Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer

Abstract

Purpose. Regular physical activity (PA) can affect oxidative stress, known to be involved in carcinogenesis. The objective of this study was to evaluate the associations between a six-month PA intervention and oxidative stress biomarkers, PA, and clinical outcomes in patients with metastatic breast cancer. Methods. Forty-nine newly diagnosed patients with metastatic breast cancer were recruited for a single-arm, unsupervised, and personalized six-month walking intervention with activity tracker. PA level and PA fitness, plasma concentrations of DNA oxidation (8OhdG), lipid peroxidation (MDA), and protein oxidation (AOPP), plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase, plasma and leucocyte activities of myeloperoxidase (MPO) and NADPH oxidase (NOX), and clinical markers of tumor progression (RECIST criteria) were measured at baseline and after the six-month intervention. Results. GPX activity (+17%) and MDA (+9%) significantly increased between baseline and the end of the intervention. Changes in PA level and fitness were significantly positively correlated with changes in plasma GPX and significantly negatively with changes in NOX in the leucocytes. Plasma MDA was significantly higher (+20%) whereas plasma AOPP was lower (-46%) for patients with tumor progression or that died during the six months as compared to patients without progression. Conclusion. A six-month PA intervention may be potentially beneficial in metastatic breast cancer patients for enhancing antioxidant enzyme activity and decreasing prooxidant enzyme activity. Moreover, AOPP and MDA could also be favorable and unfavorable biomarkers, respectively, since they are associated with disease progression and fitness level in this population. This trial is registered with NCT number: NCT03148886.

Radioprotective effect of X‐ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factors

“…It is reported that the generation of MDA can aggravate the damage of the cell membrane and also reflect antioxidant capacity 38,39 . Change in inflammatory cytokines may be a downstream process of increased MDA production in the normal tissues of the CONV group.…”

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

“…These data are intriguing in the context of the clinical management of BC patients since the widely noted role of inflammation in the complex process underpinning oncogenesis and cancer growth promotion ( Mahadevan and Zanetti, 2011 ; Koelwyn et al, 2015 ). In addition, strong evidence supported the role of physical exercise in increasing the overall survival of BC patients, probably due to its effects on oxidative stress and inflammation ( Saarto et al, 2012 ; Winters-Stone et al, 2013 ; Wennerberg et al, 2020 ; Delrieu et al, 2021 ; Vehmanen et al, 2021 ; Longobucco et al, 2022 ). Therefore, these biomarker modifications might be the basis for a more precise exercise prescription aiming at reducing systemic inflammation in BC survivors in order to reduce tumor growth or risk of recurrence.…”

Plasma Levels of Acyl-Carnitines and Carboxylic Acids Correlate With Cardiovascular and Kidney Function in Subjects With Sickle Cell Trait

“…Plasma antioxidant activity (plasma superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX)), and markers of oxidative stress damage (advanced oxidation protein products (AOPP), and malondialdehyde) were determined as previously described ( Delrieu et al, 2021 ) (Delrieu et al, Oxidative Medicine and Cellular Longevity 2021).…”