Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model

Shahriari, Yalda; Krusienski, Dean J.; Dadi, Yamini Sureka; Seo, Misun; Shin, Hee‐Sup; Choi, Jee Hyun

doi:10.3109/15622975.2015.1112036

Cited by 31 publications

(22 citation statements)

References 46 publications

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“…ASSRs are electrophysiological responses of neural circuits to periodic auditory stimuli and are commonly measured by EEG recordings. Alterations in ASSR phase locking and power in the gamma range (30–80Hz) have been observed in patients with multiple brain disorders 31,43 . To measure ASSRs, we applied five different randomly ordered frequencies with a pulse width of 1 millisecond (Fig 5).…”

Section: Resultsmentioning

confidence: 99%

“…P56 mice were used for auditory steady‐state response (ASSR) recording. The detailed procedures were described previously 31 . In brief, three microscrews were implanted on the skull above the right frontal lobe (2mm anteroposterior and 1mm medolateral to bregma) for the frontal EEG and above the left and right cerebellum for ground and reference electrodes in anesthetized mice (ketamine/xylazine cocktail (intraperitoneal injection), 120 and 6mg/kg, respectively).…”

Section: Methodsmentioning

confidence: 99%

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Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction

Lee

Zhang

Park

et al. 2020

Annals of Neurology

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Objective Genetic variants of the cytoplasmic FMR1‐interacting protein 2 (CYFIP2) encoding an actin‐regulatory protein are associated with brain disorders, including intellectual disability and epilepsy. However, specific in vivo neuronal defects and potential treatments for CYFIP2‐associated brain disorders remain largely unknown. Here, we characterized Cyfip2 heterozygous (Cyfip2+/−) mice to understand their neurobehavioral phenotypes and the underlying pathological mechanisms. Furthermore, we examined a potential treatment for such phenotypes of the Cyfip2+/− mice and specified a neuronal function mediating its efficacy. Methods We performed behavioral analyses of Cyfip2+/− mice. We combined molecular, ultrastructural, and in vitro and in vivo electrophysiological analyses of Cyfip2+/− prefrontal neurons. We also selectively reduced CYFIP2 in the prefrontal cortex (PFC) of mice with virus injections. Results Adult Cyfip2+/− mice exhibited lithium‐responsive abnormal behaviors. We found increased filamentous actin, enlarged dendritic spines, and enhanced excitatory synaptic transmission and excitability in the adult Cyfip2+/− PFC that was restricted to layer 5 (L5) neurons. Consistently, adult Cyfip2+/− mice showed increased seizure susceptibility and auditory steady‐state responses from the cortical electroencephalographic recordings. Among the identified prefrontal defects, lithium selectively normalized the hyperexcitability of Cyfip2+/− L5 neurons. RNA sequencing revealed reduced expression of potassium channel genes in the adult Cyfip2+/− PFC. Virus‐mediated reduction of CYFIP2 in the PFC was sufficient to induce L5 hyperexcitability and lithium‐responsive abnormal behavior. Interpretation These results suggest that L5‐specific prefrontal dysfunction, especially hyperexcitability, underlies both the pathophysiology and the lithium‐mediated amelioration of neurobehavioral phenotypes in adult Cyfip2+/− mice, which can be implicated in CYFIP2‐associated brain disorders. ANN NEUROL 2020;88:526–543

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction

Lee

Zhang

Park

et al. 2020

Annals of Neurology

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“…LSSRs have been widely used for studying auditory function in the healthy and diseased brain43444546474849, and they have been interpreted as an indication of the neural tissue being capable to temporally track sensory information flows45475051. Yet, at present, the neural generators that contribute to LSSRs remain poorly understood.…”

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Vocal sequences suppress spiking in the bat auditory cortex while evoking concomitant steady-state local field potentials

Hechavarría

Beetz

Macías

et al. 2016

Sci Rep

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The mechanisms by which the mammalian brain copes with information from natural vocalization streams remain poorly understood. This article shows that in highly vocal animals, such as the bat species Carollia perspicillata, the spike activity of auditory cortex neurons does not track the temporal information flow enclosed in fast time-varying vocalization streams emitted by conspecifics. For example, leading syllables of so-called distress sequences (produced by bats subjected to duress) suppress cortical spiking to lagging syllables. Local fields potentials (LFPs) recorded simultaneously to cortical spiking evoked by distress sequences carry multiplexed information, with response suppression occurring in low frequency LFPs (i.e. 2–15 Hz) and steady-state LFPs occurring at frequencies that match the rate of energy fluctuations in the incoming sound streams (i.e. >50 Hz). Such steady-state LFPs could reflect underlying synaptic activity that does not necessarily lead to cortical spiking in response to natural fast time-varying vocal sequences.

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“…In recent years, many new technologies have been developed for the dissection of neural circuits and most of them can be exclusively applied to mouse. For example, GBO studies of psychiatric disease models enable us to associate the functional roles of neuronal oscillations with the expression of behavioural symptoms 38 39 40 . Even though the functional relationship with high-order perceptual processing has been relatively well documented in the human brain, the document on the GBO representation for perceptual binding is lacking on mice.…”

Section: Discussionmentioning

confidence: 99%

Gamma-Band Activities in Mouse Frontal and Visual Cortex Induced by Coherent Dot Motion

Han

Hwang

Lee

et al. 2017

Sci Rep

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A key question within systems neuroscience is to understand how the brain encodes spatially and temporally distributed local features and binds these together into one perceptual representation. Previous works in animal and human have shown that changes in neural synchrony occur during the perceptual processing and these changes are distinguished by the emergence of gamma-band oscillations (GBO, 30–80 Hz, centered at 40 Hz). Here, we used the mouse electroencephalogram to investigate how different cortical areas play roles in perceptual processing by assessing their GBO patterns during the visual presentation of coherently/incoherently moving random-dot kinematogram and static dots display. Our results revealed that GBO in the visual cortex were strongly modulated by the moving dots regardless of the existence of a global dot coherence, whereas GBO in frontal cortex were modulated by coherence of the motion. Moreover, concurrent GBO across the multiple cortical area occur more frequently for coherently moving dots. Taken together, these findings of GBO in the mouse frontal and visual cortex are related to the perceptual binding of local features into a globally-coherent representation, suggesting the dynamic interplay across the local/distributed networks of GBO in the global processing of optic flow.

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Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model

Abstract: The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia".

Cited by 31 publications

References 46 publications

Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction

Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction

Vocal sequences suppress spiking in the bat auditory cortex while evoking concomitant steady-state local field potentials

Gamma-Band Activities in Mouse Frontal and Visual Cortex Induced by Coherent Dot Motion

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