Impact of simulation and reference catalogues on the evaluation of taxonomic profiling pipelines
Vadim Puller,
Florian Plaza Oñate,
Edi Prifti
et al.
Abstract:Microbiome profiling tools rely on reference catalogues, which signifi-cantly affect their performance. Comparing them is however challenging, mainly due to differences in their native catalogues. In this study, we present a novel standardized benchmarking framework that makes such comparisons more accurate. Specifically, we conducted three realistic sim-ulations of gut microbiome samples, each based on a specific taxonomic profiler, and used two taxonomic references to project their results: the Genome Taxono… Show more
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