Particulate and surfactant systems are an integral part either in processing or product lines in essentially every major industry, including Energy and Minerals, Pharmaceutical, Agriculture & Food, Microelectronics, Healthcare, Cosmetics, Consumer Products, and Analytical Instrumentation & Services. In most applications, product and process specifications depend on the synergistic or competitive interactions between the particles and reagent schemes. The primary goal of our research efforts has been to generate the structure-property-performance correlations-based knowledge and technology platforms for industry to develop more sustainable products and processes. Engineering the physicochemical/mechanical properties of surfaces, particles, and self-assembling surfactant systems enables their enhanced performance in industrial applications. Specifically, understanding and control of the nano and atomicscale forces between particles and synthesis of functionalized particles form the foundation for targeted contributions in biomedical, advanced materials and minerals, sensor, and coating technologies. A synoptic overview of selected projects is presented in this review. Additional details can be found in the topic-specific references listed at the end of this manuscript.