Impact of uterine contractility on quality of life of women undergoing uterine fibroid embolization

Fornazari, Vinícius Adami Vayego; Salazar, Gloria M.; Vayego, Stela Adami; Nunes, Thiago Franchi; Gonçalves, Belarmino; Szejnfeld, Jacob; Bonduki, Cláudio Emílio; Goldman, Suzan Menasce; Szejnfeld, Dênis

doi:10.1186/s42155-019-0080-2

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…This is confirmed by our findings that the content of sex hormones in the local bloodstream has a reliable relationship with the location of the myomatous node. The ability of myoma to change uterine contractility is described, which may interfere with the interaction of sperm and ova or embryo migration [1,12]. Large intramural fibroids interfere with the growth of the pregnant uterus and lead to asymmetric deformations with an increase in the contractility of healthy muscles [13].…”

Section: Discussionmentioning

confidence: 99%

Uterine Fibroids Impact on Fertility and Pregnancy Outcome

Doroha

Iarots'kyĭ

Iarotska

et al. 2020

EUREKA: Health Sciences

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The clinical confirmation of the relationship between uterine leiomyoma and female infertility is of interest to scholars. The aim of our research was to study obstetric history and the level of sex hormones in women of reproductive age with leiomyoma. Materials and methods. The main group consisted of 90 women of reproductive age with uterine leiomyoma, the control group - 45 healthy women. Gynaecological and obstetric history, hormone content in peripheral blood and pelvic vessels (estradiol, progesterone) were analysed. Statistical processing of clinical material was performed using Microsoft Excel, Statistica 7.0, and Statistica 8.0 for Windows. Results. The frequency of infertility in the surveyed women with LM was 18.9 %. One in three patients in the main group (33.3 %) did not give birth, which was statistically different from the healthy women group. In this case, 25.6 % of women in the main group did not use any methods of contraception. It was found that 51.11 % of patients with LM had threatened miscarriage in their history, 37.5 % – complicated delivery. Pathological changes in the concentrations of estradiol and progesterone in the preferential blood and blood vessels of women with fibroids have been identified. We have found that the content of sex hormones in the local bloodstream has a reliable relationship with the location of the myomatous node. Conclusion. The obtained results may indicate that leiomyoma contributes to the reduction of fertility. This is evidenced by the fact that women with LM are more likely to have the risk of miscarriage, complicated delivery and delivery by caesarean section, including complicated one. The findings have made a significant contribution to the further development of effective strategies for the prevention and treatment of infertility in women with fibrotic uterine lesions.

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Section: Discussionmentioning

confidence: 99%

Uterine Fibroids Impact on Fertility and Pregnancy Outcome

Doroha

Iarots'kyĭ

Iarotska

et al. 2020

EUREKA: Health Sciences

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“…The sums of the subscale scores were converted into a transformed score for symptom severity and HRQL ranging from 1 to 100. Consequently, a high score on the Symptom Severity Scale indicates greater symptoms, whereas a high score for HRQL and its subscales indicates a better quality of life 24 – 26 . Assessment with UFS-QOL was performed at baseline prior to the intervention and within the first post-ablation week, after 6 weeks and 3 months followed by 3-month time intervals.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, multiple adjacent lesions on bordering layers produce linear and discoidal necrosis patches, allowing the entire tumor area to be ablated as a volume unit. www.nature.com/scientificreports/ ter quality of life [24][25][26] . Assessment with UFS-QOL was performed at baseline prior to the intervention and within the first post-ablation week, after 6 weeks and 3 months followed by 3-month time intervals.…”

Section: Us-guided Hifu Treatmentmentioning

confidence: 99%

Improvement of fibroid-associated symptoms and quality of life after US-guided high-intensity focused ultrasound (HIFU) of uterine fibroids

Tonguc

Recker

Ganslmeier

et al. 2022

Sci Rep

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Uterine fibroids are the most common benign uterine tumors and can cause various severe symptoms as abnormal menstrual bleeding or pelvic pain. Therefore, the primary objective in the treatment of uterine fibroids is a sufficient symptom relief. Ultrasound (US)-guided High-intensity focused ultrasound (HIFU) is an effective non-invasive treatment strategy for ablation of uterine fibroids that can achieve a significant tumor volume reduction. The aim of the study is to evaluate if US-guided HIFU treatment can reduce fibroid-associated symptoms leading to an improvement of health-related quality of life. Fifty-five women with symptomatic uterine fibroids underwent US-guided HIFU ablation. Clinical evaluation was performed on the basis of the Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire (UFS-QOL) at baseline, 6 weeks, 3, 6, 9 and 12 months after HIFU. Imaging follow-up included contrast-enhanced ultrasound (CEUS) and contrast-enhanced MRI. A significant reduction of the Symptom Severity Scale (SSS) was observed between 6 weeks and 12 months after HIFU (49.9 ± 19.4 at baseline vs. 42.2 ± 20.1 at 6 weeks and 23.6 ± 12.7 at 12 months after treatment, p < 0.001) correlating with a significant improvement (p < 0.001) of Health-related Quality of Life (HRQL) (52.5 ± 22.7 at baseline vs. 59.8 ± 22 at 6 weeks and 77.9 ± 17.3 at 12 months after treatment). Significant postinterventional improvement was observed in every subscale of HRQL. In the majority of patients, only minor, short-lasting and self-limiting side effects were observed, e.g. soft tissue edema of the anterior lower abdominal wall in the acoustic pathway or transient moderate lower abdominal pain as during menstruation. One patient with a very large fibroid experienced strong short-lasting pain after the procedure; two patients experienced post-procedurally a transient sciatic nerve irritation. US-guided HIFU of uterine fibroids reduces disease-related symptoms and improves health-related quality of life.

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“…Soares et al (3) carried out a prospective study and expanded the exclusion criteria, which is one of the strengths of their article, with attention to factors that are known to affect uterine peristalsis, such as the use of hormonal contraceptives, the use of intrauterine devices, having amenorrhea (4) , and being in the menstrual phase. Excluding patients who presented with any of those factors increased the robustness of the findings.…”

mentioning

confidence: 99%