Impact of Vanadium Complexes with Tetradentate Schiff Base Ligands on the DPPC and EYL Liposome Membranes: EPR Studies

Abstract

This paper investigates the effect of three vanadium complexes with Schiff base-type tetradentate ligands of general formula N,N′-1,2-cyclohexylenebis(3,5-dichlorosalicylideneiminate) (V1); LVCl2 (L = N,N′-1,2-cyclohexylenebis(5-chlorosalicylideneiminate) (V2); and N,N′-1,3propylenebis (salicylideneiminate) (V3) on the fluidity of liposome membranes obtained by the sonication of natural lecithin (EYL) and synthetic lecithin (DPPC). The study was carried out with TEMPO and 16DOXYL spin probes using the EPR technique. The results show that the effect of the complexes on the fluidity of liposomes whose membranes are in the liquid crystalline phase is much stronger as compared to the liposome membranes in the gel phase.

Looking back, moving forward: protein corona of lipid nanoparticles

“…7,8 Moreover, conventional liposomes can be categorized by phospholipid type into cationic, anionic and neutral liposomes. 9,10 Among them, liposomes synthesized from neutral phospholipids such as phosphatidylcholine, 11 dipalmitoyl phosphatidylcholine (DPPC), 12,13 and 1,2-distearoyl- sn -glycero-3-phosphocholine (DSPC) 14,15 as lipid materials are neutral liposomes, while N -[1(2,3-dioloyloxy) propyl]- N , N , N -trimethylammonium chloride (DOTAP) 16 and oleic acid 17 are commonly used for the preparation of cationic and anionic liposomes, respectively. Ionic-rich liposome particles repel each other due to electrostatic interaction, reducing their aggregation ability, and thus enhancing physical stability.…”