Impact of smoking status and cumulative smoking exposure on tumor recurrence of non-muscle-invasive bladder cancer

Li, Hao Min; Azhati, Baihetiya; Rexiati, Mulati; Wang, Wen Guang; Li, Xiao Dong; Liu, Qiang; Wang, Yujie

doi:10.1007/s11255-016-1441-6

Cited by 19 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A higher BMI is associated with hormonal changes and systemic inflammatory response increasing the risk of recurrence and progression of NMIBC [12]. Although the current smoking status was shown to be associated with recurrence, this was not the case in our study [13].…”

Section: Discussioncontrasting

confidence: 75%

Post-Bacille Calmette–Guerin surveillance for non-muscle invasive bladder cancer: do random biopsies offer an advantage?

et al. 2021

View full text Add to dashboard Cite

Background The optimal surveillance method for recurrence of non-muscle invasive bladder cancer (NMIBC) after intravesical BCG treatment is unknown. The aim of this study is to assess the difference between two surveillance methods: cystoscopy with bladder biopsies and office-based flexible cystoscopy in detecting NMIBC recurrence and time to recurrence. Methods Charts of patients who underwent transurethral resection of bladder tumor with subsequent intravesical Bacillus Calmette–Guerin (BCG) treatment were reviewed between January 2015 and December 2018. Baseline demographics and oncological parameters were compared between the two methods of surveillance. Then, the role of the surveillance method for NMIBC recurrence and time to recurrence were evaluated in backward logistic regression and hazard ratios estimated in Cox regression models, respectively. Results Fifty-one patients (50.5%) underwent office-based flexible cystoscopy and 50 patients (49.5%) had bladder biopsies. The patients undergoing either surveillance methods were comparable for baseline demographic and oncological parameter. The predictors of recurrence and earlier BCG relapse were increased body mass index, the presence of multifocal tumors, the presence of concurrent carcinoma in situ, and tumor size at presentation. Bladder cancer recurrence was mostly affected by multifocality of the disease [OR 3.61 95%CI (1.17–11.15)] and the presence of concomitant carcinoma in situ [4.35 (1.29–14.68)]. Yet, the surveillance method neither predicted a higher recurrence yield nor earlier diagnosis. Conclusion In our cohort, there is neither difference in recurrence yield nor earlier diagnosis of recurrence between office-based flexible cystoscopy and bladder biopsies. Larger prospective studies are needed to assess the generalizability of these findings.

show abstract

Section: Discussioncontrasting

confidence: 75%

Post-Bacille Calmette–Guerin surveillance for non-muscle invasive bladder cancer: do random biopsies offer an advantage?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Another recent study not included in the aforementioned meta-analysis shows similar HRs (HR 1.49, 95% CI 0.95–2.33) for current smokers at diagnosis [ 8 ]. However, when including this study and our study (data from continuing smokers) in the meta-analysis, the pooled HR barely changes from 1.27 (95% CI 1.09–1.46) to 1.26 (95% CI 1.12–1.40) [ 10 ], indicating a significantly increased risk of recurrence for current smokers at diagnosis compared to never smokers.…”

Section: Discussionmentioning

confidence: 94%

The association between smoking cessation before and after diagnosis and non-muscle-invasive bladder cancer recurrence: a prospective cohort study

Osch

Jochems

Reulen

et al. 2018

Cancer Causes Control

View full text Add to dashboard Cite

BackgroundSmoking is a major risk factor for bladder cancer, but the relationship between smoking cessation after initial treatment and bladder cancer recurrence has been investigated less frequently and not prospectively yet.Methods722 non-muscle-invasive bladder cancer (NMIBC) patients (pTa, pT1, and CIS) from the prospective Bladder Cancer Prognosis Programme (BCPP) cohort, selected in the UK between 2005 and 2011, provided complete data on smoking behavior before and up to 5 years after diagnosis. The impact of smoking behavior on NMIBC recurrence was explored by multivariable Cox regression models investigating time-to-first NMIBC recurrence.ResultsOver a median follow-up period of 4.21 years, 403 pathologically confirmed NMIBC recurrences occurred in 210 patients. Only 25 current smokers at diagnosis quit smoking (14%) during follow-up and smoking cessation after diagnosis did not decrease risk of recurrence compared to continuing smokers (p = 0.352).ConclusionsAlthough quitting smoking after diagnosis might reduce the risk of recurrence based on retrospective evidence, this is not confirmed in this prospective study because the number of NMIBC patients quitting smoking before their first recurrence was too low. Nevertheless, this indicates an important role for urologists and other health care professionals in promoting smoking cessation in NMIBC.

show abstract

“…Кроме того, курение влияет на прогноз РМП. Нынешние и бывшие курильщики с диагнозом МНИРМП демонстрируют более высокие показатели рецидива и прогрессирования, чем никогда не курившие, возможно, из-за общего кумулятивного воздействия табака [48][49][50], и в 4 и 3 раза соответственно чаще умирают от РМП, чем никогда не курившие [39]. У курильщиков существенно выше показатели осложнений, связанных с лечением, а также в 1,4 раза повышен риск специфической смертности от РМП [51].…”

Section: Urologyunclassified

Bladder cancer: the importance of modifiable risk factors

Солодкий¹,

Pavlov²,

Dzidzariya³

et al. 2020

Russian Medical Review

View full text Add to dashboard Cite

Рак мочевого пузыря (РМП) входит в число пяти самых распространенных видов злокачественных новообразований в мире, его лечение является одним из самых дорогостоящих ввиду высокой частоты рецидивов РМП. Курение сигарет и ионизирующая радиация являются хорошо известными факторами риска развития РМП. Однако роль модифицируемых факторов (особенности образа жизни, такие как диета и физическая активность) в развитии РМП изучена недостаточно. В данном обзоре авторами подробно рассмотрены результаты исследований, посвященных значению питьевого режима, питания, физической активности и курения в отношении заболеваемости РМП. Хотя первичная профилактическая борьба с курением и пропаганда здорового образа жизни проводятся на государственном уровне, имеющиеся данные свидетельствуют о потенциально высоких возможностях вторичной профилактики путем систематического включения в клиническую практику уролога рекомендаций по отказу от курения как компонента лечения РМП, имеющего прямое влияние на результаты лечения. Повышенное внимание к этому компоненту консультирования пациентов может принести пользу с точки зрения не только исходов лечения РМП, но и общего состояния здоровья пациента.

show abstract

Impact of smoking status and cumulative smoking exposure on tumor recurrence of non-muscle-invasive bladder cancer

Cited by 19 publications

References 30 publications

Post-Bacille Calmette–Guerin surveillance for non-muscle invasive bladder cancer: do random biopsies offer an advantage?

Post-Bacille Calmette–Guerin surveillance for non-muscle invasive bladder cancer: do random biopsies offer an advantage?

The association between smoking cessation before and after diagnosis and non-muscle-invasive bladder cancer recurrence: a prospective cohort study

Bladder cancer: the importance of modifiable risk factors

Contact Info

Product

Resources

About