Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants

Abstract

BackgroundFlavonoids and other polyphenols play a protective role in liver diseases and possess a high antioxidant capacity.ObjectiveTo compare and evaluate the antioxidant and hepatotoprotective activities of 4 deserts plants, Fagonia indica Burm. f., Calotropis procera R.Br., Zygophylum hamiense Schweinf. and Salsola imbricata Forssk. in correlation to their composition especially their phenolic content.MethodsThe influence of extracting solvent on total phenolic and flavonoidal contents was assessed spectrophotometrically. The flavonoid and other polyphenolic components of the methanol extracts were analyzed by RP-HPLC. DPPH radical scavenging potential of the different extracts was estimated. The hepatoprotective and antioxidant activities of the extracts against CCl4-induced hepatotoxicity in mice were evaluated.ResultsThe flavonol quercitrin and rosmarinic acid were major in the F. indica, C. procera and S. imbricata samples, while rutin prevailed in that of Z. hamiense. The ethanolic and methanolic extracts showed noticeable DPPH radical-scavenging activity as compared to ascorbic acid. Assessment of liver enzymes revealed that oral administration of the extracts did not show any evidence of hepatotoxicity. Moreover, protection against CCl4-induced liver damage was evident upon administration of three plants extracts namely, F. indica, C. procera and S. imbricata.ConclusionOverall, hepatotoxicity induced by CCl4 was effectively prevented by the three plants extracts through scavenging of free radicals and by boosting the antioxidant capacity of the liver. The protective effect of the plants could be attributed to their high quercitrin and rosmarinic acid contents.

Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat

“…This reversal of the enzyme levels by the extract is probably because of their membrane stabilizing activity which prevents leakage of intracellular enzymes. This is in accordance with the generally established view that serum levels of transaminases restored to normal with the regeneration of liver cells and healing of liver parenchyma [19, 50]. …”

“…Pareek et al [18] investigated the i n vitro and in vivo antioxidant activity of F. schweinfurthi through DPPH, ABTS radicals and hydrogen peroxide methods and hepatoprotective potential against CCl 4 induced toxicity in HepG2 cells and in rat. Hepatoprotective activity of F. indica has also been reported in earlier studies [19, 20]. Antitumor potential of F. cretica has been reported in different studies [21, 22].…”

“…Serum ALP, total protein and total bilirubin are also linked to the liver cell function. The elevation in serum ALP is because of increased synthesis, in presence of increasing biliary pressure [19, 20, 49]. Acetaminophen administration caused a significant rise of enzyme levels including AST, ALT, ALP, total bilirubin and decline in total protein in comparison to control.…”

A Comprehensive Review on Genus Zygophyllum

“…Alzheimer's disease and brain diseases with deficiency in cholinergic function Z. coccienium 9,26 Egypt, Kuwait, Saudi Arabia Gout, Rheumatic pain and hypertension Z. cornutum 10 Algeria Diabetes, hypertension and dermatitis Z. decumbens 27 Egypt, Syria, Sudan Hypotension, fever and GIT spasm Z. dumosum 23,28,29 Egypt Rheumatism, gout, asthma and hypertension Z. fabago 19 China, Spain, Turkey, Iran, Kazakhstan and Iraq Fungal infections, Parasitic worms, constipation, product cough, inflammation, and asthma Z. gaetulum 11 Morocco GIT spasms, hyperglycemia accompanying diabetes and eczema Z. geslini 12 Algeria Hyperglycemia accompanying diabetes Z. hamiense 30 Deserts of Asia and Africa As hepato-protective Z. macropodum 31 China Pain and inflammation Z. melongena 20 Mongolia Snake poisoning (as it inhibits of the snake venom phosphodiesterase)…”

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

“…Investigations revealed that leaf extracts also contain saponins, tannins, triterpenoids, steroids, glycosides, and flavonoids. The antioxidant and hepatoprotective potentials of flavonoids (Shehab, Abu-Gharbieh, & Bayoumi, 2015) and triterpenoids are well identified. On the other hand, SOD and glutathione peroxidase were increased in fat suspension steatohepatitis model of rat.…”