Impacts of Penconazole and Its Enantiomers Exposure on Gut Microbiota and Metabolic Profiles in Mice

Meng, Zhiyuan; Liu, Li; Jia, Ming; Li, Ruisheng; Yan, Sen; Tian, Sinuo; Sun, Wei; Zhou, Zhiqiang; Zhu, Wentao

doi:10.1021/acs.jafc.9b02856

Cited by 38 publications

(20 citation statements)

References 51 publications

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“…A decrease in abundance and bacterial diversity was also shown after consumption of systemic triazole fungicide penconazole [26]. In mice treated with penconazole and its enantiomers, the relative content of the microbiota in the intestine, in particular, the cecum, changed.…”

Section: The Effect Of Pesticides On the Microbiome Of Model Organismsmentioning

confidence: 96%

The Effect of Pesticides on the Microbiome of Animals

et al. 2020

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In recent decades an increase in the use of pesticides to protect plants from pests, diseases and weeds has been observed. There are many studies on the effects of various pesticides on non-target organisms. This review aims to analyze and summarize published scientific data on the effects of pesticides on the animal microbiome. Pesticides can affect various parameters of the animal microbiome, such as the taxonomic composition of bacteria, bacterial biodiversity, and bacterial ratios and modify the microbiome of various organisms from insects to mammals. Pesticide induced changes in the microbiome reducing the animal’s immunity. The negative effects of pesticides could pose a global problem for pollinators. Another possible negative effect of pesticides is the impact of pesticides on the intestinal microbiota of bumblebees and bees that increase the body’s sensitivity to pathogenic microflora, which leads to the death of insects. In addition, pesticides can affect vitality, mating success and characteristics of offspring. The review considers methods for correcting of bee microbiome.

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Section: The Effect Of Pesticides On the Microbiome Of Model Organismsmentioning

confidence: 96%

The Effect of Pesticides on the Microbiome of Animals

et al. 2020

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“…The mice exposed to penconazole showed a reduced amount of Proteobacteria , while Bacteroidetes , Cyanobacteria and Actinobacteria significantly increased. Both enantiomers toxicity was assessed and revealed substantial alteration in the abundances of gut microbial communities [ 102 ]. The fungicide azoxystrobin has proved able to alter the GM in soil earthworms, ‘Enchytraeus crypticus’, specifically Proteobacteria , which significantly increased after the 2 and 5 mg/kg exposure [ 103 ].…”

Section: Fungicidesmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

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“…Chemical substances used in daily life and hygiene have enormous effects on the abundance of microbes. A mice study indicates that exposure to penconazole (a triazole fungicide) and its derivatives can significantly shift GM richness and associated metabolic profile by altering the growth of several bacteria including Lachnospiraceae, Erysipelotrichaceae, Rikenellaceae, Helicobacter and Bacteroidales (Meng et al 2019). Besides, it has been shown that low-concentration chemical exposure of diethyl phthalate, methyl paraben and triclosan can result in significant alteration of GM in adult mice, accompanied by the upregulation of Prevotella, downregulation of Bacilli and the subsequent reduction in body weight; however, no long-term effect has been observed in infants (Hu et al 2016a).…”

Section: Environmental Factorsmentioning

confidence: 99%

Impact of the factors shaping gut microbiota on obesity

et al. 2021

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Obesity is considered as a risk factor for chronic health diseases such as heart diseases, cancer and diabetes 2. Reduced physical activities, lifestyle, poor nutritional diet and genetics are among the risk factors associated with the development of obesity. In recent years, several studies have explored the link between the gut microbiome and the progression of diseases including obesity, with the shift in microbiome abundance and composition being the main focus. The alteration of gut microbiome composition affects both nutrients metabolism and specific gene expressions, thereby disturbing body physiology. Specifically, the abundance of fibre-metabolizing microbes is associated with weight loss and that of protein and fat-metabolizing bacteria with weight gain. Various internal and external factors such as genetics, maternal obesity, mode of delivery, breastfeeding, nutrition, antibiotic use and the chemical compounds present in the environment are known to interfere with the richness of the gut microbiota (GM), thus influencing weight gain/loss and ultimately the development of obesity. However, the effectiveness of each factor in potentiating the shift in microbes' abundance to result in significant changes that can lead to obesity is not yet clear. In this review, we will highlight the factors involved in shaping GM, their influence on obesity and possible interventions. Understanding the influence of these factors on the diversity of the GM and how to improve their effectiveness on disease conditions could be keys in the treatment of metabolic diseases.

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Impacts of Penconazole and Its Enantiomers Exposure on Gut Microbiota and Metabolic Profiles in Mice

Cited by 38 publications

References 51 publications

The Effect of Pesticides on the Microbiome of Animals

The Effect of Pesticides on the Microbiome of Animals

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Impact of the factors shaping gut microbiota on obesity

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