Impacts of single nucleotide polymorphisms in Fc gamma receptor IIA (
            <i>rs1801274</i>
            ) on lung transplant outcomes among Japanese lung transplant recipients

Kayawake, Hidenao; Chen‐Yoshikawa, Toyofumi F.; Tanaka, Satona; Tanaka, Yuka; Ohdan, Hideki; Yutaka, Yojiro; Yamada, Yoshito; Ohsumi, Akihiro; Nakajima, Daisuke; Hamaji, Masatsugu; Egawa, Hiroto; Date, Hiroshi

doi:10.1111/tri.13974

Cited by 5 publications

(5 citation statements)

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“…10 In this study, the median duration between LDLLT and the appearance of dnDSA in grafts donated from spousal donors was approximately 25 mo, which was longer than that of DDLT. This result may have been influenced by the shorter ischemic time, less frequency of PGD, and the smaller but “perfect” graft, which were observed in LDLLT, 2,10,18 when compared with that in DDLT.…”

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

“…The immunosuppressive agents orally administered were calcineurin inhibitors, such as cyclosporine or tacrolimus, mycophenolate mofetil, and prednisolone, as reported in some previous studies. 2,10,17 In our institution, transbronchial lung biopsy is not routinely performed. Therefore, acute cellular rejection (ACR) was diagnosed clinically based on the deterioration of the patient's respiratory condition and abnormal shadows in the lung field on chest radiography or CT. 17,18 Eligibility Criteria for LDLLT in Donors and Recipients Previous studies have reported the eligibility criteria for donors in LDLLT.…”

Section: Anti-hla Antibody Monitoring Administration Of Immunosuppres...mentioning

confidence: 99%

“…In Japan, where severe donor shortages have been a major issue, living-donor lobar lung transplantation (LDLLT) plays an important role in LTx. 2 Another issue is that the long-term outcomes of LTx are lower than those of other solid organ transplantations, including liver and kidney transplantations. 1,2 Moreover, the importance of the detection of de novo donor-specific antihuman leukocyte antigen (HLA) antibodies (dnD-SAs) has recently been recognized, and dnDSAs have been reported to influence poor prognosis after LTx.…”

Section: Introductionmentioning

confidence: 99%

“…2 Another issue is that the long-term outcomes of LTx are lower than those of other solid organ transplantations, including liver and kidney transplantations. 1,2 Moreover, the importance of the detection of de novo donor-specific antihuman leukocyte antigen (HLA) antibodies (dnD-SAs) has recently been recognized, and dnDSAs have been reported to influence poor prognosis after LTx. 3,4 It remains controversial whether HLA mismatches between donors and recipients (D/R HLA mismatches) influence postoperative outcomes of LTx including chronic lung allograft dysfunction (CLAD).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Spousal Donation on Postoperative Outcomes of Living-donor Lobar Lung Transplantation

et al. 2023

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Background. The effect of human leukocyte antigen mismatches between donors and recipients on postoperative outcomes of lung transplantation remains controversial. We retrospectively reviewed adult recipients receiving living-donor lobar lung transplantation (LDLLT) to examine the difference in de novo donor-specific antibody (dnDSA) development and clinically diagnosed unilateral chronic lung allograft dysfunction per graft (unilateral CLAD) between lung grafts donated by spouses (nonblood relatives) and nonspouses (relatives within the third degree). We also investigated the difference in prognoses between recipients undergoing LDLLTs including spouse donors (spousal LDLLTs) and not including spouse donors (nonspousal LDLLTs). Methods. In this study, 63 adult recipients undergoing LDLLTs (61 bilateral and 2 unilateral LDLLTs from 124 living donors) between 2008 and 2020 were enrolled. The cumulative incidence of dnDSAs per lung graft was calculated, and prognoses were compared between recipients undergoing spousal and nonspousal LDLLTs. Results. The cumulative incidence of both dnDSAs and unilateral CLAD in grafts donated by spouses was significantly higher than that in grafts donated by nonspouses (5-y incidence of dnDSAs: 18.7% versus 6.4%, P = 0.038; 5-y incidence of unilateral CLAD: 45.6% versus 19.4%, P = 0.011). However, there were no significant differences in the overall survival or chronic lung allograft dysfunction-free survival between recipients undergoing spousal and nonspousal LDLLTs (P > 0.99 and P = 0.434, respectively). Conclusions. Although there were no significant differences in prognoses between spousal and nonspousal LDLLTs, more attention should be paid to spousal LDLLTs because of the higher development rate of dnDSAs and unilateral CLAD.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Anti-hla Antibody Monitoring Administration Of Immunosuppres...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Spousal Donation on Postoperative Outcomes of Living-donor Lobar Lung Transplantation

