Impaired endothelial function in female adolescents with type 1 diabetes measured by peripheral artery tonometry

Pareyn, Aagje; Allegaert, Karel; Asscherickx, Willeke; Peirsman, Eva; Verhamme, Peter; Casteels, Kristina

doi:10.1007/s00431-013-1988-5

Cited by 20 publications

(25 citation statements)

References 35 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, differences in baseline pulse amplitude in obese adolescents have not been previously reported. Our group, however, described similar findings in adolescents with type 1 diabetes, with significantly higher baseline pulse amplitude in the diabetes group vs. the control group (8). These findings were consistent with the data from the study of Hamburg et al in adults (7).…”

Section: Discussionsupporting

confidence: 92%

Impaired endothelial function in adolescents with overweight or obesity measured by peripheral artery tonometry

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

Impaired endothelial function in adolescents with overweight or obesity measured by peripheral artery tonometry

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…When comparing the values of measured AW characteristics in patients with diabetes mellitus type 1 with those of age-matched controls, it was found, as in other studies (12)(13)(14)(15) that patients with diabetes type 1 have impaired functional and structural AW characteristics. It seems that the changes of AW characteristics start to occur early in the disease course and slowly progress, finally leading to macrovascular complications.…”

Section: Control Group Treatment Groupsupporting

confidence: 66%

Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination

Savić

Janić

Lunder

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Improvement of arterial wall (AW) characteristics decreases cardiovascular risk. In a previous study, it was observed that AW characteristics in patients with diabetes mellitus type 1 are significantly improved by short-term treatment with a low-dose combination of fluvastatin and valsartan. Additionally, a unique phenomenon of prolonged effect after treatment discontinuation was suggested. The present study tested whether repeated treatm ent after a certain period results in the same beneficial effect, th ereby advancing the hypothesis that cyclic treatment can provide a long-term improvement of AW characteristics. A total of 44 patients with diabetes mellitus type 1 that participated in the previous study were recruited. Six months after the discontinuation of the initial treatment, the same treatment with a low-dose fluvastatin (10 mg daily) and valsartan (20 mg daily) combination (n=22) or placebo (n=22) was repeated. Brachial artery flow-mediated dilation (FMD), pulse wave velocity (PWV) and carotid artery β-stiffness were measured. It was found that the beneficial effect achieved with an initial 1-month treatment was completely regained following treatment repetition: FMD improved by 50.9% (P<0.01), PWV by 5.7% (P<0.001) and β-stiffness by 9.9% (P<0.001). In addition, a gradual decline of the obtained effects was observed, reaching the level of 9.6% for FM D, 6.3% for PWV and 9.5% for β-stiffness 6 months after treatm ent discontinuation. It was observed that repetition of treatment was similarly effective as the initial intervention. The benefits achieved by treatment steadily declined with time. Combining these findings, cyclic intermittent treatment with a low-dose fluvastatin and valsartan combination is proposed as a new cardiovascular preventive strategy in patients with DM1.

show abstract

“…Our study used the Endopat device to evaluate the endothelial function in T1DM, T2DM and NDM obese children and adolescents. Previous studies done in children and adolescents with diabetes are mainly in T1DM patients (7,10,(14)(15)(16)(17). Prospective studies with the EndoPAT on T1DM adolescents revealed the presence of endothelial dysfunction in 76.7% (7), and a negative correlation between endothelial function and A1C (10).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that children with T1DM had significant ED when compared with non-diabetics (16,17).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Microvascular Function in Children and Adolescents with Diabetes and Obesity

Kochummen

Umpaichitra

Marwa

et al. 2019

Int J Endocrinol Metab

View full text Add to dashboard Cite

Background: Endothelial dysfunction (ED) is a marker of vascular damage. Glycated hemoglobin (A1C) predicts vascular complications. The EndoPAT (peripheral arterial tonometry) device calculates the reactive hyperemic index (RHI), a measure of endothelial function. The greater the vasodilation, the higher the RHI. We hypothesized that children with poorly-controlled diabetes mellitus (DM) and non-diabetes mellitus (NDM) obese children have ED. Methods: A cross-sectional study using the EndoPAT device was performed on children with poorly-controlled DM and NDM children. ANOVA, t-test, Mann-Whitney U test, multiple linear regression and Spearman correlation were used. Results:Of 58 children that completed the study (aged 13.1 ± 3.42 years), 33 with type 1 diabetes (T1DM), 8 with type 2 diabetes (T2DM) and 17 were NDM obese children. Eighty-five percent were African-American, 60% were female and 79% entered puberty. The RHI of children with DM (1.42 ± 0.48) versus NDM obese group (1.40 ± 0.34) was not different (P = 0.86) regardless of the type of DM or body mass index. In the DM group, for every 1% increase in latest A1C, the RHI decreased by 0.097 (P = 0.01) after adjusting for age, gender, and type of DM. The RHI of DM patients with latest A1C of < 10% (1.70 ± 0.58) versus those with A1C ≥10% (1.21 ± 0.19) was statistically different (P = 0.02). In the total study population, males had significantly lower RHI (1.28 ± 0.36) when compared to females (1.51 ± 0.46), P = 0.04 but this difference disappeared when considering pubertal status and type of diabetes. Conclusions: Our data showed that patients with poorly-controlled DM as reflected by latest A1C of ≥ 10% had worse endothelial function as reflected by lower RHI score.

show abstract

Impaired endothelial function in female adolescents with type 1 diabetes measured by peripheral artery tonometry

Cited by 20 publications

References 35 publications

Impaired endothelial function in adolescents with overweight or obesity measured by peripheral artery tonometry

Impaired endothelial function in adolescents with overweight or obesity measured by peripheral artery tonometry

Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination

Assessment of Microvascular Function in Children and Adolescents with Diabetes and Obesity

Contact Info

Product

Resources

About