Impaired aortic elastic properties in patients with systemic sarcoidosis

Abstract

Presence and severity of Sar are associated with reduced aortic distensibility, irrespective of the disease duration, pulmonary artery pressure and lung function. In addition, patients with Sar have increased LVM and impaired myocardial performance.

Myocardial performance is impaired in patients with branch retinal vein occlusion

“…The Tei index is a prognostic index and an independent predictor of cardiac death due to various diseases. [12][13][14][15][16] In the present study, the Tei index and mitral A velocity were significantly higher, and E/A ratio significantly lower, in BRVO and hypertensive groups compared with healthy controls. Additionally, ejection time was lower in the BRVO group compared with healthy controls.…”

“…An increased Tei index is associated with an increased risk of cardiovascular events in some disorders such as systemic hypertension, metabolic syndrome, diabetes mellitus, chronic obstructive lung diseases and sarcoidosis. [12][13][14][15][16][22][23][24] It is possible that a similar relationship might occur in BRVO. General practitioners and ophthalmologists, both of whom are involved in the management of patients with BRVO, should be aware of the importance of BRVO as a marker of progressive cardiovascular disease and focus on prevention, identification and treatment of modifiable risk factors such as hypertension, hyperlipidemia and diabetes.…”

“…An increased Tei index has been shown to be a prognostic index and independent predictor of cardiac death in various heart diseases. [12][13][14][15][16] To the best of our knowledge, however, there have been no reports on the application of these methods in the assessment of patients with BRVO. The aim of the present study was to evaluate myocardial performance using the Tei index in patients with BRVO, and compare findings with evaluations in healthy controls and patients with hypertension.…”

Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets

“…In addition to the observed increase in the endothelial cell proportion, we observed a significant increase in POSTN+ and fibroblast-like endothelial cells as well as a significant decrease in cardiomyocyte-like endothelial cells relative to control. Fibrosis within blood vessel walls has been reported in CS patients, particularly in the aorta and coronary arteries (42,43). It could be postulated that there could be a link between this histopathological feature of CS and the expansion of fibroblast-like endothelial cells.…”

“…It could be postulated that there could be a link between this histopathological feature of CS and the expansion of fibroblast-like endothelial cells. While angiogenesis has not explicitly been investigated before in CS, dysfunction in cardiac microvasculature, aortic elastic properties and coronary flow reserve have been reported in CS patients (43)(44)(45). Moreover, upregulated angiogenesis has been reported in other forms of sarcoidosis, such as neurosarcoidosis and PS (46,47).…”