et al. 2023

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Influence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation

Kayawake,

Sakanoue,

Tanaka

et al. 2024

Gen Thorac Cardiovasc Surg

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Objectives Generally, HLA matching between donors and recipients is not performed in lung transplantation (LTx). Therefore, whether HLA mismatch between donors and recipients (D/R mismatch) influences postoperative outcomes after LTx remains uncertain. In this study, we investigated the influence of D/R mismatch on postoperative outcomes after cadaveric LTx (CLT). Methods A total of 140 CLT procedures were performed between 2012 and 2020. After excluding 5 recipients with preformed DSA and 1 recipient undergoing re-LTx, 134 recipients were enrolled in this retrospective study. The postoperative outcomes were compared between recipients with higher and lower D/R mismatches. Results The median D/R mismatch (A/B/DR loci) was 4.0 (range, 1–6). When dividing these 134 recipients into two groups (H group [D/R mismatch ≥ 5, n = 57] and L group [D/R mismatch ≤ 4, n = 77]), there were no significant differences in the patient backgrounds. The lengths of hospital and intensive care unit stays were similar (p = 0.215 and p = 0.37, respectively). Although the overall survival was not significantly better in the H group than in the L group (p = 0.062), chronic lung allograft dysfunction-free survival was significantly better in the H group than in the L group (p = 0.027). Conversely, there was no significant difference in the cumulative incidence of de novo donor-specific anti-HLA antibodies (dnDSAs) between the two groups (p = 0.716). Conclusions No significant difference in dnDSA development was observed between patients with higher and lower D/R HLA mismatches. Given the favorable outcomes in the high HLA mismatch group, CLTs can be performed safely in recipients with high D/R HLA mismatches.

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Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array

Tomioka

Sugimoto

Yamamoto

et al. 2023

Sci Rep

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Renal dysfunction is a long-term complication associated with an increased mortality after lung transplantation (LT). We investigated the association of single-nucleotide polymorphisms (SNPs) with the development of renal dysfunction after LT using a Japanese-specific SNP array. First, eligible samples of 34 LT recipients were genotyped using the SNP array and divided into two groups, according to the presence of homozygous and heterozygous combinations of mutant alleles of the 162 renal-related SNPs. To identify candidate SNPs, the renal function tests were compared between the two groups for each SNP. Next, we investigated the association between the candidate SNPs and the time course of changes of the estimated glomerular filtration rate (eGFR) in the 99 recipients until 10 years after the LT. ΔeGFR was defined as the difference between the postoperative and preoperative eGFR values. Eight SNPs were identified as the candidate SNPs in the 34 recipients. Validation analysis of these 8 candidate SNPs in all the 99 recipients showed that three SNPs, namely, rs10277115, rs4690095, and rs792064, were associated with significant changes of the ΔeGFR. Pre-transplant identification of high-risk patients for the development of renal dysfunction after LT based on the presence of these SNPs might contribute to providing personalized medicine.

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Impacts of single nucleotide polymorphisms in Fc gamma receptor IIA ( rs1801274 ) on lung transplant outcomes among Japanese lung transplant recipients

Cited by 5 publications

References 44 publications

Impact of Spousal Donation on Postoperative Outcomes of Living-donor Lobar Lung Transplantation

Impact of Spousal Donation on Postoperative Outcomes of Living-donor Lobar Lung Transplantation

Influence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation

Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array

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