Impact of Thin-Section Computed Tomography-Determined Combined Pulmonary Fibrosis and Emphysema on Outcomes Among Patients With Resected Lung Cancer

Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung

“…Lung cancer patients with comorbid ILD have been found to have worse survival than patients without ILD (19,24,25). Sato and colleagues (26) analyzed the surgical outcomes of patients with NSCLC and ILDs who were in a nation-wide database and found that the 5-year OS of patients with stage IA NSCLC and restrictive ventilatory impairment was, surprisingly, as poor as 20%.…”

“…Patient characteristics (N=222) are shown in Table 1. The mean diameters of tumors and areas of consolidation were 15.4 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and 15.3 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] mm, respectively. The consolidation/tumor ratios ranged from 55.6% to 100%, and 218 (98.2%) of all the tumors appeared as pure solid nodules.…”

“…The characteristics of these patients are shown in Table 3. The mean tumor diameter was 15.5 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] mm. The 5-year OS and RFS were 77.5% and 69.8%, respectively.…”

“…ILDs have also been found to be associated with an increased risk of lung cancer (17,18). The prevalence of lung SqCC is increased in patients with ILDs (19,20). Therefore, patients with lung SqCC are more likely to have comorbid pulmonary diseases and impaired pulmonary function.…”

Clinical characteristics and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema: a systematic review and meta-analysis of 13 studies

“…Lung cancer in patients with CPFE was most common in elderly heavy smokers with a male predominance (9). In three previous studies of lung cancer patients with CPFE adenocarcinoma was the most common type of cancer, followed by squamous cell carcinoma (10)(11)(12). However, other studies had shown that squamous cell carcinoma was the most common type of cancer (13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”