The research objective is to analyze how the role of women in management in SMEs in the textile and clothing sector (TCS), in the southern region of the state of Guanajuato, manifests itself in the five dimensions of Entrepreneurial Orientation (EO). Methodologically this work is quantitative and explanatory, based on a model of structural equations estimated by using the information of a validated questionnaires applied to 103 women managers of the above-mentioned region, contributing to theoretically and empirically increament of the literature on the OE and promote it for a greater boost of business with female leaders who may contribute the socioeconomic development of the region. In conclusion, the women managers of the STC develop the five dimensions of the OE: innovation, by generating new models of garments and being at the forefront. Watering, by investing in raw materials or machinery. Proactivity because they are always looking for new ways to do the activities, they perform for the benefit of the business they lead and retain autonomy by making decisions that improve the performance of their business. Aggressive competitiveness by implementing new ways to conquer customers to excel compared to their competitors.