Impact of occupational vibration on molecular and cell level of human body

Kiryakov, V. A.; Pavlovskaya, N.A.; Lapko, Inna V.; Bogatyreva, Inessa A.; Antoshina, L I; Oshkoderov, O A

doi:10.31089/1026-9428-2018-9-34-43

Cited by 20 publications

(3 citation statements)

References 4 publications

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“…В качестве ультраструктурных мишеней для воздействия вибрации выступают все органеллы и клетки, но наиболее чувствительны мембраны и митохондрии, нарушение функции которых проявляется в виде вибрационно-опосредованных цитопатий, мембранопатий и дисфункции митохондрий, ведущих к развитию хронической гипоксии [7,8]. Фактор гипоксии играет ключевую роль в патогенетической, морфологической, электрофизиологической концепции «ремоделирования миокарда» [9,10] и сопровождается модификацией метаболизма и структуры кардиомиоцитов [11].…”

Section: патофизиологические предпосылки ремоделирования миокарда на ...unclassified

“…Помимо прямого повреждающего действия и опосредованного, через активизацию прооксидантной системы в основе вибрационно-опосредованных изменений лежат нейрогуморальные [8,[16][17][18][19] и нейрорефлекторные нарушения [20,21], усугубляющие гипоксию тканей [7]. У пациентов с ВБ наблюдаются изменения кальциевого гомеостаза, который находится под контролем глюкокортикоидов, соматотропина, кальцийрегулирующих гормонов (паратгормон, кальцитонин) и витамина D [22].…”

Section: патофизиологические предпосылки ремоделирования миокарда на ...unclassified

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Mechanisms of vibration-induced structural myocardial remodeling

Vorobieva,

Levchenkova,

Lenskaya

et al. 2024

Rev Clin Pharm Drug Ther

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The review presents literature data analysis devoted to the study of structural changes in the heart in patients with vibration disease, identified by echocardiographic methods in the form of concentric remodeling of the left ventricle chambers and disturbance of its diastolic function, a decrease in the intensity of the heart structure work compared to healthy ones in 1.2 times (p0.05). The changes in morphometric and bioenergetic parameters of cardiomyocytes against the background of various experimental vibration modes (7 and 56 sessions with a frequency of 8 Hz) confirms the violation of the ideal relationship between the spatial configuration of the heart cavities, the ability to contract and the energy supply potential. The loss of cardiac myofibrils symbolizes the convertion of myocardial hypertrophy to the decompensation stage and the increase in degenerative (dystrophic) signs, in particular the loss of sarcomeres of cardiomyocytes. To realize the processes of pathological structural (morphological) and energy restructuring of tissue under the influence of vibration-mediated hemodynamic and ischemic factors, it is necessary to involve in the process numerous mediators that regulate metabolism, proliferation, growth and survival of cells, such as STIM (stromal interaction molecule), SERCA (calcium ATPase of the endo(sarco)plasmic reticulum), IP3R (inositol-1,4,5-triphosphate receptor), Orai (protein that forms CRAC channels), TRPC (transient receptor potential canonical), etc. As one of the most important link of structural cardiac remodeling is performed by the degradation system of the extracellular matrix, including matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), which regulate the rate of mRNA synthesis on the DNA matrix by binding to specific DNA regions that control cardiac nutrition and plasticity. A lot of analyzed facts make it possible to explain some patterns of the development of cardiac remodeling in patients with vibration disease and to determine the direction of pathogenetically based approaches to therapy, taking into account not only the vibration-protective effect of drugs, but also their ability to inhibit and regress myocardial remodeling.

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Section: патофизиологические предпосылки ремоделирования миокарда на ...unclassified

Mechanisms of vibration-induced structural myocardial remodeling

Vorobieva,

Levchenkova,

Lenskaya

et al. 2024

Rev Clin Pharm Drug Ther

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“…The effect of vibration on a person depends both on the physical characteristics of the oscillatory process and on the duration of body contact with vibrating surfaces [14]. It can lead to persistent adverse changes in physiological and biochemical functions in the body and even be accompanied by morphological changes in the body [1,16].…”

Section: Relevancementioning

confidence: 99%

Multiple Influence of Vibration on Biochemical Brain Indicators

Elbek M. Mirjuraev, Askar U. Sadikov

2023

tjjpt

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Dysfunction of the nervous system is one of the main manifestations caused by vibration. With repeated exposure to vibration, significant changes in the activity of enzymes and the content of the studied substrates in the brain tissue of experimental animals are observed. The observed changes in the activity of enzymes and the content of the studied substrates of brain tissue and the associated disturbances in the basic biochemical metabolic processes may be the direct cause of serious disorders of the functions of the nervous system. According to research results, it was revealed that exposure to general vibration leads to disturbances in the process of transamination of alanine-, aspartic-amino acids, cholinesterase, the activity of enzymes of the tricarboxylic acid cycle (GDH, SDH and MDH), alkaline phosphatase, ribonuclease and lactate dehydrogenase, as well as the content of total protein, serotonin, histamine and acetylcholine in the brain of experimental animals.

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