore, blood transfusion has currently not been considered as a major transmission route.…”

Section: Introductionmentioning

confidence: 99%

Diverse Genotypes of Hepatitis C Virus in Voluntary Blood Donors in Shanghai, China

Wang

Gong

et al. 2017

Hepat Mon

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Background: Prevalence of hepatitis C virus (HCV) in voluntary blood donors (VBD) in China has decreased progressively. However, it was still higher than those in developed countries and some developing countries. Methods: A total of 38952 VBD in Shanghai, China, were recruited in the study. The donated blood specimens were examined for anti-HCV antibody by ELISA. Hepatitis B virus DNA, HCV RNA, or HIV-1 RNA was subsequently tested by nucleic acid test (NAT) in the specimens negative for anti-HCV. A 377-nt partial sequence in HCV NS5B region was amplified in the specimens positive for anti-HCV or positive by NAT. To conduct a phylogenetic analysis, 179 sequences most phylogenetically identical to the VBD strains with BLAST search were retrieved in the GenBank and thirty nine 377-nt partial sequences isolated contemporaneously in local intravenous drug users (IDU) were included. Results: Overall prevalence of anti-HCV antibody in VBD was 0.46% (179/38952). Varying along demographics, the prevalence was higher in those aged 18-30 years and first donors. A total of thirty seven 377-nt partial sequences were amplified in the specimens positive for anti-HCV, whereas they were not seen in those negative for anti-HCV while positive by NAT. HCV genotype 1b was most predominant in VBD, followed by 2a, 3a, 1a, 3b, 6n, and 6a; in contrast, genotypes 3a and 3b were dominant in IDU. In genotypes 3a, 3b, 6a, and 6n, VBD and IDU strains shared high sequence identities and clustered together. In genotype 1b, VBD strains were phylogenetically identical to the sequences isolated across China, of which some were clustered more closely with IDU strains than the retrieved sequences. Conclusions: HCV prevalence in VBD in Shanghai remained low. However, there were diverse genotypes of HCV that were identified in VBD. HCV transmission from high-risk population to general population is likely to occur.

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Impact of nucleic acid testing for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus on the safety of blood supply in Italy: a 6‐year survey

Cited by 83 publications

References 40 publications

Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Frequency of Hepatitis B, Hepatitis C and HIV (Human Immunodeficiency Virus) in Thalassemia Major Patients Having Multiple Transfusion

Diverse Genotypes of Hepatitis C Virus in Voluntary Blood Donors in Shanghai, China

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