2019
DOI: 10.1093/ajcp/aqz012
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Impact of the 2018 ASCO/CAP HER2 Guideline Focused Update

Abstract: Objectives The 2018 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) human epidermal growth factor receptor 2 (HER2) guideline focused update revises the HER2 scoring criteria. We evaluated the impact on HER2 rates in breast carcinoma diagnosed at our center. Methods In a retrospective series of breast core biopsies with invasive carcinoma diagnosed between 2014 and 2017 (n = 1,350), HER2 stat… Show more

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Cited by 38 publications
(23 citation statements)
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“…Many other laboratories have published their experiences with ASCO/CAP 2018 and have shown a reduction in the HER2 FISH-positive rate. 5,6,[8][9][10][11][12] Our study supports these findings and provides additional data on the value of repeat IHC testing aided by digital image analysis in a high-volume reference laboratory environment.…”
Section: Discussionsupporting
confidence: 80%
“…Many other laboratories have published their experiences with ASCO/CAP 2018 and have shown a reduction in the HER2 FISH-positive rate. 5,6,[8][9][10][11][12] Our study supports these findings and provides additional data on the value of repeat IHC testing aided by digital image analysis in a high-volume reference laboratory environment.…”
Section: Discussionsupporting
confidence: 80%
“…Our findings were consistent with the results of the previous studies. Gordian-Arroyo et al [ 18 ] evaluated the impact of the 2018 ASCO/CAP guidelines on breast core biopsies, and identified that 6% of tumors were redistributed mainly to the negative group. Other previous studies also reported that the number of cases in the negative group was significantly increased by applying the 2018 criteria (range 8.2%–10.4%) [ 11 19 20 ].…”
Section: Discussionmentioning
confidence: 99%
“…46,47 Quantitative image analysis system can reduce the laboratory variability of slide scores among pathologists, which is important in routine microscopy. 48…”
Section: Her2 Testing Techniquesmentioning
confidence: 99%